5 completed, 5 recruiting, 4 active not recruiting, 3 not yet recruiting. 20 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 20 | Completed 5, Recruiting 5, Active not recruiting 4, Not yet recruiting 3, Terminated 2, Unknown 1 |
Follow Hypergammaglobulinemia: new trials by email Literature Review of Hypergammaglobulinemia trials Research Report on Hypergammaglobulinemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers The Multimodal Lifestyle Intervention - Monoclonal Gammopathy of Uncertain Significance, Smoldering Myeloma | Not applicable | Not yet recruiting | Hackensack Meridian Health | 67 | 2026-10-01 | 2026-08-24 |
| Early Detection of Amyloidosis in Monoclonal Gammopathy Using Nuclear Medicine Imaging ¹⁸F-florbetaben - Monoclonal Gammopathy, Monoclonal Gammopathy of Undetermined Significance (MGUS) | Not applicable | Not yet recruiting | University of Zurich | 50 | 2026-10-01 | 2026-06-03 |
| FAST-M: Prolonged Overnight Fasting and Mediterranean Dietary Intervention for Patients With Multiple Myeloma or Its Precursor Disease Health Coaching, Prolonged Overnight Fasting (POF), Mediterranean Diet - Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance | Not applicable | Recruiting | University of Miami | 120 | 2026-04-07 | 2026-05-01 |
| Exploring the Effects of Korean-Style Mediterranean Diet (KORMED) and Physical Activity Measurement in Patients With MGUS/SMM: A Pilot Study KORMED Diet and Physical Activity Monitoring - Monoclonal Gammopathy of Undetermined Significance, Smoldering Myeloma | Not applicable | Not yet recruiting | Seoul National University Bundang Hospital | 20 | 2026-01-30 | 2026-01-21 |
| A Prospective Multicenter Study of the Effects of Plant-based Diets on Gut Microbiome and Derived Metabolites in Patients Affected by Smoldering Multiple Myeloma diet rich in fiber - Smoldering Multiple Myeloma (SMM) | Not applicable | Recruiting | Ciceri Fabio | 62 | 2025-10-31 | 2026-04-03 |
| A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM) or Monoclonal Gammopathy of Undetermined Significance (MGUS) Omega-3, Curcumin, Probiotic - Multiple Myeloma, Smoldering, Multiple Myeloma | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 200 | 2023-09-20 | 2026-10-05 |
| Early Detection of Multiple Myeloma to Fight Cancer Disparities: A Screening and Patient Navigation Program Multiple Myeloma M-Protein Analysis, Multiple Myeloma Knowledge Questionnaires - Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance | Not applicable | Active not recruiting | Case Comprehensive Cancer Center | 201 | 2023-06-16 | 2026-08-18 |
| PROFAST Intervention in Precursor Multiple Myeloma Prolonged Fasting Intervention, EDUCATION CONTROL - Cancer Prevention, Weight Loss | Not applicable | Completed | Dana-Farber Cancer Institute | 23 | 2023-03-06 | 2026-10-07 |
| A Study Comparing a Plant-Based Diet With Supplements and Placebo in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) Whole Foods Plant-based Diet, Algae Omega 3 + Curcumin, Placebo supplements - Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 180 | 2022-11-29 | 2026-04-16 |
| Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma Behavioral Intervention, Beta-Adrenergic Antagonist, Propranolol - Plasma Cell Myeloma, Recurrent Plasma Cell Myeloma | Not applicable | Recruiting | Roswell Park Cancer Institute | 175 | 2022-06-28 | 2025-12-01 |
| Geranylgeraniol Supplementation in Patients With Mevalonate Kinase Deficiency geranylgeraniol - Mevalonate Kinase Deficiency | Not applicable | Unknown | University Hospital, Motol | 6 | 2022-01-25 | 2024-07-12 |
| A Study of a Plant-Based Diet in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) Plant based meals - Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma | Not applicable | Active not recruiting | Memorial Sloan Kettering Cancer Center | 23 | 2021-06-03 | 2026-09-21 |
| Evaluation of the Impact of the Update SMM Criteria on the Natural History of SMM to Establish New Recommendations. Myelogram - Smoldering Multiple Myeloma | Not applicable | Active not recruiting | Intergroupe Francophone du Myelome | 395 | 2020-02-11 | 2024-03-06 |
| The Impact of Exercise on Stress, Fatigue, and Quality of Life in Individuals With Primary Immunodeficiency Disease Exercise Program - Primary Immune Deficiency Disorder, Common Variable Immunodeficiency | Not applicable | Completed | Stockton University | 36 | 2017-06-27 | 2018-09-06 |
