173 completed, 39 terminated, 34 unknown, 20 recruiting. 303 Phase 2, 46 Phase 1, 17 Phase 3.
Follow Hepatitis B: new trials by email Literature Review of Hepatitis B trials Research Report on Hepatitis B
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Prospective Study to Evaluate the Efficacy and Safety of Entecavir ODT Conversion in Stable Liver Transplant Patients Entecavell ODT - Hepatitis B Virus, Liver Transplant | Phase 2 | Not yet recruiting | Jongman Kim | 82 | 2026-12-01 | 2026-10-28 |
| A Study of Sequential Therapy With AHB-137 Injection Followed by TVAX-008 Injection in Participants Living With Chronic Hepatitis B (CHB) AHB-137, Placebo, TVAX-008 - Chronic Hepatitis B | Phase 1 / Phase 2 | Not yet recruiting | Ausper Biopharma Co., Ltd. | 105 | 2026-10-31 | 2026-10-19 |
| A Study of Sequential Therapy With AHB-137 Injection Followed by TVAX-008 Injection in Participants Living With Chronic Hepatitis B (CHB) AHB-137, TVAX-008, Placebo - Chronic Hepatitis B | Phase 1 / Phase 2 | Not yet recruiting | Grand Theravac Life Sciences (Hangzhou) Co., Ltd. | 105 | 2026-10-31 | 2026-10-27 |
| A Study of HT-101 and HT-102 in Chronic Hepatitis B (CHB) HT-101 + HT-102, HT-101 placebo + HT-102 placebo - Chronic Hepatitis B Virus Infection | Phase 2 | Not yet recruiting | Suzhou HepaThera Biotech Co., Ltd. | 120 | 2026-10-30 | 2026-11-05 |
| Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions AHB-137 - Hepatitis B, Chronic | Phase 2 | Recruiting | AusperBio Therapeutics Inc. | 70 | 2026-09-01 | 2026-10-29 |
| Study of GST-HG131&141 Tablets Compared With Placebo in Patients With Chronic Hepatitis B GST-HG141, GST-HG131, GST-HG141 Placebo - Chronic Hepatitis B | Phase 2 | Recruiting | Fujian Akeylink Biotechnology Co., Ltd. | 80 | 2026-07-10 | 2026-07-17 |
| Bepirovirsen Liver Biopsy Study Bepirovirsen, Liver biopsy, Optional Liver biopsy - HEPATITIS B CHRONIC, Hepatitis B Chronic Infection | Phase 2 | Not yet recruiting | National University Health System, Singapore | 30 | 2026-07-01 | 2026-07-10 |
| Study of AHB-171 in Chronic Hepatitis B Participants AHB-171 Injection - Hepatitis B, Chronic (CHB) | Phase 2 | Recruiting | Ausper Biopharma Co., Ltd. | 138 | 2026-06-24 | 2026-07-21 |
| A Study to Evaluate AHB-137 Injection in Treatment-naïve Participants With Chronic Hepatitis B AHB-137, Placebo - Chronic Hepatitis B | Phase 2 | Recruiting | Ausper Biopharma Co., Ltd. | 320 | 2026-06-05 | 2026-07-29 |
| Clinical Study to Evaluate the Efficacy and Safety of HH-006 in Patients With Chronic Hepatitis B Virus Infection HH-006 - Chronic Hepatitis B Virus Infection | Phase 2 | Recruiting | Huahui Health | 45 | 2026-05-14 | 2026-06-15 |
| Phase 2 Study of AHB-137 in HBeAg Negative Chronic Hepatitis B (CHB) Participants in Asia Pacific Region AHB-137 - Hepatitis B, Chronic | Phase 2 | Recruiting | AusperBio Therapeutics Inc. | 84 | 2026-03-06 | 2026-10-13 |
| A Randomised Controlled Phase 1 Study of Vaccine Therapy for Control or Cure of Chronic Hepatitis B Virus Infection Therapeutic hepatitis B vaccine, Commercial Hepatitis B vaccine - Chronic Hepatitis b | Phase 1 / Phase 2 | Not yet recruiting | Vaxine Pty Ltd | 40 | 2026-03-01 | 2025-09-22 |
| A Phase 1/2, Open-Label, Single and Multiple Ascending Dose Study of CRMA-1001 in Adults With Chronic Hepatitis B CRMA-1001 - Chronic Hepaititis B | Phase 1 / Phase 2 | Recruiting | nChroma Bio | 66 | 2025-12-22 | 2026-06-15 |
| A Clinical Study of HT-101 and HT-102 in Patients With Chronic Hepatitis B Virus Infection HT-101, HT-102, HT-101 placebo - Chronic Hepatitis B | Phase 2 | Active not recruiting | Suzhou HepaThera Biotech Co., Ltd. | 60 | 2025-11-05 | 2026-10-29 |
| A Study to Evaluate the Efficacy and Safety of AHB-137 Injection in Participants With Chronic Hepatitis B (CHB) AHB-137, NA therapy - Chronic Hepatitis B | Phase 2 | Recruiting | Ausper Biopharma Co., Ltd. | 200 | 2025-09-04 | 2026-08-05 |
