32 recruiting, 30 completed, 17 terminated, 14 unknown. 109 Phase 1, 40 Phase 2.
Follow Esophageal Squamous Cell Carcinoma: new trials by email Literature Review of Esophageal Squamous Cell Carcinoma trials Research Report on Esophageal Squamous Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of ASP388B Given by Itself and With Standard Therapies in Participants With Solid Tumors ASP388B, Pembrolizumab, Carboplatin - Locally Advanced or Metastatic Solid Tumors | Phase 1 / Phase 2 | Recruiting | Astellas Pharma Global Development, Inc. | 392 | 2026-09-02 | 2026-10-26 |
| A Study of IDP-001 in Advanced or Metastatic Solid Tumors IDP-001 - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 / Phase 2 | Recruiting | InduPro, Inc. | 132 | 2026-07-08 | 2026-09-03 |
| Becotatug Vedotin Plus Cisplatin and Radiotherapy in LA-ESCC Becotatug Vedotin Combined with Cisplatin and Concurrent Radiotherapy - Esophageal Squamous Cell Carcinoma | Phase 1 | Not yet recruiting | Hebei Medical University Fourth Hospital | 12 | 2026-07-01 | 2026-07-10 |
| A Study of IPM514 in Patients With Esophageal Squamous Cell Carcinoma. IPM514 - Esophageal Squamous Cell Carcinoma | Phase 1 | Not yet recruiting | Beijing Immupeutics Medicine Technology Limited | 36 | 2026-06-30 | 2025-10-02 |
| A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F) I-DXd, Rescue Medication - Oesophageal Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 60 | 2026-03-27 | 2026-10-02 |
| A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors IDE892, IDE397 - NSCLC Adenocarcinoma, Gastroesophageal Cancer (GC) | Phase 1 | Recruiting | IDEAYA Biosciences | 260 | 2026-03-04 | 2026-09-28 |
| A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types IDE034 - Esophageal Squamous Cell Carcinoma, High Grade Serous Ovarian Cancer | Phase 1 | Recruiting | IDEAYA Biosciences | 150 | 2026-02-24 | 2026-06-18 |
| 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors 177Lu-BetaBart, BetaBart + unlabeled BetaBart - Castration-Resistant Prostate Cancer (CRPC), Colorectal Cancer | Phase 1 / Phase 2 | Recruiting | Radiopharm Theranostics, Ltd | 61 | 2026-02-23 | 2026-10-01 |
| A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC AK112, AK112 + Neoadjuvant chemotherapy - Esophageal Squamous Cell Carcinoma, Ivonescimab | Phase 1 / Phase 2 | Recruiting | Tang-Du Hospital | 45 | 2026-01-28 | 2026-02-03 |
| First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors PLX-61639 - Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma | Phase 1 | Recruiting | Plexium, Inc. | 155 | 2025-12-01 | 2026-06-12 |
| A Phase 1/1b of RNDO-564 Single Agent or in Combination With Pembrolizumab in Bladder Cancer and Other Solid Tumors Associated With Nectin-4 RNDO-564, Pembrolizumab - Non Small Cell Lung Cancer, Cervical Cancer | Phase 1 | Enrolling by invitation | Rondo Therapeutics | 149 | 2025-11-17 | 2026-06-11 |
| A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas EVOLVE104 - Bladder Cancer, Squamous Cell Carcinoma of the Lung | Phase 1 | Recruiting | EvolveImmune United, Inc | 160 | 2025-11-13 | 2026-09-15 |
| A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors KIVU-107 - Advance Solid Tumors | Phase 1 | Recruiting | Kivu Bioscience Inc. | 76 | 2025-11-13 | 2026-09-24 |
| A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations TER-2013, Fulvestrant injection - Breast Cancer, Endometrial Cancer | Phase 1 / Phase 2 | Recruiting | Terremoto Biosciences Inc. | 248 | 2025-09-23 | 2026-10-28 |
| Endostatin Adenovirus With Checkpoint Inhibitor in Advanced Head and Neck or Esophageal Cancer recombinant human endostatin adenovirus, PD-1 Inhibitor - Esophageal Cancer, Head and Neck Cancer (H&Amp;Amp;Amp;N) | Phase 1 | Not yet recruiting | Sichuan University | 40 | 2025-09-01 | 2025-09-04 |
| A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors PF-08046876, Pembrolizumab, Cisplatin - Advanced/Metastatic Solid Tumors, Bladder Cancer | Phase 1 | Recruiting | Pfizer | 540 | 2025-08-20 | 2026-10-13 |
