12 completed, 3 withdrawn, 1 recruiting, 1 terminated. 17 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Completed 12, Withdrawn 3, Recruiting 1, Terminated 1 |
| Phase 2 | 4 | Completed 3, Withdrawn 1 |
Follow Drug Abuse: new trials by email Literature Review of Drug Abuse trials Research Report on Drug Abuse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Oral THC and CBD in Men and Women Placebo, THC, CBD - Drug Abuse, Intoxication by Drug | Phase 1 | Recruiting | University of California, Los Angeles | 22 | 2026-08-13 | 2026-09-08 |
| Evaluation of Smoked THC and CBD in Men and Women Placebo Cannabis, 20 mg CBD Cannabis, 20 mg CBD + 20 mg THC Cannabis - Drug Abuse, Intoxication by Drug | Phase 1 | Completed | University of California, Los Angeles | 19 | 2022-09-01 | 2026-03-20 |
| Determination the Abuse Potential of Pitolisant in Healthy, Non-Dependent Recreational Stimulant Users Pitolisant, Placebos, Phentermine - Healthy, Drug Abuse | Phase 1 | Completed | Bioprojet | 43 | 2017-03-15 | 2017-11-13 |
| Crossover Study to Evaluate the Abuse Potential of Intranasal Esketamine Compared to Racemic Intravenous Ketamine in Nondependent, Recreational Drug Users Intravenous placebo, Intranasal placebo, Intravenous racemic ketamine - Drug Abuse | Phase 1 | Completed | Janssen Research & Development, LLC | 55 | 2016-03-25 | 2025-04-27 |
| A Study to Evaluate Abuse Potential of Istradefylline Istradefylline, Phentermine 45 mg, Placebo - Drug Abuse | Phase 1 | Completed | Kyowa Kirin Co., Ltd. | 42 | 2016-01-01 | 2024-04-25 |
| Trial of Computerized MET for Adolescent Substance Use iMET, MET - Drug Abuse, Alcohol Abuse | Phase 1 | Withdrawn | Boston Children's Hospital | 2013-10-01 | 2017-04-12 | |
| A Study to Assess the Abuse Potential of Hydrocodone Extended-Release Tablet in Recreational Opioid Users 45-mg hydrocodone bitartrate extended-release tablet (crushed or intact), Placebo - Drug Abuse | Phase 1 | Completed | Cephalon | 100 | 2012-03-01 | 2012-11-21 |
| Study in Healthy Recreational Polydrug Users to Measure the Abuse Potential of TC-5214 TC-5214, TC-5214 Placebo, Ketamine - Drug Abuse, Healthy | Phase 1 | Withdrawn | AstraZeneca | 2012-01-01 | 2012-03-22 | |
| cSBIRT to Reduce Teen Tobacco, Alcohol and Drug Use Computer Screening, Brief Intervention, Referral toTreatment - Tobacco Abuse, Alcohol Abuse | Phase 1 / Phase 2 | Withdrawn | Boston Children's Hospital | 2011-09-01 | 2016-10-07 | |
| Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use iMET, iMET/TE - Use; Tobacco, Harmful, Alcohol Abuse | Phase 1 / Phase 2 | Completed | Boston Children's Hospital | 121 | 2010-09-01 | 2016-10-07 |
| Oral Fluid, Plasma and Whole Pharmacokinetics and Stability Following Smoked Cannabis Cannabis Cigarette - Cannabis Use, Drug Abuse | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 45 | 2010-01-22 | 2018-07-05 |
| Prevention of Post Sexual Assault Stress PPRS, PIRI - Drug Use, Drug Abuse | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 245 | 2009-05-01 | 2016-04-13 |
| Abuse Potential of Single Doses of Lorcaserin in Healthy Recreational Polydrug Users Placebo, Active Comparator #1, Active Comparator #2 - Drug Abuse, Healthy | Phase 1 | Completed | Eisai Inc. | 35 | 2008-12-01 | 2019-09-12 |
| Disulfiram Interactions With HIV Medications: Clinical Implications Disulfiram, Disulfiram + Efavirenz, Disulfiram + Atazanavir - HIV Infections, Drug Abuse | Phase 1 | Completed | University of California, San Francisco | 40 | 2008-11-01 | 2014-05-06 |
| Behavioral Therapy Development for Methamphetamine Abuse Cognitive Behavioral Therapy Development for Methamphetamine Abuse - Depression, Drug Abuse | Phase 1 | Terminated | University of California, Los Angeles | 2004-08-01 | 2016-01-27 | |
| Cognitive Behavioral Stress Management for HIV+ Drug Abusers Cognitive Behavioral Stress Management - HIV/AIDS, Drug Abuse | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 450 | 1999-09-01 | 2017-01-11 |
| Acute Intervention to Reduce Distress Following Sexual Assault PPRS - Drug Use, Drug Abuse | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 442 | 1997-03-01 | 2015-04-22 |
Substance-Related Disorders (17) · Alcoholism (4) · Tobacco Use Disorder (3) · Marijuana Abuse (2) · Stress Disorders, Post-Traumatic (2) · Tobacco Use (2) · Acquired Immunodeficiency Syndrome (1) · Depression (1) · HIV Infections (1) · Medication Adherence (1) · Sexually Transmitted Diseases (1)
Chemically-Induced Disorders (17) · Mental Disorders (17) · Alcohol-Related Disorders (4) · Behavior (4) · Communicable Diseases (3) · Genital Diseases (3) · Infections (3) · Urogenital Diseases (3) · Blood-Borne Infections (2) · Immune System Diseases (2) · Immunologic Deficiency Syndromes (2) · Lentivirus Infections (2) · RNA Virus Infections (2) · Retroviridae Infections (2) · Sexually Transmitted Diseases (2)
Phentermine (3) · histaminol (2) · Atazanavir Sulfate (1) · Crisis Intervention (1) · Disulfiram (1) · Dronabinol (1) · Esketamine (1) · Hydrocodone (1) · Ketamine (1) · Mass Screening (1) · Ritonavir (1) · efavirenz (1) · istradefylline (1) · pitolisant (1)
Boston Children's Hospital (3) · University of California, Los Angeles (3) · Medical University of South Carolina (2) · National Institute on Drug Abuse (NIDA) (2) · AstraZeneca (1) · Bioprojet (1) · Cephalon (1) · Eisai Inc. (1) · Janssen Research & Development, LLC (1) · Kyowa Kirin Co., Ltd. (1) · University of California, San Francisco (1)
United States (13) · Canada (3)
Heidi Resnick, Ph.D. (2) · John R. Knight, MD (2) · Brendan Smyth, MD (1) · Elinore F McCance-Katz, M.D., Ph.D (1) · Hans A Eriksson, MD (1) · James A Peck, Psy.D. (1) · James A. Peck, PsyD. (1) · Marilyn Huestis, Ph.D. (1) · Michael B. McDonnell, MD (1) · Pierre Geoffroy, MDCM, MSC, FCFP (1) · Robert M. Malow, PhD (1) · Sion K Harris, PhD (1)
PMID 33605440, PMID 21412231, PMID 31242340, PMID 31622944, PMID 31626696, PMID 33128208, PMID 37286883, PMID 37795783
R01DA011158 (1), R01DA023099 (1), R01DA024982 (1)