Paraproteinemias: Clinical Trials

4,280 trials for Paraproteinemias, newest first

ClinicalTrials Daily  ·  Areas  ·  Conditions  ·  Drugs  ·  Sponsors  ·  

1970 completed, 598 recruiting, 566 terminated, 390 unknown. 1882 Phase 2, 1389 Phase 1, 418 Phase 3, 375 Not applicable, 101 Early Phase 1.

By phase and status

PhaseTrialsStatus
Phase 21882Completed 900, Terminated 291, Recruiting 206, Active not recruiting 175, Unknown 148, Withdrawn 100, Not yet recruiting 53, Suspended 6, Enrolling by invitation 3
Phase 11389Completed 654, Terminated 246, Recruiting 171, Unknown 123, Active not recruiting 93, Withdrawn 51, Not yet recruiting 43, Suspended 7, Enrolling by invitation 1
Phase 3418Completed 212, Active not recruiting 54, Recruiting 52, Unknown 42, Terminated 32, Not yet recruiting 19, Withdrawn 6, Suspended 1
Not applicable375Completed 152, Recruiting 82, Terminated 45, Unknown 37, Not yet recruiting 26, Active not recruiting 18, Withdrawn 11, Suspended 3, Enrolling by invitation 1
Early Phase 1101Recruiting 29, Unknown 25, Not yet recruiting 14, Completed 13, Active not recruiting 6, Terminated 6, Withdrawn 6, Suspended 2
Phase 462Completed 26, Recruiting 11, Unknown 9, Not yet recruiting 6, Active not recruiting 4, Withdrawn 4, Terminated 2

Follow Paraproteinemias: new trials by email Literature Review of Paraproteinemias trials Research Report on Paraproteinemias

