10 completed. 10 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 10 |
| Phase 1 | 1 | Completed 1 |
Follow Giant Cell Tumors: new trials by email Literature Review of Giant Cell Tumors trials Research Report on Giant Cell Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate Safety and Efficacy of AMB-05X Injections in Subjects With TGCT AMB-05X - Pigmented Villonodular Synovitis, TGCT | Phase 2 | Completed | AmMax Bio, Inc. | 20 | 2023-01-26 | 2024-07-05 |
| An Open-Label Study of Intra-articular AMB-05X Injections in Subjects With Tenosynovial Giant Cell Tumor of the Knee AMB-05X - Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis (PVNS) | Phase 2 | Completed | AmMax Bio, Inc. | 11 | 2021-05-25 | 2024-06-27 |
| A Study of Pexidartinib in Tenosynovial Giant Cell Tumor in Japan Pexidartinib - Tenosynovial Giant Cell Tumor | Phase 2 | Completed | Daiichi Sankyo Co., Ltd. | 9 | 2021-03-15 | 2026-06-24 |
| Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor FPA008 - Pigmented Villonodular Synovitis, Tenosynovial Giant Cell Tumor | Phase 1 / Phase 2 | Completed | Five Prime Therapeutics, Inc. | 66 | 2015-06-01 | 2021-08-31 |
| MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) MCS110, Placebo - Pigmented Villonodular Synovitis, PVNS | Phase 2 | Completed | Novartis Pharmaceuticals | 36 | 2012-04-23 | 2021-01-05 |
| Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Tasigna - Pigmented Villonodular Synovitis | Phase 2 | Completed | Centre Leon Berard | 50 | 2010-12-01 | 2013-04-16 |
| Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor nilotinib - Pigmented Villonodular Synovitis, Diffuse-type Giant Cell Tumor | Phase 2 | Completed | Andrew J. Wagner, MD, PhD | 17 | 2010-09-01 | 2026-02-20 |
| Study of Denosumab in Subjects With Giant Cell Tumor of Bone Denosumab - Cancer, Giant Cell Tumors | Phase 2 | Completed | Amgen | 535 | 2008-09-09 | 2022-09-22 |
| Trial of Dasatinib in Advanced Sarcomas Dasatinib - Rhabdomyosarcoma, Malignant Peripheral Nerve Sheath Tumors | Phase 2 | Completed | Sarcoma Alliance for Research through Collaboration | 366 | 2007-05-01 | 2018-11-23 |
| Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone Denosumab, Calcium/Vitamin D - GCT, Giant Cell Tumor of Bone | Phase 2 | Completed | Amgen | 37 | 2006-07-10 | 2022-11-08 |
Synovitis, Pigmented Villonodular (7) · Giant Cell Tumor of Tendon Sheath (6) · Giant Cell Tumor of Bone (3) · Chondrosarcoma (1) · Chordoma (1) · Gastrointestinal Stromal Tumors (1) · Hemangiopericytoma (1) · Neoplasms (1) · Neurofibrosarcoma (1) · Rhabdomyosarcoma (1) · Sarcoma (1) · Sarcoma, Alveolar Soft Part (1) · Sarcoma, Ewing (1) · Solitary Fibrous Tumors (1)
Neoplasms by Histologic Type (10) · Neoplasms, Connective Tissue (10) · Neoplasms, Connective and Soft Tissue (10) · Neoplasms (9) · Joint Diseases (7) · Muscular Diseases (7) · Musculoskeletal Diseases (7) · Synovitis (7) · Tendinopathy (7) · Neoplasms, Bone Tissue (3) · Digestive System Diseases (1) · Digestive System Neoplasms (1) · Fibrosarcoma (1) · Gastrointestinal Diseases (1)
Denosumab (2) · nilotinib (2) · Calcium (1) · Dasatinib (1) · Vitamin D (1) · cabiralizumab (1) · pexidartinib (1)
AmMax Bio, Inc. (2) · Amgen (2) · Andrew J. Wagner, MD, PhD (1) · Centre Leon Berard (1) · Daiichi Sankyo Co., Ltd. (1) · Five Prime Therapeutics, Inc. (1) · Novartis Pharmaceuticals (1) · Sarcoma Alliance for Research through Collaboration (1)
United States (7) · Netherlands (5) · Poland (4) · France (3) · United Kingdom (3) · Australia (2) · Italy (2) · Austria (1) · Canada (1) · Germany (1) · Japan (1) · South Korea (1) · Spain (1) · Sweden (1) · Switzerland (1)
Dorothy Nguyen, MD (2) · Andrew J. Wagner, MD, PhD (1) · Jean Yves Blay, PR (1) · Scott Schuetze, MD, PhD (1)
PMID 25684041, PMID 29211870, PMID 29571946, PMID 30231890, PMID 33482769, PMID 35932628