| A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors ALX2004 - NSCLC (Advanced Non-small Cell Lung Cancer), HNSCC | Phase 1 | Recruiting | ALX Oncology Inc. | 170 | 2025-08-18 | 2026-09-30 |
| Oncolytic Virus in Esophageal Squamous Cell Carcinoma Oncolytic Virus: Administered via intratumoral injection (metastatic lesions in the neck or supraclavicular lymph nodes) once every 3 weeks, for a total of two to four doses., Oncolytic Virus: Administered via intratumoral injection (primary lesions) once every 3 weeks, for a total of two to four doses. - Esophageal Cancer | Phase 1 / Phase 2 | Recruiting | Sichuan University | 40 | 2025-08-01 | 2025-12-08 |
| Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06) Pembrolizumab, I-DXd, Leucovorin - Esophageal Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 298 | 2025-07-30 | 2026-10-27 |
| Neoadjuvant Immunotherapy Combined With Chemotherapy Sequenced With Endoscopic Resection for Esophageal Cancer (Endosurgery-02) Tislelizumab, Carboplatin, Nab-paclitaxel - Esophageal Squamous Cell Carcinoma (ESCC) | Phase 1 | Recruiting | Shanghai Zhongshan Hospital | 60 | 2025-07-15 | 2026-01-05 |
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Squamous Cell Carcinoma of Head and Neck (35) · Carcinoma, Non-Small-Cell Lung (31) · Esophageal Neoplasms (28) · Adenocarcinoma Of Esophagus (26) · Colorectal Neoplasms (17) · Stomach Neoplasms (16) · Uterine Cervical Neoplasms (16) · Triple Negative Breast Neoplasms (14) · Melanoma (13) · Neoplasm Metastasis (12) · Ovarian Neoplasms (11) · Small Cell Lung Carcinoma (11) · Carcinoma, Hepatocellular (10) · Endometrial Neoplasms (10)
Digestive System Diseases (109) · Digestive System Neoplasms (109) · Gastrointestinal Diseases (109) · Gastrointestinal Neoplasms (109) · Neoplasms by Histologic Type (109) · Neoplasms by Site (109) · Neoplasms, Glandular and Epithelial (109) · Carcinoma (108) · Esophageal Diseases (108) · Neoplasms, Squamous Cell (108) · Neoplasms (107) · Carcinoma, Squamous Cell (106) · Head and Neck Neoplasms (104) · Esophageal Neoplasms (81) · Lung Diseases (37)
pembrolizumab (17) · Cisplatin (16) · Fluorouracil (14) · Radiotherapy (13) · Paclitaxel (12) · Carboplatin (11) · Oxaliplatin (10) · Irinotecan (9) · Docetaxel (7) · 130-nm albumin-bound paclitaxel (5) · Nivolumab (5) · Drug Therapy (4) · Leucovorin (4) · Neoadjuvant Therapy (4) · spartalizumab (4)
Novartis Pharmaceuticals (6) · Merck Sharp & Dohme LLC (4) · Memorial Sloan Kettering Cancer Center (3) · Seagen, a wholly owned subsidiary of Pfizer (3) · Sichuan University (3) · Sun Yat-sen University (3) · Exelixis (2) · Hebei Medical University Fourth Hospital (2) · Hoffmann-La Roche (2) · IDEAYA Biosciences (2) · Incyte Corporation (2) · Jacobio Pharmaceuticals Co., Ltd. (2) · National Cancer Institute (NCI) (2) · Peking University (2) · Radiopharm Theranostics, Ltd (2)
United States (59) · China (36) · Spain (19) · South Korea (18) · France (15) · Japan (14) · Taiwan (14) · United Kingdom (12) · Germany (10) · Italy (10) · Singapore (10) · Australia (9) · Belgium (9) · Canada (7) · Netherlands (6)
David H. Ilson, MD, PhD (2) · Admasu Mamuye, MD (1) · Afshin Dowlati, MD (1) · Amelie Deleporte, Physician (1) · Andreas Kaubisch (1) · Andrew Ko, MD (1) · Arthur Blackstock (1) · Daniel Fowler, M.D. (1)
PMID 42580817, PMID 12049861, PMID 12885811, PMID 18845990, PMID 19738454, PMID 21205757, PMID 21926976, PMID 22245781, PMID 23553066, PMID 23658246, PMID 24360117, PMID 25904751, PMID 26254683, PMID 26808342, PMID 28446503, PMID 28537764, PMID 28742685, PMID 28899363, PMID 29409469, PMID 29441562, PMID 29623552, PMID 29861116, PMID 30372581, PMID 31236579, PMID 31319389, PMID 32143580, PMID 32396014, PMID 33065643, PMID 33373868, PMID 33492986, PMID 33613701, PMID 33941878, PMID 34137505, PMID 34454674, PMID 34688250, PMID 35623069, PMID 35671803, PMID 36158679, PMID 36322089, PMID 36969745, PMID 37433041, PMID 37489066, PMID 37619980, PMID 38148327, PMID 40819238, PMID 41309527, PMID 41423415, PMID 42028290, PMID 42320980
2023 (6), 2019 (4), 2015 (1), 2016 (1), 2018 (1), 2025 (1), N01CM62204 (1), P30CA008748 (1), P30CA043703 (1), UM1CA186712 (1)