13 completed, 10 unknown, 7 recruiting, 4 not yet recruiting. 20 Not applicable, 6 Phase 2, 2 Phase 1, 2 Phase 3, 1 Phase 4.
Follow Chemotherapy-Related Cognitive Impairment: new trials by email Literature Review of Chemotherapy-Related Cognitive Impairment trials Research Report on Chemotherapy-Related Cognitive Impairment
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT N-Acetyl-Cysteine, Placebo - Ovarian Cancer, Cognitive Impairment | Phase 1 / Phase 2 | Recruiting | University of California, Irvine | 102 | 2026-05-21 | 2026-07-17 |
| Impact of Supplementation With Synbiotics and Prebiotics on Cognitive Decline Associated With Neoadjuvant Chemotherapy in First-line Patients With Breast Cancer Synbiotics Blend, Synbiotics + Vitamin D, Prebiotic - Chemobrain, Breast Cancer | Not applicable | Enrolling by invitation | Instituto Jalisciense de Cancerologia | 80 | 2026-02-27 | 2026-03-12 |
| Cognitive Training and Exercise for Women With Breast Cancer and Cognitive Impairment Cognitive training, Psychoeducational therapy - Breast Cancer | Not applicable | Not yet recruiting | Universidad de Extremadura | 220 | 2025-09-01 | 2025-06-12 |
| Evaluating Cognitive Changes on Patients in Chemotherapy (ECCPC) Low-Intensity Walking Intervention, Control Group Intervention - Chemotherapy-related Cognitive Impairment | Phase 3 | Enrolling by invitation | Ellis Medicine | 100 | 2025-06-09 | 2025-08-12 |
| Evaluation of Cognitive Education Activities in Breast Cancer Patients Receiving Chemotherapy Cognitive Function Training Activities - Breast Cancer, Chemotherapy-related Cognitive Impairment | Not applicable | Completed | Saglik Bilimleri Universitesi | 108 | 2025-03-03 | 2026-05-06 |
| Behavior Change Wheel-Based Music Listening for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients BCW-Based Music Listening Intervention, Routine Nursing Care - Breast Cancer, Chemotherapy-Related Cognitive Impairment | Not applicable | Completed | The First Affiliated Hospital with Nanjing Medical University | 90 | 2025-03-01 | 2026-06-11 |
| Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer Gastroesophageal Cancer (GC), Postoperative Delirium (POD) | Recruiting | Karolinska Institutet | 130 | 2025-02-13 | 2026-08-11 | |
| JUMP Prevalence of Sarcopenia and Chemobrain in Post-cancer Patients Study of the adverse effects of long-term oncological treatments, Study of the long-term side effects of oncological treatments on the anxiety-depressive and cognitive state of patients - Cancer, Sarcopenia | Recruiting | Hospices Civils de Lyon | 100 | 2025-02-10 | 2025-11-21 | |
| Cognitive Impairment in Treated Breast Cancer Survivors: Possible Approaches 1. cognitive stimulation, 2. psychoeducation and cognitive stimulation, 3. no intervention - Cognitive Impairment, Chemobrain | Not applicable | Not yet recruiting | Grigore T. Popa University of Medicine and Pharmacy | 120 | 2024-11-01 | 2024-10-30 |
| Effects of DL-3-n-butylphthalide on Chemotherapy-Induced Cognitive Impairment DL-3-n-butylphthalide, Empty Medication Capsules - Chemotherapy-Related Cognitive Impairment, DL-3-n-butylphthalide | Phase 4 | Not yet recruiting | First Hospital of China Medical University | 100 | 2024-07-01 | 2024-07-18 |
| CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG) Neurotablet® and Neuropsychological evaluations, Neuropsychological evaluations - Breast Cancer | Not applicable | Unknown | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 128 | 2024-06-01 | 2024-05-30 |
| Aerobic Dance During Chemotherapy in Breast Cancer Patients With Cognitive Impairment Aerobic dance, Fast-walking - Breast Neoplasms, Exercise Therapy | Not applicable | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 90 | 2024-04-01 | 2024-02-20 |
| eHealth Interventions for Breast Cancer Cognitive Impairment ICOgnition - Breast Cancer, Cognitive Dysfunction | Not applicable | Unknown | Institut Català d'Oncologia | 176 | 2024-03-14 | 2024-03-06 |