| Dysregulation of Glutamine Activity in the Pathogenesis of Multiple Myeloma 5-Carbon C 13-labeled Glutamine, Biospecimen Collection, Uniformly-labeled [13C]glucose - Monoclonal Gammopathy of Undetermined Significance, Plasma Cell Myeloma | Not applicable | Completed | Mayo Clinic | 35 | 2017-06-02 | 2024-08-09 |
| Iceland Screens, Treats or Prevents Multiple Myeloma Clinical follow-up 1, Mental Health and Quality of Life questionnaire, Standard follow-up or treatment. - Monoclonal Gammopathy of Undetermined Significance | Not applicable | Active not recruiting | University of Iceland | 80761 | 2016-09-01 | 2025-09-30 |
| Genomic and Psychosocial Effects of the 3RP on Patients With MGUS and Smoldering Multiple Myeloma Relaxation Response Resiliency Program (3RP) - Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma | Not applicable | Completed | Dana-Farber Cancer Institute | 93 | 2013-10-01 | 2017-03-16 |
| Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer methadone hydrochloride, morphine sulfate, oxycodone hydrochloride - Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders | Not applicable | Terminated | M.D. Anderson Cancer Center | 1 | 2009-03-01 | 2020-09-24 |
| Music in Reducing Anxiety and Pain in Adult Patients Undergoing Bone Marrow Biopsy for Hematologic Cancers or Other Diseases music therapy - Chronic Myeloproliferative Disorders, Leukemia | Not applicable | Completed | Wake Forest University Health Sciences | 65 | 2006-06-01 | 2017-05-30 |
| Moxifloxacin Compared With Ciprofloxacin/Amoxicillin in Treating Fever and Neutropenia in Patients With Cancer amoxicillin-clavulanate potassium, ciprofloxacin, moxifloxacin hydrochloride - Chronic Myeloproliferative Disorders, Fever, Sweats, and Hot Flashes | Not applicable | Terminated | European Organisation for Research and Treatment of Cancer - EORTC | 351 | 2002-04-01 | 2012-09-24 |
Monoclonal Gammopathy of Undetermined Significance (14) · Smoldering Multiple Myeloma (12) · Multiple Myeloma (10) · Immunoglobulin Light-chain Amyloidosis (4) · Blast Crisis (3) · Burkitt Lymphoma (3) · Congenital Abnormalities (3) · Hodgkin Disease (3) · Immunoblastic Lymphadenopathy (3) · Leukemia (3) · Leukemia, Biphenotypic, Acute (3) · Leukemia, Hairy Cell (3) · Leukemia, Large Granular Lymphocytic (3) · Leukemia, Lymphocytic, Chronic, B-Cell (3) · Leukemia, Myeloid, Accelerated Phase (3)
Blood Protein Disorders (20) · Hematologic Diseases (20) · Hemic and Lymphatic Diseases (20) · Immune System Diseases (20) · Immunoproliferative Disorders (20) · Neoplasms (17) · Paraproteinemias (17) · Precancerous Conditions (12) · Cardiovascular Diseases (10) · Hemorrhagic Disorders (10) · Hemostatic Disorders (10) · Neoplasms by Histologic Type (10) · Vascular Diseases (10) · Lymphoproliferative Disorders (8)
Curcumin (2) · Resistance Training (2) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · Adrenergic beta-Antagonists (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Behavior Therapy (1) · Ciprofloxacin (1) · Diet, Mediterranean (1) · Diet, Plant-Based (1) · Dietary Fiber (1) · Docosahexaenoic Acids (1) · Glucose (1) · Mental Health (1) · Methadone (1) · Morphine (1)
Memorial Sloan Kettering Cancer Center (3) · Dana-Farber Cancer Institute (2) · Case Comprehensive Cancer Center (1) · Ciceri Fabio (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Hackensack Meridian Health (1) · Intergroupe Francophone du Myelome (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · Roswell Park Cancer Institute (1) · Seoul National University Bundang Hospital (1) · Stockton University (1) · University Hospital, Motol (1) · University of Iceland (1) · University of Miami (1)
United States (12) · Belgium (2) · France (2) · Italy (2) · Switzerland (2) · Czechia (1) · Germany (1) · Iceland (1) · Israel (1) · Monaco (1) · Slovakia (1) · South Korea (1) · Turkey (Türkiye) (1)
Urvi A Shah, MD, MS (3) · Carl O Landgren, MD (1) · Catherine Marinac, Ph.D (1) · David Siegel, MD (1) · Dominik C Benz, PD Dr. med. (1) · James D. Bearden, MD (1) · Jason Valent, MD (1) · Jens Hillengass (1) · John Denninger, MD/PhD (1) · Kerri Sowers, PT, DPT, NCS (1) · Michael J. Fisch, MD, MPH, FACP (1) · Pr. Olivier Decaux (1) · Sigurdur Y Kristinsson, Professor (1) · Suzanne C. Danhauer, PhD (1)
PMID 23358983, PMID 33308307, PMID 36747117, PMID 37439374, PMID 38466984, PMID 38560901, PMID 40681960, PMID 42447419
2016 (1), K23CA218742 (1), R21CA256644 (1)