27 completed, 6 unknown, 4 terminated, 1 not yet recruiting. 40 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 40 | Completed 27, Unknown 6, Terminated 4, Not yet recruiting 1, Recruiting 1, Withdrawn 1 |
Follow Hypertrophy: new trials by email Literature Review of Hypertrophy trials Research Report on Hypertrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Angiotensin Receptor Blocker After TAVR in Severe Aortic Stenosis With Left Ventricular Hypertrophy (ARBITAR) Angiotensin Receptor Blocker (ARB) - Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy | Phase 4 | Not yet recruiting | Seoul National University Hospital | 632 | 2026-08-15 | 2026-07-29 |
| Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension Eplerenone, Chlorthalidone, Potassium - Hypertension, Left Ventricular Hypertrophy | Phase 4 | Recruiting | Brigham and Women's Hospital | 75 | 2023-08-25 | 2026-04-06 |
| Effect of Azilsartan on Atrial Fibrillation in Patients With Hypertension Azilsartan or antihypertensive drugs other than ACEI, ARB or ARNI - Hypertension, Atrial Fibrillation | Phase 4 | Unknown | Beijing Tsinghua Chang Gung Hospital | 400 | 2023-06-01 | 2023-05-03 |
| Sacubitril/Valsartan Versus Amlodipine in Hypertension and Left Ventricular Hypertrophy. sacubitril/valsartan, Amlodipine - Hypertension, Left Ventricular Hypertrophy | Phase 4 | Unknown | Shanghai Jiao Tong University School of Medicine | 120 | 2021-11-28 | 2023-04-12 |
| Empagliflozin and Cardiac Remodelling in People Without Diabetes Empagliflozin, Placebo - Cardiovascular Diseases, Left Ventricular Hypertrophy | Phase 4 | Completed | Unity Health Toronto | 169 | 2021-04-01 | 2023-02-17 |
| Study to Evaluate the Effect on Improvement of LVH by the Control of BP in Hypertension Patients With AV Disease Amlodipine 5mg, Losartan, Losartan and Amlodipine - Aortic Stenosis, Aortic Regurgitation | Phase 4 | Completed | Hanmi Pharmaceutical Company Limited | 128 | 2018-10-18 | 2022-09-15 |
| The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients sacubitril/valsatran, valsartan, placebo to valsartan - Heart Failure | Phase 4 | Completed | Novartis Pharmaceuticals | 55 | 2018-07-05 | 2024-01-05 |
| Effect of Etelcalcetide on Cardiac Hypertrophy in Hemodialysis Patients cardiac MRI, echocardiography with strain, Laboratory tests - Secondary Hyperparathyroidism, Chronic Kidney Disease Requiring Chronic Dialysis | Phase 4 | Completed | Rainer Oberbauer | 62 | 2017-10-01 | 2020-06-09 |
| Does Dapagliflozin Regress Left Ventricular Hypertrophy In Patients With Type 2 Diabetes? Dapagliflozin, Placebo - Type 2 Diabetes, Left Ventricular Hypertrophy | Phase 4 | Completed | University of Dundee | 66 | 2017-02-14 | 2019-07-09 |
| Antihypertensive Treatment in Masked Hypertension Allisartan Isoproxil, Placebo - Masked Hypertension | Phase 4 | Completed | Yan Li | 320 | 2017-02-14 | 2025-01-06 |
| Efficacy and Safety of Valsartan and Nebivolol/Valsartan in Hypertensive Patients With LVH Valsartan 80 mg - Hypertension Complicated, Hypertrophy, Left Ventricular | Phase 4 | Completed | Trinity Hypertension & Metabolic Research Institute | 30 | 2017-02-07 | 2018-04-11 |
| Study on the Effects of Sacubitril/Valsartan on Physical Activity and Sleep in Heart Failure With Reduced Ejection Fraction Patients. sacubitril/valsartan (LCZ696), enalapril, matching placebo sacubitril/valsartan (LCZ696) - Heart Failure, Reduced Ejection Fraction | Phase 4 | Completed | Novartis Pharmaceuticals | 140 | 2016-12-16 | 2021-10-07 |
| Everolimus and Tacrolimus Combination for Regression of Left Ventricular Hypertrophy in Renal Transplants Everolimus, Mycophenolate mofetil, Tacrolimus - Hypertrophy, Left Ventricular | Phase 4 | Completed | Edoardo Melilli | 20 | 2016-11-01 | 2021-01-08 |
| Effects of SGLT2 Inhibitor on Hemodynamic Parameters in Resistant Hypertensive Subjects Dapagliflozin 10mg, Glibenclamide 5Mg Tablet - Hypertension, Diabetes Mellitus, Type 2 | Phase 4 | Completed | University of Campinas, Brazil | 16 | 2016-07-01 | 2018-05-08 |
| Effects of Everolimus in Left Ventricular Hypertrophy After Conversion From Azathioprine: A Pilot Study Everolimus - Left Ventricular Hypertrophy | Phase 4 | Unknown | Instituto de Urologia e Nefrologia | 50 | 2015-07-01 | 2015-07-09 |