| Electroacupuncture for Chemotherapy-Related Cognitive Impairment Electroacupuncture, Sham acupuncture - Chemotherapy-Related Cognitive Impairment | Phase 2 | Unknown | Beijing University of Chinese Medicine | 100 | 2023-08-01 | 2023-07-14 |
| Technological Gaming in Cancer Survivors (WINNERS) Video game based training - Survivors of Childhood Cancer | Not applicable | Unknown | Antonio Pérez Martínez | 56 | 2023-02-23 | 2024-03-15 |
| Ashwagandha for Cognitive Dysfunction Ashwagandha, Placebo - Chemo Fog | Phase 2 | Unknown | Sutter Health | 80 | 2023-01-01 | 2023-06-15 |
| nCCR for Chemotherapy Related Cognitive Impairment Randomized Study Neuroplasticity-based Computerized Cognitive Remediation, Active Control Condition - Chemo-brain, Chemotherapy-Related Cognitive Impairment | Not applicable | Active not recruiting | University of Massachusetts, Worcester | 50 | 2022-08-01 | 2026-01-08 |
| Cognitive Stimulation and Chemobrain. An Innovative Intervention for Cancer Survivors Personalized cognitive stimulation, Sham cognitive stimulation - Breast Cancer, Cognitive Decline | Not applicable | Unknown | Universidad Antonio de Nebrija | 120 | 2022-06-03 | 2022-06-08 |
| Investigating Cognitive Impairment in Young Patients With Cancer Prospectively Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity | Recruiting | Copenhagen University Hospital, Rigshospitalet | 100 | 2022-03-01 | 2023-05-03 | |
| GM1 Prophylaxis for Post-chemotherapy Cognitive Impairment in Patients With Early Operable Breast Cancer Ganglioside-Monosialic Acid, 250ml normal saline (NS) - Chemotherapy-Related Cognitive Impairment, Breast Cancer | Phase 3 | Terminated | Sun Yat-sen University | 76 | 2022-02-08 | 2024-08-01 |
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Breast Neoplasms (19) · Cognitive Dysfunction (13) · Neoplasms (5) · Cognition Disorders (3) · Depression (2) · Lymphoma, Non-Hodgkin (2) · Memory Disorders (2) · Motor Activity (2) · Sarcopenia (2) · Colorectal Neoplasms (1) · Emergence Delirium (1) · Fatigue (1) · Frailty (1) · Hodgkin Disease (1)
Chemically-Induced Disorders (39) · Drug-Related Side Effects and Adverse Reactions (39) · Mental Disorders (39) · Neurocognitive Disorders (39) · Cognition Disorders (36) · Cognitive Dysfunction (26) · Neoplasms by Site (22) · Neoplasms (21) · Breast Diseases (19) · Skin Diseases (19) · Skin and Connective Tissue Diseases (19) · Nervous System Diseases (6) · Behavior (4) · Neurologic Manifestations (4) · Pathological Conditions, Signs and Symptoms (4)
Cognitive Training (2) · 3-n-butylphthalide (1) · Acetylcysteine (1) · Ashwagandha (1) · Cyclophosphamide (1) · Doxorubicin (1) · Drug Therapy (1) · Electroacupuncture (1) · Functional Status (1) · High-Intensity Interval Training (1) · Magnetic Resonance Spectroscopy (1) · Mesna (1) · Neuroprotective Agents (1) · Palliative Care (1) · Prebiotics (1)
The First Affiliated Hospital with Nanjing Medical University (2) · Vanderbilt University Medical Center (2) · Antonio Pérez Martínez (1) · Beijing University of Chinese Medicine (1) · Bright Cloud International Corp (1) · Celgene Corporation (1) · Charite University, Berlin, Germany (1) · Copenhagen University Hospital, Rigshospitalet (1) · Ellis Medicine (1) · First Hospital of China Medical University (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Grigore T. Popa University of Medicine and Pharmacy (1) · Hospices Civils de Lyon (1) · Institut Català d'Oncologia (1) · Institute of Oncology Ljubljana (1)
United States (18) · China (3) · Spain (3) · Austria (1) · Denmark (1) · France (1) · Germany (1) · Mexico (1) · Slovenia (1) · Sweden (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Barbara Collins (1) · Carol Parise, PhD (1) · Cristian Ochoa Arnedo, PhD (1) · Daniela Bota, MD, PhD (1) · Debbie Anglade, PhD, MSN, RN (1) · Deepti Behl, MD (1) · Donna Posluszny, PhD (1) · Grigore C Burdea, PhD (1) · Guang Yue, PhD (1) · Henry W Mahncke, PhD (1) · Jay F Piccirillo, MD (1) · Jennifer N Vega, PhD (1)
PMID 17518411, PMID 18551510, PMID 19085975, PMID 25909710, PMID 35133982, PMID 35401389, PMID 37202143, PMID 39070895, PMID 40892751, PMID 41106863, PMID 41685666
R01CA244673 (1), R43CA232936 (1)