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

TrialPhaseStatusSponsorEnrollmentStartUpdated
MM-CARE: Cardiovascular Risk Assessment in Adults With Multiple Myeloma
Oncology-Embedded Cardiovascular Risk Assessment Pathway, Primary Care Provider-Directed Cardiovascular Risk Assessment Pathway - Multiple Myeloma, Heart Disease Risk Factors
Not applicableNot yet recruitingUniversity of Vermont Medical Center332028-02-012026-08-25
Study of YKST02 in Adults With Relapsed or Refractory Multiple Myeloma
YKST02 - Relapsed or Refractory Multiple Myeloma (RRMM)
Phase 2Not yet recruitingExcyte Biopharma Ltd642027-12-012026-11-06
The Feasibility and Effects of Exercise on Patients Suffering From Multiple Myeloma
Individual Exercise, Group Exercise - Multiple Myeloma
Not applicableSuspendedMedical University of Vienna452027-09-012026-10-09
Engineered Dendritic Cell Vaccines for Multiple Myeloma
DC vaccines - Multiple Myeloma or Plasmacytoma
Phase 1Not yet recruitingShenzhen Geno-Immune Medical Institute102027-06-302026-11-02
²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma
Allogeneic Hematopoietic Stem Cell Transplantation, Astatine At 211 Anti-CD38 Monoclonal Antibody OKT10-B10, Cyclophosphamide - Multiple Myeloma, Recurrent Multiple Myeloma
Phase 1WithdrawnFred Hutchinson Cancer Center2027-06-012026-09-11
Testing the Investigational Medication Combination of Daratumumab and Teclistamab Compared to the Usual Treatment (Daratumumab, Pomalidomide, Dexamethasone or Daratumumab, Carfilzomib, Dexamethasone) for Patients With High-risk Multiple Myeloma Refractory or in First Relapse
Biospecimen Collection, Bone Marrow Biopsy, Carfilzomib - Recurrent Multiple Myeloma, Refractory Multiple Myeloma
Phase 2RecruitingNational Cancer Institute (NCI)802027-05-222026-11-04
Testing the Investigational Medication Combination of Teclistamab and Pomalidomide Compared to the Usual Treatment (Carfilzomib, Pomalidomide, and Dexamethasone) for Patients With Multiple Myeloma Who Have Relapsed Shortly After Treatment
Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Multiple Myeloma, Refractory Multiple Myeloma
Phase 1 / Phase 2RecruitingNational Cancer Institute (NCI)1622027-04-122026-10-16
Restrictive Versus Standard Antibiotic Treatment During CAR-T Therapy
ceftazidime, ciprofloxacin, Standard-of-Care Antibiotic Strategy - Large B-Cell Lymphoma (LBCL), Multiple Myeloma (MM)
Phase 2Not yet recruitingZealand University Hospital1502027-03-012026-09-25
MMulti-Immune HR; Multi-Target Immunotherapy for High-Risk Multiple Myeloma
teclistamab+daratumumab followed by talquetamab+daratumumab followed by duration treatment with daratumumab and lenalidomide extended/maintenance, melphalan (MEL)-based hematopietic stem cell transplantation (HSCT) followed by drug therapy - Multiple Myeloma (MM)
Phase 2Not yet recruitingUniversity of Arkansas502027-03-012026-09-02
BLOOD-dose: A Platform Trial Evaluating Dose Optimization in Hematological Diseases.
teclistamab OR talquetamab OR elranatamab OR linvoseltamab, BTK inhibitors (ibrutinib and zanubrutinib) - Waldenstrom Macroglobulinaemia, Multiple Myeloma
Phase 4Not yet recruitingAnne Louise Tølbøll Sørensen4002027-03-012026-03-16
Microbiome Intervention for CAR-T Optimization and Response (MICRO-CART)
Live Biotherapeutic Product (LBP), Placebo - Lymphoma, B-Cell, Multiple Myeloma
Phase 1Not yet recruitingUniversity of Chicago322027-02-232026-10-22
Teclistamab In Waldenstrom's Macroglobulinemia
Teclistamab - Waldenstrom's Macroglobulinemia
Phase 2Not yet recruitingMassachusetts General Hospital242027-02-192026-09-01
To Evaluate Safety and Efficacy of Anitocabtagene Autoleucel Versus Autologous Stem Cell Transplant in Newly Diagnosed Multiple Myeloma
Anitocabtagene Autoleucel, Isatuximab, Bortezomib - Newly Diagnosed Multiple Myeloma
Phase 3Not yet recruitingKite, A Gilead Company7502027-02-012026-10-29
Early Prophylactic rhTPO Administration for Thrombocytopenia Associated With EAP Regimen-Based Hematopoietic Stem Cell Mobilization
rhTPO prophylaxis plus EAP stem-cell mobilization - Multiple Myeloma (MM), Lymphoma, Large B-Cell, Diffuse (DLBCL), Lymphoma, Hematopoietic Stem Cell Mobilization
Phase 2 / Phase 3Not yet recruitingThe Affiliated People's Hospital of Ningbo University702027-01-012026-09-30
Isa-VRdlite for of Frail and/or Much Older Patients With High Risk Newly Diagnosed Multiple Myeloma Base on Circulating Plasma Cells
Isatuximab, VRD - Multiple Myeloma
Phase 2 / Phase 3Not yet recruitingThe Affiliated People's Hospital of Ningbo University152027-01-012026-10-02
A Trial to Evaluate Safety and Efficacy of Anitocabtagene Autoleucel Versus Standard of Care in Newly Diagnosed Multiple Myeloma
Anitocabtagene autoleucel, Daratumumab, Bortezomib - Newly Diagnosed Multiple Myeloma
Phase 3Not yet recruitingKite, A Gilead Company6002027-01-012026-10-21
Frontline Combination CAR-T Cell Therapy for Multiple Myeloma or Plasmacytoma
CAR-T cells - Multiple Myeloma, Plasmacytoma
Phase 1 / Phase 2Not yet recruitingShenzhen Geno-Immune Medical Institute202026-12-312026-11-02
Multi-CAR T Cell Therapy in the Treatment of Multiple Myeloma
CAR T cells - Multiple Myeloma
Phase 1 / Phase 2Not yet recruitingShenzhen Geno-Immune Medical Institute202026-12-312026-10-30
A Study in Participants With Relapsed or Refractory Multiple Myeloma for QLS4131
QLS4131, Pomalidomide Capsules, Bortezomib for Injection - Relapsed or Refractory Multiple Myeloma
Phase 3Not yet recruitingQilu Pharmaceutical Co., Ltd.3002026-12-302026-11-12
Comparing Bispecific Antibody Treatment to Autologous Stem Cell Transplant for Newly Diagnosed, Standard Risk Multiple Myeloma
Daratumumab and Recombinant Human Hyaluronidase, Lenalidomide, Bortezomib - Multiple Myeloma (MM)
Phase 2 / Phase 3Not yet recruitingAlliance for Clinical Trials in Oncology9202026-12-232026-10-22

Showing 20 of 4280. Sign in to see all of them.

