8 completed, 5 recruiting, 2 terminated, 2 unknown. 17 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Completed 8, Recruiting 5, Terminated 2, Unknown 2 |
| Phase 2 | 4 | Completed 2, Recruiting 1, Terminated 1 |
Follow Hypertrophy: new trials by email Literature Review of Hypertrophy trials Research Report on Hypertrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ATR 1072 in Participants With PRKAG2 Syndrome ATR 1072 - Cardiac Glycogenosis, Cardiomyopathy | Phase 1 / Phase 2 | Recruiting | Atrium Therapeutics | 37 | 2026-09-14 | 2026-09-18 |
| Therapeutic RSK1 Targeting in Myeloid Malignancies PMD-026 - Myeloid Malignancy | Phase 1 | Recruiting | Washington University School of Medicine | 30 | 2026-05-20 | 2026-10-21 |
| Fish Oil, Metformin and Heart Health in PCOS Fish oil, Metformin, Fish Oil and Metformin - PCOS, Cardiovascular Disease | Phase 1 | Recruiting | University of Alberta | 146 | 2025-11-01 | 2025-12-12 |
| A Trial of HS-10511 in Healthy Subjects HS-10511 Tablets, HS-10511 Tablets Placebo - Hypertrophic Cardiomyopathy | Phase 1 | Unknown | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 96 | 2024-01-31 | 2024-01-18 |
| A Study to Evaluate the Effects of Mavacamten in Healthy Participants Mavacamten - Healthy Participants | Phase 1 | Completed | Bristol-Myers Squibb | 84 | 2023-02-20 | 2023-10-12 |
| Phase IA and IB Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia AAVrh.10hFXN, serotype rh.10 adeno-associated virus (AAV) gene transfer vector expressing the cDNA coding for human FXN, Prednisone - Friedreich Ataxia, Cardiomyopathies | Phase 1 | Recruiting | Weill Medical College of Cornell University | 25 | 2022-02-22 | 2026-09-28 |
| MPN-RC 118 AVID200 in Myelofibrosis AVID200 - Primary Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis | Phase 1 | Completed | John Mascarenhas | 21 | 2019-02-15 | 2023-02-10 |
| Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia Laboratory Biomarker Analysis, Metformin Hydrochloride, Pharmacological Study - Anemia, Fatigue | Phase 1 | Completed | City of Hope Medical Center | 3 | 2017-09-07 | 2026-10-19 |
| Metabolic Imaging of the Heart Using Hyperpolarized (13C) Pyruvate Injection Hyperpolarized (13) Pyruvate Injection, Gadolinium - Hypertension, Hypertrophy | Phase 1 | Recruiting | Sunnybrook Health Sciences Centre | 112 | 2016-04-01 | 2026-01-29 |
| High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin LED-RL Phototherapy, Mock Therapy - Fibrosis, Scarring | Phase 1 | Completed | Jared Jagdeo, MD, MS | 60 | 2016-01-01 | 2017-03-31 |
| A Phase 1/2 Study of High-dose Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure MYDICAR Phase 1, MYDICAR Phase 2, Placebo Phase 2 only - Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy | Phase 1 / Phase 2 | Terminated | Celladon Corporation | 9 | 2015-04-01 | 2017-01-31 |
| Cardiac Allograft Remodeling and Effects of Sirolimus Cardiac MRI, Coronary angiography with IVUS, Cardiac Allograft Remodeling - Cardiac Hypertrophy, Immunosuppression | Phase 1 | Terminated | University of Nebraska | 42 | 2013-04-24 | 2023-08-30 |
| Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS) Valproic Acid, CT Scan, Blood Sample - ALPS, Hypersplenism | Phase 1 / Phase 2 | Completed | Koneti Rao | 6 | 2008-01-01 | 2013-03-21 |
| Resistance Training in Elderly protein drink, Resistance training - Sarcopenia, Atrophy | Phase 1 / Phase 2 | Completed | Maastricht University Medical Center | 26 | 2007-01-01 | 2015-09-23 |