| MetfoRmin and Its Effects on Left Ventricular Hypertrophy in Normotensive Patients With Coronary Artery Disease Metformin XL, Placebo - Left Ventricular Hypertrophy, Insulin Resistance | Phase 4 | Completed | University of Dundee | 68 | 2015-03-01 | 2019-04-10 |
| Does Allopurinol Reduce Thickening of the Left Ventricle of the Heart in Patient With Treated Hypertension? Allopurinol, Placebo - Hypertension, Hypertrophy, Left Ventricular | Phase 4 | Completed | University of Dundee | 72 | 2014-09-01 | 2019-09-17 |
| Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy Eplerenone 50 mg Tab - Hypertension,Essential, Obstructive Sleep Apnea | Phase 4 | Completed | Poznan University of Medical Sciences | 125 | 2014-07-01 | 2017-06-14 |
| Does ALlopurinol Regress lefT Ventricular Hypertrophy in End Stage REnal Disease: The ALTERED Study Allopurinol, Placebo (for allopurinol) - End Stage Renal Disease, Left Ventricular Hypertrophy | Phase 4 | Completed | University of Dundee | 80 | 2013-09-01 | 2016-11-04 |
| Remote Ischemic Preconditioning Induces Myocardial RISK Signaling Pathway in Patients Undergoing Valvular Heart Surgery Remote ischemic preconditioning at left upper arm, Control group - Patients With Elective Aortic Valve Replacement | Phase 4 | Completed | Yonsei University | 79 | 2013-06-01 | 2016-11-22 |
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Hypertrophy, Left Ventricular (38) · Hypertension (12) · Aortic Valve Stenosis (6) · Kidney Failure, Chronic (6) · Heart Failure (5) · Cardiovascular Diseases (4) · Cardiomegaly (2) · Diabetes Mellitus, Type 2 (2) · Dilatation, Pathologic (2) · Hyperparathyroidism, Secondary (2) · Hypertension, Pulmonary (2) · Inflammation (2) · Acromegaly (1) · Acute Coronary Syndrome (1)
Heart Diseases (40) · Pathological Conditions, Anatomical (40) · Pathological Conditions, Signs and Symptoms (40) · Cardiomegaly (37) · Cardiovascular Diseases (36) · Vascular Diseases (18) · Pathologic Processes (9) · Female Urogenital Diseases (8) · Female Urogenital Diseases and Pregnancy Complications (8) · Male Urogenital Diseases (8) · Urogenital Diseases (8) · Urologic Diseases (8) · Chronic Disease (7) · Disease Attributes (7)
Eplerenone (4) · Valsartan (4) · Allopurinol (3) · Everolimus (3) · Amlodipine (2) · Control Groups (2) · Mycophenolic Acid (2) · Tablets (2) · Tacrolimus (2) · Tadalafil (2) · dapagliflozin (2) · sacubitril (2) · sacubitril and valsartan sodium hydrate drug combination (2) · Angiotensin Receptor Antagonists (1) · Chlorthalidone (1)
University of Dundee (4) · Ege University (3) · Novartis Pharmaceuticals (3) · Washington University School of Medicine (3) · A. D. Struthers (1) · AstraZeneca (1) · Beijing Tsinghua Chang Gung Hospital (1) · Brigham and Women's Hospital (1) · East Carolina University (1) · Edoardo Melilli (1) · Ercan OK (1) · Hanmi Pharmaceutical Company Limited (1) · Instituto de Urologia e Nefrologia (1) · Janssen Pharmaceutica N.V., Belgium (1) · Medical University of Vienna (1)
United States (8) · Turkey (Türkiye) (5) · United Kingdom (5) · China (4) · South Korea (4) · Austria (2) · Brazil (2) · Canada (2) · Denmark (2) · Spain (2) · Australia (1) · Finland (1) · Germany (1) · Japan (1) · New Zealand (1)
Ercan Ok, MD (3) · Allan D Struthers, BSc, MD, FRCP, FESC (1) · Allan D Struthers, BSc, MD, FRCP, FESC, FRSE (1) · Allan Struthers, MD, FRCP (1) · Andrzej Tykarski, Prof (1) · Brian R. Lindman, MD (1) · Brian R. Lindman, MD, MSCI (1) · Bruno Allolio, MD (1) · Chim Lang, MD (1) · Chim Lang, MD, FRCP (1) · Christopher Gingles, MBChB (1) · Duk-Hyun Kang (1) · Edoardo Melilli, MD (1) · Ender Hur, MD (1)
PMID 10450601, PMID 10678860, PMID 10908222, PMID 10940788, PMID 11208620, PMID 11422885, PMID 16376782, PMID 17494787, PMID 17921053, PMID 1798888, PMID 18404673, PMID 18458174, PMID 19687350, PMID 20016520, PMID 20411620, PMID 21388319, PMID 22172590, PMID 22306782, PMID 24107724, PMID 25545400, PMID 26208670, PMID 2698218, PMID 27648523, PMID 28151412, PMID 28835229, PMID 2936235, PMID 29424935, PMID 30723975, PMID 31268872, PMID 31299919, PMID 31651370, PMID 31672793, PMID 32578850, PMID 32905623, PMID 32978755, PMID 33825489, PMID 35559350, PMID 35872799, PMID 36335517, PMID 36398903, PMID 37729887, PMID 37932788, PMID 38006908, PMID 38997620, PMID 39091669
2014 (2), 2009 (1), 2016 (1), 2017 (1)