121 completed, 47 recruiting, 26 active not recruiting, 20 terminated. 108 Phase 2, 96 Phase 1, 31 Phase 3, 20 Not applicable, 3 Early Phase 1.
Follow Leukemia, Biphenotypic, Acute: new trials by email Literature Review of Leukemia, Biphenotypic, Acute trials Research Report on Leukemia, Biphenotypic, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome Allogeneic CD34+-enriched and CD45RA-depleted PBSCs, Biospecimen Collection, Bone Marrow Aspiration - Acute Biphenotypic Leukemia, Acute Leukemia | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 52 | 2027-01-01 | 2026-09-14 |
| Study to Characterize Mismatched to Fully HLA-Matched Ossium HPC, Marrow and Living Donor Transplantation in Patients With Hematologic Malignancies Ossium HPC, Marrow, Standard of care living donor - Haplo Related, Standard of care living donor - Mismatched Unrelated - Hematologic Malignancy, Acute Leukemia | Not applicable | Not yet recruiting | Ossium Health, Inc. | 300 | 2026-12-01 | 2026-09-10 |
| Prophylactic DLI-X for Leukemia Relapse After HCT Exercise Mobilized Prophylactic DLI, Standard Prophylactic DLI - Acute Lymphoid Leukemia, Acute Myeloid Leukemia | Phase 1 | Not yet recruiting | University of Arizona | 180 | 2026-11-30 | 2026-10-22 |
| Real World Asparaginase Therapy Toxicity Drug Toxicity | Not yet recruiting | St. Jude Children's Research Hospital | 200 | 2026-11-01 | 2026-10-22 | |
| Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More Treatment Biospecimen Collection, Blinatumomab, Bone Marrow Aspiration - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Not yet recruiting | SWOG Cancer Research Network | 90 | 2026-10-14 | 2026-10-13 |
| Randomization for the Identification of Best Treatment Intensity for Less Fit Adults With Acute Myeloid Leukemia and Myeloid Neoplasms Biospecimen Collection, Bone Marrow Collection, Electronic Health Record Review - Acute Leukemia of Ambiguous Lineage, Acute Myeloid Leukemia | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 50 | 2026-10-13 | 2026-10-19 |
| A Study to Find the Highest Dose of SNDX-5613 (Revumenib) as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, and Mixed Phenotype Acute Leukemia Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 | Withdrawn | Children's Oncology Group | 2026-09-10 | 2026-05-05 | |
| HVA in the Treatment of Mixed-Phenotype Acute Leukemia(MPAL). HVA - Newly Diagnosed Mixed Phenotype Acute Leukemia (MPAL) | Phase 2 | Enrolling by invitation | Guangdong Second Provincial General Hospital | 40 | 2026-04-01 | 2026-04-08 |
| A Study of Revumenib and Mezigdomide in People With Leukemia Revumenib, Mezigdomide - Leukemia, Acute Leukemia | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 52 | 2026-01-16 | 2026-10-20 |
| Subcutaneous Blinatumomab for Treatment of Adult Patients With CD19-Positive Mixed Phenotype Acute Leukemia (MPAL) Subcutaneous Blinatumomab - CD19 Positive, Mixed Phenotype Acute Leukemia (MPAL) | Phase 2 | Recruiting | West Virginia University | 78 | 2026-01-15 | 2026-04-13 |
| A Study of JNJ-75276617 in Combination With Conventional Chemotherapy for Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias JNJ-75276617, Fludarabine, Cytarabine - Acute Leukemias, Acute Myeloid Leukemia | Phase 1 | Withdrawn | Janssen Research & Development, LLC | 2025-12-26 | 2025-06-22 | |
| Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Orca-T - Leukemia, Myeloid, Acute, Myelodysplastic Syndromes | Phase 2 | Recruiting | Orca Biosystems, Inc. | 80 | 2025-12-09 | 2026-07-07 |
| Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT ORCA-T - Acute Myeloid Leukemia, Acute Lymphoid Leukemia | Phase 1 | Recruiting | Stanford University | 24 | 2025-12-01 | 2026-06-23 |
| Combination Chemotherapy (FLAG-Ida) Followed Immediately by Reduced-Intensity Total Body Radiation Therapy and Donor Hematopoietic Cell Transplant for the Treatment of Adults Age 60 and Older With Newly Diagnosed Adverse-Risk Acute Myeloid Leukemia or Other High-Grade Myeloid Cancer Allogeneic Hematopoietic Stem Cell Transplantation, Biospecimen Collection, Bone Marrow Aspiration - Acute Leukemia of Ambiguous Lineage, Acute Myeloid Leukemia | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 20 | 2025-09-26 | 2026-07-20 |
| Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse Decitabine, Bone Marrow Aspiration, Bone Marrow Biopsy - Acute Myeloid Leukemia, Acute Undifferentiated Leukemia | Phase 1 / Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 36 | 2025-09-23 | 2026-05-15 |
| Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia Asparaginase Erwinia chrysanthemi, Biospecimen Collection, Blinatumomab - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | National Cancer Institute (NCI) | 153 | 2025-06-05 | 2026-10-21 |
| Leukemia Stem Cell-based Assay to Predict Relapse and Survival in Patients With Acute Myeloid Leukemia Detection of leukemia stem cell using multiparameter flow cytometry - Acute Myeloid Leukemia (AML), MLL Rearrangement | Recruiting | Peking University People's Hospital | 210 | 2025-06-01 | 2026-04-17 | |
| Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19) Dose Level 1, VNX-101, Dose Level 2, VNX-101, Dose Level 3, VNX-101 - B-cell Acute Lymphoblastic Leukemia, Large B-cell Lymphoma | Phase 1 / Phase 2 | Recruiting | Vironexis Biotherapeutics Inc. | 32 | 2025-05-30 | 2026-08-06 |
| Feasibility and Safety of Donor-derived NK-cell Infusions for Leukemia Relapse Prophylaxis After Hematopoietic Stem Cell Transplantation Donor-derived Natural Killer Cell - Acute Myeloid Leukemia, Acute Lymphoblastic T-cell Leukemia | Phase 2 | Recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 15 | 2025-05-09 | 2025-12-01 |
| Venetoclax + Azacytidine for Newly Diagnosed ETP-like ALL and T-ALL With Myeloid Mutations Venetoclax, Azacitidine, Cytarabine - Early T Acute Lymphoblastic Leukemia, T-Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | yuejun Liu | 32 | 2025-04-01 | 2025-06-10 |
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Precursor Cell Lymphoblastic Leukemia-Lymphoma (182) · Leukemia, Myeloid, Acute (176) · Myelodysplastic Syndromes (108) · Leukemia (97) · Leukemia, Lymphocytic, Chronic, B-Cell (94) · Burkitt Lymphoma (93) · Leukemia, Myelomonocytic, Chronic (89) · Lymphoma, Non-Hodgkin (82) · Hodgkin Disease (78) · Lymphoma, Follicular (76) · Myeloproliferative Disorders (76) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (76) · Leukemia, Myeloid, Accelerated Phase (75) · Lymphoma, Mantle-Cell (74)
Hemic and Lymphatic Diseases (245) · Lymphatic Diseases (243) · Immunoproliferative Disorders (242) · Neoplasms by Histologic Type (242) · Immune System Diseases (241) · Leukemia, Lymphoid (241) · Hematologic Diseases (238) · Neoplasms (225) · Lymphoproliferative Disorders (223) · Leukemia, Myeloid (195) · Bone Marrow Diseases (156) · Pathological Conditions, Signs and Symptoms (151) · Leukemia (148) · Pathologic Processes (148) · Disease Attributes (145)
Cyclophosphamide (58) · Cytarabine (44) · fludarabine phosphate (37) · Methotrexate (36) · Whole-Body Irradiation (33) · Mycophenolic Acid (29) · Filgrastim (27) · fludarabine (26) · Peripheral Blood Stem Cell Transplantation (22) · Vincristine (22) · Cyclosporine (20) · Busulfan (19) · Dexamethasone (19) · Specimen Handling (19) · Methylprednisolone (17)
Fred Hutchinson Cancer Center (32) · M.D. Anderson Cancer Center (22) · National Cancer Institute (NCI) (18) · Children's Oncology Group (14) · Memorial Sloan Kettering Cancer Center (10) · St. Jude Children's Research Hospital (7) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (6) · City of Hope Medical Center (5) · European Organisation for Research and Treatment of Cancer - EORTC (5) · Asan Medical Center (4) · Case Comprehensive Cancer Center (4) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (4) · Northwestern University (4) · Orca Biosystems, Inc. (4) · St. Petersburg State Pavlov Medical University (4)
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Filippo Milano (4) · Kyoo H. Lee, MD (3) · Marie Bleakley (3) · Roland Walter (3) · Ann Dahlberg (2) · Anna Halpern (2) · Claudio Anasetti, MD (2) · David Maloney (2) · Elisabeth Paietta, PhD (2) · Elizabeth Krakow (2) · Farid Boulad, MD (2) · Ivana Gojo (2) · Jacob Appelbaum, MD, PhD (2) · Jorge Cortes, MD (2) · Naval Daver (2)
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P30CA015704 (19), U10CA180886 (9), P30CA006973 (6), P01CA018029 (5), P30CA016672 (4), P01CA078902 (3), P30CA072720 (3), U01CA062505 (3), U01CA097452 (3), P30CA015083 (2), P30CA016086 (2), P30CA033572 (2), P30CA043703 (2), P30CA068485 (2), P50HL110787 (2)