217 completed, 50 terminated, 14 unknown, 14 withdrawn. 155 Phase 2, 99 Phase 1, 38 Not applicable, 32 Phase 3, 1 Early Phase 1.
Follow this condition Literature Review of Leukemia, Myeloid, Accelerated Phase trials Research Report on Leukemia, Myeloid, Accelerated Phase
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant Biospecimen Collection, Electronic Health Record Review, Haploidentical Hematopoietic Cell Transplantation - Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia | Phase 1 | Recruiting | City of Hope Medical Center | 46 | 2026-05-08 | 2026-07-28 |
| Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen (HLA)-Matched and Partially-HLA Mismatched Allogeneic Transplantation Patients With High-Risk Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), and Myelodysplastic Syndrome (MDS) Intensity modulated total marrow irradiation, Cyclophosphamide (CTX), Fludarabine (Fludara) - Acute Myeloid Leukemia, Relapsed, Adult, Acute Myeloid Leukemia Refractory | Phase 2 | Recruiting | University of Illinois at Chicago | 38 | 2025-02-04 | 2026-06-26 |
| Study of HS-10382 Combination in Patients With Chronic Myeloid Leukemia (CML) HS-10382+Flumatinib - Chronic Myelogenous Leukemia, CML Chronic Phase | Phase 1 | Not yet recruiting | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 100 | 2024-07-31 | 2024-07-31 |
| TGRX-678 Chinese Phase II in Chronic Myelogenous Leukemia (CML) Patients TGRX-678 - Chronic Myeloid Leukemia, Accelerated Phase CML | Phase 2 | Recruiting | Shenzhen TargetRx Co., Ltd. | 40 | 2024-07-15 | 2025-02-21 |
| MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing Magnetic-Activated Cell Sorter (CliniMACS, Miltenyi) - Leukemia, Acute Myeloid Leukemia in Remission | Not applicable | Recruiting | Medical College of Wisconsin | 40 | 2023-05-01 | 2026-05-13 |
| Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT) Orca-Q - Acute Myeloid Leukemia, Acute Lymphoid Leukemia | Phase 1 / Phase 2 | Recruiting | University of Florida | 40 | 2022-08-16 | 2026-09-01 |
| A Study of HS-10382 in Patients With Chronic Myeloid Leukemia. HS-10382(Part 1: Dose escalation), HS-10382(Part 2: Dose expansion) - CML, Chronic Phase, CML, Accelerated Phase | Phase 1 | Unknown | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 108 | 2022-04-28 | 2023-01-13 |
| Decitabine and HQP1351-based Chemotherapy Regimen for the Treatment Advanced CML based decitabine and olverembatinib（HQP1351)chemotherapy - Chronic Myeloid Leukemia in Myeloid Blast Crisis, Chronic Myeloid Leukaemia Transformation | Phase 2 | Unknown | Nanfang Hospital, Southern Medical University | 40 | 2021-12-01 | 2022-12-08 |
| SARS-CoV-2 Donor-Recipient Immunity Transfer Biospecimen Collection, Diagnostic Laboratory Biomarker Analysis, Electronic Health Record Review - Accelerated Phase CML, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia | Completed | City of Hope Medical Center | 26 | 2020-09-23 | 2024-04-08 | |
| Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia Bosutinib - Philadelphia Chromosome Positive CML, Accelerated Phase Chronic Myelogenous Leukemia | Phase 1 / Phase 2 | Active not recruiting | Children's Oncology Group | 60 | 2020-07-06 | 2026-10-01 |
| Decitabine, Venetoclax, and Ponatinib for the Treatment of Philadelphia Chromosome-Positive Acute Myeloid Leukemia or Myeloid Blast Phase or Accelerated Phase Chronic Myelogenous Leukemia Decitabine, Ponatinib, Venetoclax - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Myeloid Leukemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 20 | 2020-05-17 | 2026-06-05 |
| Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial Abemaciclib, Abiraterone, Afatinib - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Terminated | OHSU Knight Cancer Institute | 2 | 2020-04-01 | 2024-03-04 |
| Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation Vorinostat, Blood and Marrow Transplant (BMT), Tacrolimus (or cyclosporine) - Hematologic Diseases, Acute Leukemia in Remission | Phase 1 / Phase 2 | Active not recruiting | University of Michigan Rogel Cancer Center | 43 | 2020-02-04 | 2026-01-27 |
| Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors Ponatinib - Acute Myeloid Leukemia, Accelerated Phase Chronic Myeloid Leukemia | Phase 1 / Phase 2 | Recruiting | Incyte Biosciences International Sàrl | 70 | 2020-01-29 | 2026-10-09 |
| Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation Letermovir, Multi-peptide CMV-Modified Vaccinia Ankara Vaccine, Placebo Administration - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia | Phase 2 | Active not recruiting | City of Hope Medical Center | 7 | 2019-11-27 | 2025-11-14 |
| A Pivotal Study of HQP1351 in Patients of Chronic Myeloid Leukemia in Accelerated Phase With T315I Mutation HQP1351 - Chronic Myeloid Leukemia - Accelerated Phase | Phase 2 | Unknown | Ascentage Pharma Group Inc. | 23 | 2019-04-08 | 2023-04-03 |
| Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Reducing CMV Related Complications in Patients With Blood Cancer Undergoing Donor Stem Cell Transplant Multi-antigen CMV-Modified Vaccinia Ankara Vaccine, Laboratory Biomarker Analysis, Placebo - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission | Phase 2 | Withdrawn | City of Hope Medical Center | 2018-12-01 | 2018-11-21 | |
| CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant Multi-peptide CMV-Modified Vaccinia Ankara Vaccine - Accelerated Phase CML, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission | Phase 1 | Active not recruiting | City of Hope Medical Center | 34 | 2018-08-20 | 2026-09-28 |
| Evaluation of ETC-1907206 With Dasatinib in Advanced Haematologic Malignancies ETC-1907206, dasatinib - Ph+ Acute Lymphoblastic Leukemia (Ph+ALL), Ph- Acute Lymphoblastic Leukemia (Ph-ALL) | Phase 1 | Withdrawn | EDDC (Experimental Drug Development Centre), A*STAR Research Entities | 2018-04-25 | 2018-10-25 | |
| Low-Intensity Chemotherapy, Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia Blinatumomab, Cyclophosphamide, Cytarabine - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 22 | 2018-02-08 | 2026-08-19 |
Showing 20 of 318. Sign in to see all of them.
