9 recruiting, 3 not yet recruiting, 2 completed. 7 Not applicable, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Recruiting 6, Completed 1 |
| Phase 2 | 1 | Recruiting 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Disorders of Consciousness Due to Severe Brain Injury: new trials by email Literature Review of Disorders of Consciousness Due to Severe Brain Injury trials Research Report on Disorders of Consciousness Due to Severe Brain Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Walking With Overground Robotic Exoskeleton Device to Increase Behavioral Responsiveness in Patients With Disorders of Consciousness (WALK DOC) Overground Robotic Exoskeleton (ORE) - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Not yet recruiting | Spaulding Rehabilitation Hospital | 18 | 2026-11-01 | 2026-09-21 | |
| Comprehensive Assessment of Rehabilitation Experience Using the SAFE Scale Caregiver training and administration of SAFE scale, Standard clinical care - Caregiver Anxiety, Acquired Brain Injury | Not applicable | Recruiting | Fondazione Don Carlo Gnocchi ETS | 68 | 2026-07-15 | 2026-11-03 |
| Prognostication of Recovery in Early Disorders of Consciousness Study MRI, EEG - Disorders of Consciousness Due to Severe Brain Injury | Not yet recruiting | Massachusetts General Hospital | 50 | 2026-07-01 | 2026-04-24 | |
| Vagus Nerve Stimulation in Patients in Comatose State Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS) - Traumatic Brain Injury, Severe Traumatic Brain Injury | Not applicable | Recruiting | Sima Mofakham | 10 | 2026-06-26 | 2026-07-22 |
| Promoting Recovery After Brain Injury Using Focused Ultrasound Low-intensity focused ultrasound - Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury | Not applicable | Recruiting | Massachusetts General Hospital | 36 | 2026-05-26 | 2026-06-15 |
| fNIRS for Disorders of Consciousness Functional Near-Infrared Spectroscopy Monitoring - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Recruiting | University of California, Los Angeles | 55 | 2026-05-01 | 2026-06-08 | |
| Transcutaneous Electrical Acupoint Stimulation at Jing-Well Points for Disorders of Consciousness Transcutaneous electrical stimulation, Sham electrical stimulation - Disorders of Consciousness Due to Severe Brain Injury | Phase 2 / Phase 3 | Recruiting | Xijing Hospital | 160 | 2026-04-20 | 2026-08-05 |
| Assessment of Consciousness With CRS-R and SECONDs Simplified Evaluation of CONsciousness Disorders (SECONDs), Coma Recovery Scale-Revised (CRS-R) - Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State | Recruiting | BDH-Klinik Hessisch Oldendorf | 110 | 2026-02-01 | 2026-03-11 | |
| Assessment of Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Disorders of Consciousness Next Generation Dome Helmet (NGDH) - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 10 | 2025-09-10 | 2026-07-09 |
| Hand Jing-Well Points Stimulation to Treat Disorders of Consciousness Bloodletting Acupuncture, Transcutaneous electrical stimulation - Disorders of Consciousness Due to Severe Brain Injury | Not applicable | Completed | Xijing Hospital | 59 | 2025-05-12 | 2026-07-15 |
| Ultrasound Stimulation for Patients in a Disorder of Consciousness The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain. - Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury | Not applicable | Recruiting | University of California, Los Angeles | 60 | 2025-04-26 | 2026-05-22 |
| the Prediction Value of Combined Electroencephalographic and Electromyographic Response in Disorders of Consciousness thermal stimulation, itch - Disorders of Consciousness Due to Severe Brain Injury | Not yet recruiting | KY20242235jiangwen | 36 | 2025-04-15 | 2025-04-11 | |
| Consciousness Prognosis Evaluation Using Olfactory Stimulations in Comatose Patients) Olfactory stimulation - Disorders of Consciousness Due to Severe Brain Injury | Not applicable | Recruiting | Centre Hospitalier St Anne | 96 | 2024-02-05 | 2025-08-17 |
| Peripheral Nerve Stimulation for Prognostic and Diagnostic Biomarker Identification in Disorders of Consciousness Disorders of Consciousness Due to Severe Brain Injury | Completed | Fondazione Don Carlo Gnocchi ETS | 28 | 2022-07-21 | 2025-08-24 |
Consciousness Disorders (9) · Brain Injuries, Traumatic (4) · Coma (4) · Persistent Vegetative State (4) · Brain Injuries (3) · Hypoxia, Brain (2) · Stroke (2) · Coma, Post-Head Injury (1) · Disease (1)
Nervous System Diseases (11) · Neurobehavioral Manifestations (10) · Neurologic Manifestations (10) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (10) · Mental Disorders (9) · Neurocognitive Disorders (9) · Brain Diseases (6) · Central Nervous System Diseases (6) · Craniocerebral Trauma (6) · Trauma, Nervous System (6) · Wounds and Injuries (6) · Unconsciousness (5) · Brain Damage, Chronic (4) · Brain Injuries (3)
Transcutaneous Electric Nerve Stimulation (2) · Electroencephalography (1) · UBE3A protein, human (1)
Fondazione Don Carlo Gnocchi ETS (2) · Massachusetts General Hospital (2) · University of California, Los Angeles (2) · Xijing Hospital (2) · BDH-Klinik Hessisch Oldendorf (1) · Centre Hospitalier St Anne (1) · KY20242235jiangwen (1) · Sima Mofakham (1) · Spaulding Rehabilitation Hospital (1) · Sunnybrook Health Sciences Centre (1)
United States (5) · China (2) · Italy (2) · Canada (1) · France (1) · Germany (1)
Bahia Hakiki (1) · Brian L Edlow, MD (1) · Chad Swank, PhD (1) · Martin M Monti, PhD (1) · Melanie Boltzmann, PhD (1)
PMID 16186047, PMID 16350986, PMID 17671503, PMID 19954851, PMID 20679291, PMID 21777872, PMID 21876461, PMID 21886108, PMID 22224835, PMID 2252964, PMID 22725684, PMID 24239121, PMID 24273723, PMID 24413698, PMID 24574549, PMID 25480912, PMID 27567470, PMID 28195954, PMID 28901969, PMID 30765166, PMID 30941094
K23NS140495 (1), R61MH138612 (1)