Narrower conditions

Multiple Myeloma (3675)  ·  Lymphoma, Non-Hodgkin (609)  ·  Leukemia, Lymphocytic, Chronic, B-Cell (596)  ·  Lymphoma (581)  ·  Neoplasms, Plasma Cell (537)  ·  Waldenstrom Macroglobulinemia (521)  ·  Lymphoma, Follicular (486)  ·  Lymphoma, B-Cell, Marginal Zone (469)  ·  Lymphoma, Mantle-Cell (465)  ·  Precursor Cell Lymphoblastic Leukemia-Lymphoma (454)  ·  Hodgkin Disease (452)  ·  Recurrence (433)  ·  Lymphoma, Large B-Cell, Diffuse (426)  ·  Leukemia (368)  ·  Leukemia, Myeloid, Acute (366)

Broader conditions

Immune System Diseases (4267)  ·  Immunoproliferative Disorders (4265)  ·  Neoplasms by Histologic Type (4172)  ·  Hemic and Lymphatic Diseases (4147)  ·  Blood Protein Disorders (4121)  ·  Lymphoproliferative Disorders (4118)  ·  Hematologic Diseases (4088)  ·  Cardiovascular Diseases (4043)  ·  Vascular Diseases (4036)  ·  Hemorrhagic Disorders (4034)  ·  Hemostatic Disorders (4029)  ·  Neoplasms (4014)  ·  Neoplasms, Plasma Cell (3644)  ·  Lymphatic Diseases (1258)

Interventions

Dexamethasone (910)  ·  Bortezomib (508)  ·  Lenalidomide (483)  ·  Cyclophosphamide (393)  ·  Melphalan (274)  ·  Calcium Dobesilate (271)  ·  daratumumab (257)  ·  pomalidomide (225)  ·  carfilzomib (192)  ·  fludarabine phosphate (148)  ·  Peripheral Blood Stem Cell Transplantation (134)  ·  Thalidomide (130)  ·  Rituximab (128)  ·  fludarabine (127)  ·  Filgrastim (126)

Sponsors

National Cancer Institute (NCI) (184)  ·  Mayo Clinic (103)  ·  Celgene (93)  ·  Memorial Sloan Kettering Cancer Center (89)  ·  Fred Hutchinson Cancer Center (84)  ·  M.D. Anderson Cancer Center (80)  ·  Janssen Research & Development, LLC (68)  ·  Dana-Farber Cancer Institute (60)  ·  University of Arkansas (59)  ·  Institute of Hematology & Blood Diseases Hospital, China (49)  ·  GlaxoSmithKline (46)  ·  Amgen (42)  ·  City of Hope Medical Center (41)  ·  Washington University School of Medicine (40)  ·  Bristol-Myers Squibb (37)

Countries

United States (2537)  ·  China (484)  ·  France (435)  ·  Spain (341)  ·  Italy (331)  ·  Germany (329)  ·  Canada (281)  ·  United Kingdom (263)  ·  Australia (229)  ·  Greece (185)  ·  South Korea (172)  ·  Japan (170)  ·  Belgium (160)  ·  Netherlands (148)  ·  Israel (144)

Top investigators

Irene Ghobrial, MD (12)  ·  Brenda Sandmaier (11)

Results publications

PMID 32499241, PMID 33357481, PMID 31221778, PMID 37022569, PMID 22689675, PMID 33218965, PMID 34398557, PMID 35285981, PMID 37192741, PMID 40501401, PMID 28803351, PMID 34289038, PMID 35549810, PMID 35985959, PMID 36100310, PMID 40000533, PMID 40226119, PMID 40826257, PMID 42287565, PMID 20661232, PMID 22674807, PMID 23897961, PMID 25261096, PMID 25628469, PMID 29567784, PMID 34182226, PMID 34515338, PMID 35876974, PMID 36762851, PMID 37272512, PMID 37658205, PMID 37934000, PMID 38023148, PMID 38402374, PMID 39229471, PMID 40156952, PMID 40396505, PMID 40471585, PMID 40674744, PMID 41313549, PMID 41627370, PMID 18032762, PMID 18032763, PMID 18799726, PMID 19179301, PMID 19238148, PMID 19901114, PMID 21160068, PMID 21228328, PMID 21273172

NIH funding

2023 (73), P30CA015083 (50), U10CA180820 (45), P30CA015704 (32), 2017 (26), 2019 (25), 2018 (23), P30CA033572 (23), U24CA196172 (22), 2025 (21), U10CA032102 (21), 2014 (20), 2016 (20), P30CA006973 (20), P30CA022453 (20)