Leukemia, Myeloid, Chronic-Phase (260) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (257) · Blast Crisis (244) · Leukemia, Myeloid, Acute (232) · Leukemia, Lymphocytic, Chronic, B-Cell (210) · Leukemia (202) · Lymphoma, Non-Hodgkin (193) · Burkitt Lymphoma (192) · Lymphoma, Follicular (189) · Lymphoma, Large B-Cell, Diffuse (189) · Lymphoma, Mantle-Cell (188) · Hodgkin Disease (181) · Lymphoma, B-Cell, Marginal Zone (181) · Lymphoma, Large-Cell, Immunoblastic (177)
Bone Marrow Diseases (318) · Chronic Disease (318) · Disease Attributes (318) · Hemic and Lymphatic Diseases (318) · Neoplasms by Histologic Type (318) · Pathologic Processes (318) · Pathological Conditions, Signs and Symptoms (318) · Hematologic Diseases (317) · Leukemia, Myeloid (316) · Neoplasms (283) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (272) · Immune System Diseases (268) · Immunoproliferative Disorders (264) · Lymphatic Diseases (264) · Leukemia, Lymphoid (262)
Cyclophosphamide (80) · Peripheral Blood Stem Cell Transplantation (74) · fludarabine phosphate (73) · Busulfan (53) · Tacrolimus (50) · Cyclosporine (48) · Antilymphocyte Serum (45) · Methotrexate (45) · Mycophenolic Acid (43) · Filgrastim (39) · Radiotherapy (36) · Whole-Body Irradiation (35) · Methylprednisolone (28) · Melphalan (25) · Cord Blood Stem Cell Transplantation (24)
Fred Hutchinson Cancer Center (47) · National Cancer Institute (NCI) (20) · City of Hope Medical Center (19) · M.D. Anderson Cancer Center (19) · Memorial Sloan Kettering Cancer Center (16) · Roswell Park Cancer Institute (13) · Case Comprehensive Cancer Center (12) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (9) · Masonic Cancer Center, University of Minnesota (8) · Barbara Ann Karmanos Cancer Institute (7) · OHSU Knight Cancer Institute (7) · Asan Medical Center (6) · Jonsson Comprehensive Cancer Center (6) · Vanderbilt-Ingram Cancer Center (6) · European Organisation for Research and Treatment of Cancer - EORTC (5)
United States (280) · France (11) · Germany (11) · Italy (11) · Canada (10) · South Korea (9) · Belgium (8) · Switzerland (7) · United Kingdom (7) · Israel (5) · Netherlands (5) · Australia (4) · China (4) · Slovakia (4) · Spain (4)
Philip L. McCarthy, MD (6) · Kyoo H. Lee, MD (5) · Ryotaro Nakamura, MD (5) · Judith E. Karp, MD (4) · Ryotaro Nakamura (4) · Ann E. Woolfrey, MD (3) · Brenda Sandmaier (3) · Claudio Anasetti, MD (3) · David G. Savage, MD (3) · Elias Jabbour (3) · John E. Wagner, MD (3) · Jorge Cortes, MD (3) · Mary C. Territo, MD (3) · Paul Martin (3) · Roger Strair, MD, PhD (3)
PMID 32499241, PMID 21715313, PMID 35007144, PMID 10204198, PMID 15107815, PMID 15459300, PMID 15466923, PMID 15570084, PMID 16775234, PMID 16960978, PMID 17397698, PMID 17562873, PMID 17640728, PMID 17910637, PMID 18327587, PMID 18698002, PMID 18769450, PMID 18989154, PMID 19139736, PMID 19179301, PMID 19270260, PMID 19286996, PMID 19369231, PMID 19841031, PMID 1994541, PMID 20124511, PMID 20131302, PMID 20858843, PMID 21403127, PMID 21523798, PMID 21719601, PMID 21791475, PMID 22002488, PMID 22157574, PMID 22259028, PMID 22430088, PMID 22480131, PMID 23092873, PMID 23358983, PMID 23443507, PMID 24362550, PMID 24474568, PMID 24530972, PMID 25085357, PMID 26175532, PMID 26210442, PMID 26432046, PMID 26700120, PMID 26700123, PMID 26764356
P30CA015704 (11), P30CA033572 (11), P30CA006973 (10), P30CA043703 (9), P01CA018029 (8), P30CA068485 (7), P30CA016672 (6), P30CA022453 (6), P30CA072720 (5), P01CA015396 (4), P30CA016086 (4), P30CA036727 (3), U01CA070095 (3), 2023 (2), N01CM62202 (2)