3 completed, 2 recruiting, 1 active not recruiting, 1 not yet recruiting. 4 Not applicable, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Recruiting 2, Active not recruiting 1, Completed 1 |
| Phase 2 | 2 | Completed 1, Not yet recruiting 1 |
| Phase 1 | 1 | Not yet recruiting 1 |
Follow Hereditary Spastic Paraparesis: new trials by email Literature Review of Hereditary Spastic Paraparesis trials Research Report on Hereditary Spastic Paraparesis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) BFB-101 (AAV9-CBh-AP4B1) - HSP, Hereditary Spastic Paraplegia | Phase 1 / Phase 2 | Not yet recruiting | BlackfinBio Ltd | 5 | 2025-08-01 | 2025-04-28 |
| Enhancement of Quality of Work And Life Preventive Participatory workplace intervention - Parkinson Disease, Hereditary Spastic Paraparesis | Not applicable | Active not recruiting | Radboud University Medical Center | 124 | 2024-10-08 | 2026-08-14 |
| Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast intensive reeducation - Hereditary Spastic Paraparesis | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 50 | 2024-04-04 | 2024-11-25 |
| The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children Tendoachilles (TA) lengthening or gastrocnemius (GN) recession, then Plantaris tenotomy, Plantaris tenotomy, then Tendoachilles (TA) lengthening or gastrocnemius (GN) recession - Idiopathic Toe Walking, Cerebral Palsy | Not applicable | Recruiting | University of Alberta | 42 | 2023-03-13 | 2026-03-12 |
| Testing Miglustat Administration in Subjects With Spastic Paraplegia 11 Miglustat 100 MG - Hereditary Spastic Paraparesis | Phase 2 | Completed | IRCCS Fondazione Stella Maris | 10 | 2021-06-15 | 2022-04-11 |
| SNAP: Measurement of the Subjective Perception of the Symptom in Hereditary Spastic Paraparesis (HSP) SNAP questionnaire - Hereditary Spastic Paraparesis | Not applicable | Completed | IRCCS Eugenio Medea | 80 | 2018-10-30 | 2021-11-26 |
| Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) No intervention - Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease | Completed | Massachusetts General Hospital | 475 | 2008-04-01 | 2016-06-03 |
Spastic Paraplegia, Hereditary (7) · Amyotrophic Lateral Sclerosis (1) · Brain Injuries, Traumatic (1) · Cerebellar Ataxia (1) · Cerebral Palsy (1) · Charcot-Marie-Tooth Disease (1) · Mitochondrial Diseases (1) · Motor Neuron Disease (1) · Movement Disorders (1) · Muscle Spasticity (1) · Nervous System Diseases (1) · Neurodegenerative Diseases (1) · Neuromuscular Diseases (1) · Parkinson Disease (1) · Spinal Cord Injuries (1)
Congenital Abnormalities (7) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (7) · Genetic Diseases, Inborn (7) · Hereditary Sensory and Motor Neuropathy (7) · Heredodegenerative Disorders, Nervous System (7) · Nervous System Malformations (7) · Peripheral Nervous System Diseases (7) · Polyneuropathies (7) · Nervous System Diseases (6) · Neurodegenerative Diseases (6) · Neuromuscular Diseases (6) · Central Nervous System Diseases (4) · Brain Diseases (2) · Metabolic Diseases (2) · Neurologic Manifestations (2)
miglustat (1)
Assistance Publique - Hôpitaux de Paris (1) · BlackfinBio Ltd (1) · IRCCS Eugenio Medea (1) · IRCCS Fondazione Stella Maris (1) · Massachusetts General Hospital (1) · Radboud University Medical Center (1) · University of Alberta (1)
Canada (2) · Italy (2) · United States (2) · France (1) · Netherlands (1)
Elbrich Postma, PhD (1) · Filippo M Santorelli, MD PhD (1) · James D. Berry, MD, MPH (1) · Sukhdeep Dulai, MD, MHSc, FRCSC (1)
2019 (1), 5RC1NS068179-02 (1)