31 completed, 4 active not recruiting, 4 withdrawn, 3 recruiting. 16 Phase 4, 10 Phase 2, 8 Not applicable, 7 Phase 1, 2 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1 Therapy Discontinuation Phentermine Pill, Orforglipron - Obesity | Phase 4 | Not yet recruiting | Massachusetts General Hospital | 60 | 2026-11-01 | 2026-07-27 |
| Phentermine's Impact on Treatment in Teens Phentermine, Placebo - Childhood Obesity | Phase 2 | Recruiting | Russell McCulloh, MD | 240 | 2026-06-03 | 2026-10-07 |
| Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease Transjugular Intrahepatic Portosystemic Shunt (TIPS), Sleeve Gastrectomy, Anti-Obesity Pharmacotherapy (Class Effect) - Liver Cirrhoses, Portal Hypertension Related to Cirrhosis | Phase 4 | Recruiting | The Cleveland Clinic | 70 | 2025-12-17 | 2026-10-22 |
| Treating Toddler Obesity by Treating the Parent/Caregiver Obesity With Weight Loss Medications Lomaira 8Mg Tablet - Weight Loss, Obesity, Childhood | Phase 4 | Withdrawn | Loma Linda University | 2025-12-01 | 2025-11-20 | |
| Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity Phentermine / Topiramate Extended Release Oral Capsule [Qsymia], Placebo - Hypothalamic Obesity, Hypothalamic Tumor | Phase 2 | Active not recruiting | Seattle Children's Hospital | 24 | 2025-03-01 | 2026-10-16 |
| Intermittent Phentermine for Obesity and Body Composition Phentermine 15 MG, Phentermine 30 mg, Phentermine 37.5 Mg - Obesity & Overweight | Phase 4 | Completed | OSCAR MANUEL TORRES FALCON | 600 | 2024-03-01 | 2026-10-13 |
| Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery Topiramate, Phentermine, Placebo - Obesity | Phase 4 | Recruiting | University of California, Irvine | 120 | 2023-08-29 | 2026-10-19 |
| Anti-obesity Pharmacotherapy and Inflammation Semaglutide, Phentermine-Topiramate combination, Phentermine - Obesity | Active not recruiting | Louisiana State University Health Sciences Center in New Orleans | 30 | 2023-06-01 | 2025-09-09 | |
| Phentermine/Topiramate in Adolescents With Type 2 Diabetes and Obesity Phentermine/Topiramate (Qsymia), Placebo - Pediatric Obesity | Early Phase 1 | Active not recruiting | University of Minnesota | 13 | 2022-07-07 | 2026-05-22 |
| Long-term Effectiveness of the Antiobesity Medication Phentermine Online Lifestyle Behavioral Therapy, Phentermine Hydrochloride 8 MG - Obesity, Obesity; Drug | Phase 4 | Active not recruiting | Wake Forest University Health Sciences | 870 | 2022-06-30 | 2026-03-31 |
| Medications After Adolescent Bariatric Surgery Topiramate, Phentermine - Pediatric Obesity | Phase 2 | Withdrawn | Janey Pratt | 2022-06-01 | 2025-05-31 | |
| A Study of VI-0521 on Ambulatory Blood Pressure (ABPM) in Overweight or Obese Subjects VI-0521, Phentermine, Placebo - Blood Pressure | Phase 4 | Completed | VIVUS LLC | 565 | 2022-01-25 | 2024-07-17 |
| Phentermine/Topiramate for Uric Acid Stones Phentermine / Topiramate Oral Product, Citrate Salts, Allopurinol, Diet - Obesity, Uric Acid Stones | Phase 2 | Completed | University of Florida | 19 | 2021-03-31 | 2026-06-15 |
| Comparing a Virtual vs. Face to Face Weight Management Program Using Phentermine for Patients With Overweight or Obesity Phentermine 37.5 Mg, Dietary program, Exercise program - Obesity | Phase 4 | Completed | The Cleveland Clinic | 70 | 2021-01-01 | 2022-12-07 |