| A Phase II Clinical Study of BW-20507 in Combination With PEG-IFNα for the Treatment of Hepatitis B BW-20507 with/without NUC, BW-20507 with/without NUC, Peg-IFNa - Chronic Hepatitis B | Phase 2 | Active not recruiting | Shanghai Argo Biopharmaceutical Co., Ltd. | 209 | 2025-09-02 | 2026-01-15 |
| Zinc Sulphate in Treatment Fibrosis in HBV Patient Receiving Antiviral Therapy Entecavir (ETV), Zinc (zinc sulphate) - Liver Fibroses, HBV (Hepatitis B Virus) | Phase 2 | Not yet recruiting | Tanta University | 44 | 2025-09-01 | 2025-08-28 |
| A Study to Evaluate the Antiviral Activity and Immune Response of AHB-137 Injection in Participants With Chronic Hepatitis B (CHB) AHB-137 - Chronic Hepatitis B | Phase 2 | Active not recruiting | Ausper Biopharma Co., Ltd. | 20 | 2025-07-15 | 2026-08-10 |
| A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME) ALG-000184, TDF - Chronic Hepatitis B Infection | Phase 2 | Active not recruiting | Aligos Therapeutics | 200 | 2025-07-15 | 2026-09-11 |
| A Clinical Trial to Evaluate the Efficacy and Safety of TQA3605 Tablets in Treatment-naive Chronic HBV-infected Subjects TQA3605 tablets Placebo, TQA3605 Tablets, Entecavir dispersible tablets - Chronic Hepatitis B | Phase 2 | Withdrawn | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 2025-07-09 | 2025-08-03 |
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Hepatitis B, Chronic (188) · Tetanus (23) · Diphtheria (22) · Haemophilus Infections (19) · Hepatitis (18) · Poliomyelitis (18) · Carcinoma, Hepatocellular (12) · Whooping Cough (12) · HIV Infections (11) · Hepatitis C (9) · Bronchiolitis Obliterans Syndrome (6) · Liver Diseases (6) · Hepatitis, Chronic (5) · Liver Cirrhosis (5)
Hepadnaviridae Infections (303) · Blood-Borne Infections (301) · DNA Virus Infections (301) · Digestive System Diseases (301) · Hepatitis, Viral, Human (301) · Virus Diseases (300) · Communicable Diseases (299) · Infections (299) · Liver Diseases (297) · Hepatitis (285) · Pathological Conditions, Signs and Symptoms (196) · Pathologic Processes (195) · Disease Attributes (189) · Chronic Disease (187) · Hepatitis, Chronic (185)
entecavir (53) · Tenofovir (40) · peginterferon alfa-2a (25) · tenofovir alafenamide (17) · Hepatitis B Vaccines (10) · diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine (9) · ARC-520 (7) · adefovir dipivoxil (7) · Emtricitabine (6) · JNJ-56136379 (6) · Lamivudine (6) · hepatitis B hyperimmune globulin (6) · Engerix-B (5) · Telbivudine (5) · Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (4)
GlaxoSmithKline (36) · Gilead Sciences (19) · Ausper Biopharma Co., Ltd. (9) · National Institute of Allergy and Infectious Diseases (NIAID) (9) · Arrowhead Pharmaceuticals (8) · Assembly Biosciences (8) · Bristol-Myers Squibb (8) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (6) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (6) · Janssen Research & Development, LLC (5) · Brii Biosciences Limited (4) · F-star Therapeutics, Inc. (4) · Hoffmann-La Roche (4) · LG Chem (4) · Replicor Inc. (4)
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Guiqiang Wang (4) · Hong Ren, MM (4) · Junqi Niu (4) · Marc G Ghany, M.D. (4) · Hyo Suk Lee, M.D., Ph.D. (3) · Mamun Al-Mahtab, MD (3) · Audrey Lau, MD, PhD (2) · Don Mitchell (2)
PMID 20091678, PMID 20657177, PMID 27257978, PMID 28340322, PMID 30850240, PMID 39950613, PMID 41042426, PMID 12620148, PMID 15940636, PMID 15994231, PMID 16628625, PMID 16871563, PMID 16912304, PMID 17030856, PMID 17058225, PMID 17302367, PMID 18191272, PMID 18199519, PMID 18808318, PMID 19052126, PMID 19223649, PMID 19846955, PMID 19998272, PMID 20092990, PMID 20173677, PMID 20600025, PMID 20949113, PMID 2106474, PMID 21254162, PMID 21372751, PMID 21859559, PMID 22227229, PMID 22233350, PMID 22449251, PMID 23241989, PMID 24297682, PMID 24346596, PMID 24394187, PMID 2452123, PMID 24555998, PMID 24681228, PMID 24983020, PMID 24995515, PMID 25540274, PMID 25830171, PMID 26375468, PMID 26482090, PMID 26739688, PMID 27210427, PMID 27658693
2014 (6), 2019 (6), 2016 (4), 2023 (4), 2009 (3), 2015 (2), 2017 (2), 2018 (1), 2025 (1), P01AI055793 (1), P20CA252732 (1), U01DK058369 (1)