12 completed, 8 recruiting, 3 active not recruiting, 3 enrolling by invitation. 6 Phase 2, 6 Phase 3, 4 Not applicable, 1 Early Phase 1, 1 Phase 1.
Follow Eosinophilic Esophagitis (EoE): new trials by email Literature Review of Eosinophilic Esophagitis (EoE) trials Research Report on Eosinophilic Esophagitis (EoE)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of Upadacitinib for Non-responsive Eosinophilic Esophagitis Upadacitinib 30mg Dose, Upadacitinib Matching Placebo - EoE, Eosinophilic Esophagitis | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 52 | 2026-09-30 | 2026-10-06 |
| Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions EndoFlip - Dysphagia, Esophageal Stricture | Not applicable | Recruiting | Johns Hopkins University | 25 | 2026-07-24 | 2026-08-24 |
| The DiNAM-EoE-C Study: Esophageal Distensibility and Novel Assessment of Motility in Eosinophilic Esophagitis Eosinophilic Esophagitis (EoE), Dysphagia, Esophageal | Enrolling by invitation | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 25 | 2026-05-01 | 2026-07-29 | |
| Trial of Partial Enteral Nutrition With Dairy Free Diet in Eosinophilic Esophagitis Partial enteral nutrition (PEN) with dairy elimination, Dairy elimination alone - Eosinophilic Esophagitis (EoE) | Not applicable | Recruiting | Kate Farms Inc | 36 | 2026-03-18 | 2026-04-16 |
| Comparison of Eohilia With Dupixent on Esophagus Diameter in Patients With Eosinophilic Esophagitis. Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT], budesonide oral suspension - Eosinophilic Esophagitis (EoE) | Early Phase 1 | Enrolling by invitation | Mayo Clinic | 60 | 2026-02-04 | 2026-05-04 |
| A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis dupilumab - Eosinophilic Esophagitis (EoE) | Phase 3 | Recruiting | Regeneron Pharmaceuticals | 20 | 2025-11-10 | 2026-09-29 |
| Natural History of Eosinophilic Esophagitis in Adult and Pediatric Population Eosinophilic Esophagitis (EoE) | Recruiting | Fondazione IRCCS Policlinico San Matteo di Pavia | 200 | 2025-09-01 | 2026-06-29 | |
| Surface EMG Testing on Swallowing in EoE Patients Surface Electromyography, Fiberoptic Endoscopic Evaluation of Swallowing - Eosinophilic Esophagitis (EoE) | Active not recruiting | Mayo Clinic | 30 | 2025-08-04 | 2026-07-17 | |
| Trans-Cervical and Trans-abdominal Ultrasound for Monitoring Esophageal Thickness in Eosinophilic Esophagitis Trans cervical or abdominal ultrasound - Eosinophilic Esophagitis (EoE) | Not applicable | Not yet recruiting | Sheba Medical Center | 100 | 2025-08-01 | 2025-07-29 |
| BURDEN OF ESOPHAGEAL CANCER IN EOSINOPHILIC ESOPHAGITIS (ESCAPE STUDY) Eosinophilic Esophagitis (EoE) | Completed | IRCCS San Raffaele | 100000 | 2025-07-23 | 2026-03-11 | |
| Local Clinical and Immunological Responses in Eosinophilic Esophagitis (EoE) Patients, Role of Mucosal Barrier Function and Type II Inflammation Eosinophilic Esophagitis (EoE) | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 56 | 2025-07-01 | 2025-06-10 | |
| Tolerability of Baked Dairy Protein in Eosinophilic Esophagitis Patients With Cow Milk Protein Trigger baked milk product diet - Eosinophilic Esophagitis (EoE) | Not applicable | Enrolling by invitation | Shaare Zedek Medical Center | 20 | 2025-03-01 | 2025-05-22 |
| A U.S. Registry of Eosinophilic Esophagitis Pediatric, Adolescent and Adult Patients Treated With DUPIXENT® As Standard of Care dupilumab - Eosinophilic Esophagitis (EoE) | Active not recruiting | Regeneron Pharmaceuticals | 368 | 2024-11-22 | 2026-08-12 | |
| Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE) Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT] - Eosinophilic Esophagitis (EoE) | Phase 4 | Recruiting | University of California, San Diego | 30 | 2024-11-10 | 2024-12-11 |