| EMI-EHP Weight Management and Type 2 Diabetes Pragmatic Trial Weight Management Program (WMP), Traditional care, Phentermine / Topiramate Extended Release Oral Capsule - Type 2 Diabetes, Obesity | Phase 4 | Terminated | The Cleveland Clinic | 74 | 2020-09-01 | 2024-09-19 |
| Adjunct Phentermine + Topiramate After Bariatric Surgery in 12-24 Year Olds Phentermine, Immediate Release Topiramate, Placebo for Phentermine - Obesity, Morbid, Bariatric Surgery | Phase 2 | Completed | University of Colorado, Denver | 13 | 2020-01-15 | 2025-05-23 |
| SMART Use of Medication for the Treatment of Adolescent Severe Obesity Lifestyle Modification Therapy (LSMT), Phentermine Pill, Topiramate Pill - Adolescent Obesity | Phase 2 | Completed | University of Minnesota | 150 | 2019-11-21 | 2026-05-05 |
| Use of Medication to Improve Weight Loss in Suboptimal Early Responders to Behavioral Treatment Behavioral Treatment, Placebo, Phentermine 15 MG - Obesity | Phase 4 | Completed | University of Pennsylvania | 147 | 2019-07-15 | 2025-03-11 |
| Orlistat/Phentermine Versus Placebo/Phentermine Orlistat 120Mg Cap, Phentermine Pill - Obesity, Overweight | Not applicable | Completed | Gangnam Severance Hospital | 114 | 2018-10-16 | 2019-11-04 |
| Effectiveness and Tolerability of Phentermine in Patients Under Bariatric Surgery Phentermine, Placebo - Obesity, Morbid Obesity | Phase 4 | Completed | Hospital Juarez de Mexico | 92 | 2018-03-01 | 2020-07-29 |
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Obesity (28) · Overweight (7) · Weight Loss (7) · Pediatric Obesity (5) · Obesity, Morbid (3) · Substance-Related Disorders (3) · Hyperglycemia (2) · Insulin Resistance (2) · Metabolic Syndrome (2) · Anorexia (1) · Appetitive Behavior (1) · Binge-Eating Disorder (1) · Body Weight (1) · Body Weight Changes (1) · Bulimia (1)
VIVUS LLC (5) · Vegenat, S.A. (4) · The Cleveland Clinic (3) · AstraZeneca (2) · University of Minnesota (2) · University of Pennsylvania (2) · Wake Forest University Health Sciences (2) · AdventHealth Translational Research Institute (1) · Bioprojet (1) · Center for Weight Management, California (1) · Denver Health and Hospital Authority (1) · Dr. Michael Lang (1) · Eisai Inc. (1) · Gangnam Severance Hospital (1) · Hospital Juarez de Mexico (1)
United States (35) · Spain (4) · Mexico (2) · Canada (1) · South Korea (1)
Alfonso Mesejo, PhD (1) · Ali Aminian, MD (1) · Andres J Acosta (1) · Bartolome Burguera (1) · Benjamin Canales, MD (1) · Brendan Smyth, MD (1) · Chris Galloway, MD (1) · Christian L Roth, MD (1) · Claudia Fox, MD, MPH (1) · Craig Peterson (1) · Craig R Rush, Ph.D. (1) · Daniel H Bessesen, MD (1) · Debra L Safer, MD (1) · Ed J Hendricks, MD (1)
PMID 21593294, PMID 25590212, PMID 26549276, PMID 28440045, PMID 29038069, PMID 29363287, PMID 29980535, PMID 30257072, PMID 30421856, PMID 30902750, PMID 30926955, PMID 31241358, PMID 31485965, PMID 31626696, PMID 31721257, PMID 32313674, PMID 33688228, PMID 33759389, PMID 33826697, PMID 36156456, PMID 38304225, PMID 40055520
P30DK048520 (1), R01DA032254 (1), R01DK119456 (1), R01DK129936 (1), R01HL029188 (1), R21DK122317 (1), U24DK132740 (1), U24OD038400 (1), UG3HL155801 (1)