5 recruiting, 4 active not recruiting, 2 completed, 2 terminated. 5 Not applicable, 4 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Recruiting 3, Completed 1, Not yet recruiting 1 |
| Phase 2 | 4 | Terminated 2, Active not recruiting 1, Recruiting 1 |
| Phase 1 | 3 | Active not recruiting 1, Recruiting 1, Terminated 1 |
Follow FTD: new trials by email Literature Review of FTD trials Research Report on FTD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment Temporal Interference Stimulation, Sham Temporal Interference Stimulation, Targeted Cognitive Training - Amnestic Mild Cognitive Impairment - aMCI, AD-MCI | Not applicable | Recruiting | Tianjin Huanhu Hospital | 60 | 2026-07-01 | 2026-06-11 |
| Metabolic Characterization of Alzheimer's Disease and Frontotemporal Dementia by 23Na-MRI and FDG-PET Sodium MRI - FTD, AD | Not applicable | Not yet recruiting | Centre Hospitalier St Anne | 55 | 2025-10-01 | 2025-08-03 |
| Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases Alzheimer Disease, FTD | Recruiting | Ospedale Policlinico San Martino | 1200 | 2025-02-28 | 2025-11-25 | |
| Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches ALS (Amyotrophic Lateral Sclerosis), FTD | Active not recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 230 | 2025-02-27 | 2026-08-28 | |
| Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration Theta burst stimulation, Sham Theta burst stimulation - FTLD, FTD | Not applicable | Recruiting | Università degli Studi di Brescia | 120 | 2025-02-13 | 2026-01-05 |
| Genetics and Environment iNtersection In the ALS-FTD Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach multiomic profile to assess genetic and environmental risk factiors - ALS, FTD | Unknown | Azienda Ospedaliero-Universitaria di Modena | 45 | 2024-01-29 | 2025-02-04 | |
| A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) Intrathalamic AAV.PGRN administration, Intrathalamic AVB-101 - Frontotemporal Dementia, FTD | Phase 1 / Phase 2 | Recruiting | AviadoBio Ltd | 18 | 2023-08-30 | 2026-08-13 |
| A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes PAMSys, LEGSys - PSP, CBD | Active not recruiting | Massachusetts General Hospital | 60 | 2023-07-28 | 2026-01-21 | |
| Nabilone for Agitation in Frontotemporal Dementia Nabilone, Placebo - Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant | Phase 2 | Terminated | Simon Ducharme, MD | 3 | 2023-03-07 | 2026-07-28 |
| Neurofilament Light Chains and Cognitive Impairment in Chronic Psychiatric Disease blood sample taken - Schizophrenia, Bipolar Disorder | Not applicable | Recruiting | Hôpital le Vinatier | 120 | 2021-10-22 | 2025-07-24 |
| A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes PBFT02 - Frontotemporal Dementia, FTD | Phase 1 / Phase 2 | Active not recruiting | Passage Bio, Inc. | 30 | 2021-09-14 | 2026-05-15 |
| Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD) WVE-004, Placebo - ALS, FTD | Phase 1 / Phase 2 | Terminated | Wave Life Sciences USA, Inc. | 35 | 2021-06-28 | 2023-10-23 |
| Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders C-11 PiB, AV1451 Tau, C-11 ER176 - PSP, CBD | Enrolling by invitation | Mayo Clinic | 500 | 2020-11-01 | 2025-11-21 | |
| Neurofilament Surveillance Project (NSP) Frontotemporal Dementia, Frontotemporal Lobar Degeneration | Active not recruiting | The Bluefield Project to Cure Frontotemporal Dementia | 342 | 2020-09-02 | 2026-06-18 | |
| Voices Of Individuals: Challenges and Experiences Of bvFTD Telephone Interview - Frontotemporal Dementia, Frontotemporal Degeneration | Completed | University of Pennsylvania | 26 | 2019-06-26 | 2026-01-12 | |
| tDCS Intervention in Primary Progressive Aphasia Active HD-tDCS plus Speech-Language Therapy, Sham plus Speech-Language Therapy - Primary Progressive Aphasia, MCI | Not applicable | Completed | Johns Hopkins University | 61 | 2013-04-01 | 2025-01-28 |
Frontotemporal Dementia (9) · Pick Disease of the Brain (4) · Alzheimer Disease (3) · Aphasia, Primary Progressive (3) · Dementia (3) · Frontotemporal Dementia With Motor Neuron Disease (3) · Frontotemporal Lobar Degeneration (3) · Amyotrophic Lateral Sclerosis (2) · Parkinson Disease (2) · Aphasia (1) · Apraxias (1) · Bipolar Disorder (1) · Corticobasal Degeneration (1) · Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia (1) · Mental Disorders (1)
Brain Diseases (13) · Central Nervous System Diseases (13) · Nervous System Diseases (13) · Mental Disorders (12) · Neurocognitive Disorders (12) · Neurodegenerative Diseases (12) · Metabolic Diseases (11) · Nutritional and Metabolic Diseases (11) · Proteostasis Deficiencies (11) · TDP-43 Proteinopathies (11) · Dementia (10) · Frontotemporal Lobar Degeneration (7) · Neurologic Manifestations (5) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5)
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · Interviews as Topic (1) · Speech Therapy (1) · nabilone (1)
AviadoBio Ltd (1) · Azienda Ospedaliero-Universitaria di Modena (1) · Centre Hospitalier St Anne (1) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (1) · Hôpital le Vinatier (1) · Johns Hopkins University (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Ospedale Policlinico San Martino (1) · Passage Bio, Inc. (1) · Simon Ducharme, MD (1) · The Bluefield Project to Cure Frontotemporal Dementia (1) · Tianjin Huanhu Hospital (1) · University of Pennsylvania (1) · Università degli Studi di Brescia (1)
United States (7) · Italy (5) · Canada (4) · Australia (2) · Belgium (2) · Netherlands (2) · Sweden (2) · United Kingdom (2) · Brazil (1) · China (1) · France (1) · Ireland (1) · New Zealand (1) · Poland (1) · Portugal (1)
Adam Boxer, MD, PhD (1) · Bradley Boeve, MD (1) · Howie Rosen, MD (1) · Jill Owczarzak, PhD (1) · Kyrana Tsapkini, PhD (1) · Laura Mitic, PhD (1) · Lori Erby, PhD, ScM (1) · Will Chou, MD (1)
PMID 30258975, PMID 33031971, PMID 34875098, PMID 37287321
2023 (1), R01DC014475 (1)