13 completed, 4 recruiting, 3 not yet recruiting, 3 unknown. 5 Not applicable, 2 Phase 2, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 2, Not yet recruiting 1, Recruiting 1, Unknown 1 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Phase 4 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
Follow Placental Insufficiency: new trials by email Literature Review of Placental Insufficiency trials Research Report on Placental Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Ophthalmic Artery Doppler Evaluation Prior to Labor Induction and Adverse Intrapartum Fetal Outcomes Ophthalmic Artery Doppler - Ophthalmic Artery, Labor and Delivery | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 1477 | 2026-09-24 | 2026-09-29 |
| Patterns of Aortic Isthmus Doppler in Early Fetal Growth Restriction , and the Changes in Aortic Isthmus Doppler Parameters With Every Changes of Other Early Iugr Parameters Like EFW, Uterine Artery Doppler, Cerebroplacental Ratio and Ductus Venosus Doppler in Comparison With Normal Group . Fetal Growth Restriction, Placental Insufficiency | Not yet recruiting | Assiut University | 100 | 2026-07-01 | 2026-06-30 | |
| Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial) Pravastatin 40 mg, Placebo - Preeclampsia (PE), Intrauterine Growth Restriction (IUGR) | Phase 2 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 154 | 2026-01-14 | 2026-10-16 |
| Placental Risk Assessment to CusTomize Individualized Pregnancy Care and Evaluation Data Collection Throughout Pregnancy and Delivery - Stillbirth, Placental Insufficiency | Recruiting | Oregon Health and Science University | 640 | 2025-09-18 | 2025-12-17 | |
| Placental Imaging Techniques ultrafast power Doppler imaging (uPDI) / quantitative ultrasound (QUS) - Fetal Growth Restriction (FGR), Placental Insufficiency | Not applicable | Recruiting | Carilion Clinic | 60 | 2025-04-23 | 2026-05-22 |
| Pregnancy Repository Biospecimen collection - Pregnancy Related, Fetal Growth Retardation | Not yet recruiting | Sunnybrook Health Sciences Centre | 7000 | 2024-05-01 | 2024-04-24 | |
| Speckle Tracking Echocardiography as a Tool for Early Diagnosis of Impaired Fetal Growth Twin Pregnancies sample collection - Fetal Growth Restriction, Cardiac Remodeling, Ventricular | Recruiting | University Hospital, Ghent | 360 | 2023-06-22 | 2026-09-21 | |
| Acute Effects of Maternal Exercise and the Growth Restricted Pregnancy Physical activity - Fetal Growth Retardation, Fetal Growth Complications | Completed | University of Tennessee Graduate School of Medicine | 40 | 2022-11-01 | 2026-02-03 | |
| Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency Umbilical Cord Milking - Placental Insufficiency, Preterm Infant | Not applicable | Completed | Mansoura University Children Hospital | 90 | 2019-04-01 | 2022-05-03 |
| Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency Delayed cord clamping - Preterm Infant, Placental Insufficiency | Not applicable | Completed | Mansoura University Children Hospital | 90 | 2017-09-01 | 2022-05-17 |
| Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight Testing of Alkaline Phosphatase Levels - Low Birth Weight Infants | Completed | TriHealth Inc. | 292 | 2017-06-14 | 2019-08-28 | |
| PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome Blood sampling - Pregnancy Complications, Placental Insufficiency | Unknown | Oslo University Hospital | 1000 | 2016-09-15 | 2020-12-19 | |
| Free DNA and Nucleosome Concentrations in Pathological Pregnancies Bloodwork, baseline, Blood work, Months 1 & 2, Bloodwork, Months -1 to -6 - Pregnancy, Venous Thrombosis | Completed | Centre Hospitalier Universitaire de Nīmes | 137 | 2015-06-01 | 2025-11-21 | |
| Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women Enoxaparin 40 mg / 0.4 mL Prefilled Syringe, Aspirin 100 mg Oral Tablet, Enteric Coated - Placental Insufficiency, Enoxaparin | Phase 4 | Completed | Les Laboratoires des Médicaments Stériles | 89 | 2013-10-23 | 2020-07-02 |
| Splanchnic Oxygenation Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler. Placental Insufficiency, NEC - Necrotizing Enterocolitis | Completed | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 20 | 2013-02-01 | 2016-11-23 | |
| Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Aspirin, placebo - Placental Insufficiency | Phase 2 | Completed | Sara Varea | 190 | 2012-09-01 | 2015-08-18 |
| Low Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy Enoxaparin - High Risk Pregnant Women, Placental Insufficiency | Phase 3 | Completed | Hospital Universitari Vall d'Hebron Research Institute | 361 | 2012-03-01 | 2016-12-21 |
| Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Acetylsalicylic Acid 160 mg, Acetylsalicylic Acid 80 mg - Pre-Eclampsia, Fetal Growth Retardation | Phase 4 | Completed | CHU de Quebec-Universite Laval | 104 | 2011-09-01 | 2018-11-13 |
| Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE MRI - Placental Insufficiency | Completed | Assistance Publique - Hôpitaux de Paris | 135 | 2010-02-01 | 2026-03-10 | |
| Impact of Early and Severe Fetal Growth Restriction on Neurodevelopmental Outcomes in Preterm Infants Severe Intra-uterine Growth Restriction, Preterm Birth | Unknown | Central Hospital, Nancy, France | 20 | 2010-01-01 | 2022-05-19 |
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Fetal Growth Retardation (11) · Pre-Eclampsia (9) · Premature Birth (5) · HELLP Syndrome (2) · Hypertension, Pregnancy-Induced (2) · Pregnancy Complications (2) · Stillbirth (2) · Diabetes, Gestational (1) · Eclampsia (1) · Enterocolitis, Necrotizing (1) · Fetal Death (1) · Fetofetal Transfusion (1) · Neurodevelopmental Disorders (1) · Pulmonary Embolism (1)
Female Urogenital Diseases and Pregnancy Complications (23) · Placenta Diseases (23) · Urogenital Diseases (23) · Pregnancy Complications (21) · Pathologic Processes (13) · Pathological Conditions, Signs and Symptoms (13) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Fetal Diseases (11) · Growth Disorders (11) · Hypertension, Pregnancy-Induced (7) · Obstetric Labor Complications (5) · Obstetric Labor, Premature (5) · Death (3) · Cardiovascular Diseases (2) · Fetal Death (2)
Aspirin (3) · Enoxaparin (2) · Umbilical Cord Clamping (2) · Allopurinol (1) · BaseLine dental cement (1) · Blood Specimen Collection (1) · Exercise (1) · Parturition (1) · Pravastatin (1) · Specimen Handling (1) · Tablets (1)
Assistance Publique - Hôpitaux de Paris (2) · Mansoura University Children Hospital (2) · Assiut University (1) · CHU de Quebec-Universite Laval (1) · Carilion Clinic (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Universitaire de Nīmes (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Les Laboratoires des Médicaments Stériles (1) · Oregon Health and Science University (1) · Oslo University Hospital (1) · Sara Varea (1)
France (4) · United States (4) · Spain (3) · Egypt (2) · Netherlands (2) · Belgium (1) · Canada (1) · Italy (1) · Norway (1) · Tunisia (1)
Dalenda Chelly, OB/GYN (1) · Donna Lambers, MD (1) · Elisa Llurba, MD (1) · Emmanuel Bujold, MD, MSc (1) · Eve Mousty, MD (1) · Franck Perrotin, MD-PhD (1) · Frank van Bel, Prof MD, PhD (1) · Helen Torrance, MD (1) · Karen Gibbins (1) · Kristien Roelens (1) · Laurent Salomon, MCU PH (1) · Luigi T Corvaglia, Prof (1) · Manon Benders, MD, PhD (1)
PMID 26519708, PMID 28974131, PMID 29112084, PMID 29886779, PMID 32623628, PMID 32979032, PMID 33990027, PMID 34473740, PMID 35559998
R01HD115604 (1)