| Biventricular Pacing in Hypertrophic Cardiomyopathy Biventricular Pacemaker - Hypertrophic Cardiomyopathy | Phase 1 | Unknown | University Hospital Birmingham | 30 | 2006-06-01 | 2007-07-20 |
| Pyrimethamine to Treat Autoimmune Lymphoproliferative Syndrome Pyrimethamine - Autoimmune Disease, Lymphatic Disease | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 8 | 2003-07-01 | 2008-03-04 |
| Pyrimethamine and Sulfadoxine for Treatment of Autoimmune Lymphoproliferative Syndrome Fansidar (pyrimethamine and sulfadoxine) - Autoimmune Disease, Lymphoproliferative Disorder | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 8 | 2001-03-01 | 2008-03-04 |
Splenomegaly (6) · Cardiomyopathies (5) · Cardiomegaly (4) · Cardiovascular Diseases (4) · Lymphadenopathy (4) · Autoimmune Lymphoproliferative Syndrome (3) · Cardiomyopathy, Hypertrophic (3) · Heart Diseases (3) · Anemia (2) · Autoimmune Diseases (2) · Fibrosis (2) · Lymphoproliferative Disorders (2) · Primary Myelofibrosis (2) · Ataxia (1)
Pathological Conditions, Anatomical (17) · Pathological Conditions, Signs and Symptoms (17) · Cardiovascular Diseases (6) · Hemic and Lymphatic Diseases (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Genetic Diseases, Inborn (5) · Heart Diseases (5) · Immune System Diseases (4) · Immunoproliferative Disorders (4) · Pathologic Processes (4) · Signs and Symptoms (4) · Aortic Stenosis, Subvalvular (3) · Aortic Valve Disease (3) · Aortic Valve Stenosis (3)
Metformin (2) · Pyrimethamine (2) · Blood Specimen Collection (1) · Cardiac Resynchronization Therapy Devices (1) · Exercise Test (1) · Fish Oils (1) · Gadolinium (1) · Injections (1) · MYK-461 (1) · Prednisone (1) · Pyruvic Acid (1) · Quality of Life (1) · Resistance Training (1) · Ritonavir (1) · Sirolimus (1)
National Institute of Allergy and Infectious Diseases (NIAID) (2) · Atrium Therapeutics (1) · Bristol-Myers Squibb (1) · Celladon Corporation (1) · City of Hope Medical Center (1) · Jared Jagdeo, MD, MS (1) · Jiangsu Hansoh Pharmaceutical Co., Ltd. (1) · John Mascarenhas (1) · Koneti Rao (1) · Maastricht University Medical Center (1) · Sunnybrook Health Sciences Centre (1) · University Hospital Birmingham (1) · University of Alberta (1) · University of Nebraska (1) · Washington University School of Medicine (1)
United States (12) · Canada (2) · Netherlands (1) · United Kingdom (1)
Amy W Zhou, M.D. (1) · Brian Lowes, MD (1) · Charles Cunningham, PhD (1) · Jared Jagdeo, MD, MS (1) · John Mascarenhas, MD (1) · Koneti Rao, MD (1) · Luc JC van Loon, PhD (1) · Michael P Frenneaux, MBBS(Hons) (1) · Nitya Nathwani, MD (1) · Ronald G Crystal, MD (1) · Ronald Hoffman, MD (1) · Ruben Mesa, MD (1)
PMID 10028970, PMID 10030657, PMID 10199738, PMID 10213344, PMID 10556226, PMID 10594802, PMID 10598732, PMID 10802712, PMID 10830164, PMID 10952828, PMID 11055975, PMID 11057898, PMID 11250334, PMID 11514367, PMID 11803349, PMID 12088775, PMID 12555153, PMID 12652219, PMID 12668503, PMID 12714020, PMID 12738602, PMID 12742978, PMID 12906982, PMID 12962864, PMID 1423934, PMID 14612424, PMID 14757690, PMID 14996650, PMID 15226426, PMID 15239621, PMID 15302787, PMID 15543153, PMID 15557389, PMID 16199143, PMID 16297769, PMID 16297770, PMID 16297806, PMID 16364861, PMID 16611334, PMID 16642009, PMID 16795076, PMID 17060862, PMID 17258148, PMID 1729347, PMID 17314109, PMID 17396135, PMID 17450150, PMID 17479097, PMID 17845572, PMID 18025531
P01CA108671 (1), R61HL151355 (1)