| A Study to Investigate the Efficacy and Safety of NSI-8226 in Adults With Eosinophilic Esophagitis Solrikitug Low Dose, Solrikitug Mid Dose, Solrikitug High Dose - Eosinophilic Esophagitis (EoE) | Phase 2 | Active not recruiting | Uniquity One (UNI) | 184 | 2024-10-16 | 2026-03-20 |
| New Cases of EoE in Children in Poland. Data collection - Eosinophilic Disorder, Eosinophilic Esophagitis (EoE) | Completed | Medical University of Warsaw | 250 | 2024-06-01 | 2026-08-19 | |
| Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy Esophageal String Test - Eosinophilic Esophagitis (EoE) | Recruiting | Children's Hospital of Philadelphia | 75 | 2024-04-01 | 2025-05-29 | |
| SAD, MAD and Food Effect Evaluation of Safety, Tolerability, and PK of AQ280 in Healthy Subjects AQ280, Placebo - Eosinophilic Esophagitis (EoE) | Phase 1 | Completed | AQILION AB | 66 | 2022-07-20 | 2024-12-24 |
| Prostaglandin and Cannabinoid Receptors in EoE Biopsy samples, Blood samples - Eosinophilic Esophagitis (EoE) | Completed | Medical University of Graz | 45 | 2021-07-01 | 2025-05-02 | |
| Study to Investigate the Efficacy and Safety of Dupilumab in Pediatric Patients With Active Eosinophilic Esophagitis (EoE) Dupilumab, Matching Placebo - Eosinophilic Esophagitis (EoE) | Phase 3 | Completed | Regeneron Pharmaceuticals | 102 | 2020-09-01 | 2025-10-27 |
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Eosinophilic Esophagitis (29) · Deglutition Disorders (4) · Gastroesophageal Reflux (2) · Barrett Esophagus (1) · Deception (1) · Dilatation, Pathologic (1) · Eosinophilia (1) · Epidermolysis Bullosa (1) · Esophageal Achalasia (1) · Esophageal Diseases (1) · Esophageal Motility Disorders (1) · Esophageal Neoplasms (1) · Esophageal Stenosis (1) · Esophagitis (1) · Inflammation (1)
Digestive System Diseases (29) · Gastroenteritis (29) · Gastrointestinal Diseases (29) · Hematologic Diseases (29) · Hemic and Lymphatic Diseases (29) · Hypersensitivity (29) · Hypersensitivity, Immediate (29) · Immune System Diseases (29) · Leukocyte Disorders (29) · Eosinophilia (28) · Esophageal Diseases (28) · Esophagitis (28) · Otorhinolaryngologic Diseases (4) · Pharyngeal Diseases (4) · Deglutition Disorders (2)
dupilumab (5) · Bethanechol (1) · Blood Specimen Collection (1) · Budesonide (1) · Data Collection (1) · Electromyography (1) · Endoscopy, Digestive System (1) · Fluticasone (1) · penclomedine (1) · upadacitinib (1)
Shire (5) · Mayo Clinic (3) · Regeneron Pharmaceuticals (3) · AQILION AB (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Philadelphia (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · IRCCS San Raffaele (1) · Johns Hopkins University (1) · Kate Farms Inc (1) · Medical University of Graz (1) · Medical University of Warsaw (1) · Shaare Zedek Medical Center (1)
United States (20) · Italy (4) · Netherlands (2) · Poland (2) · United Kingdom (2) · Australia (1) · Austria (1) · Belgium (1) · Canada (1) · Israel (1) · Spain (1) · Switzerland (1)
Alberto Barchi, MD (1) · Andrew W Lee, MD (1) · Diana Snyder, M.D. (1) · Evan S Dellon, MD, MPH (1) · Jeffrey A Alexander (1) · Jennifer Horsley-Silva, M.D. (1) · Jonathan M Spergel, MD, PhD (1) · Karthik Ravi, MD (1) · Kenneth Ng, DO (1) · Marc E Rothenberg, MD, PhD (1) · Mary Allyson Lowry, MD (1) · Michael Pickens, DO (1)
PMID 34182150, PMID 37718471, PMID 39735351, PMID 41711386, PMID 24907502, PMID 27889574, PMID 29902649, PMID 30502508, PMID 32272243, PMID 33887475, PMID 35666852, PMID 36863390, PMID 38924731, PMID 39631042, PMID 39954913, PMID 41534558, PMID 41749054, PMID 42031097, PMID 42100495
2019 (1), R01DK146043 (1), T32DK007673 (1), U54AI117804 (1)