13 completed, 4 active not recruiting, 4 recruiting, 1 unknown. 23 Phase 2, 6 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 23 | Completed 13, Active not recruiting 4, Recruiting 4, Unknown 1, Withdrawn 1 |
| Phase 1 | 6 | Completed 4, Recruiting 2 |
| Phase 3 | 1 | Active not recruiting 1 |
Follow Desmoid Tumors: new trials by email Literature Review of Desmoid Tumors trials Research Report on Desmoid Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study in Adults With Desmoid Tumors ES014 - Desmoid Tumor | Phase 2 | Recruiting | Elpiscience (Suzhou) Biopharma, Ltd. | 50 | 2026-04-24 | 2026-10-21 |
| A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) Nirogacestat oral tablet - Desmoid Tumor, Aggressive Fibromatosis | Phase 2 | Active not recruiting | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany | 20 | 2025-08-08 | 2026-09-15 |
| Study of Cryoablation and Nirogacestat for Desmoid Tumor Nirogacestat, Cryoablation - Desmoid Tumor | Phase 2 | Recruiting | Nam Bui | 28 | 2023-08-15 | 2026-09-10 |
| FOG-001 in Locally Advanced or Metastatic Solid Tumors FOG-001, mFOLFOX-6, Nivolumab - Cancer, Colorectal Cancer | Phase 1 / Phase 2 | Recruiting | Parabilis Medicines, Inc. | 619 | 2023-05-23 | 2026-10-07 |
| Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors Biospecimen Collection, Dual X-ray Absorptiometry, Tegavivint - Colorectal Carcinoma, Endometrial Carcinoma | Phase 1 / Phase 2 | Recruiting | Children's Oncology Group | 147 | 2021-11-08 | 2026-08-25 |
| A Study of AL102 in Patients With Progressing Desmoid Tumors AL102, Placebo - Desmoid, Desmoid Tumor | Phase 2 / Phase 3 | Active not recruiting | Immunome, Inc. | 198 | 2021-09-01 | 2026-06-08 |
| A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery Biospecimen Collection, Computed Tomography, Echocardiography Test - Desmoid Fibromatosis, Recurrent Desmoid Fibromatosis | Phase 2 | Active not recruiting | Children's Oncology Group | 31 | 2020-10-07 | 2026-10-01 |
| A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor vactosertib/imatinib combination - Desmoid Tumor | Phase 1 / Phase 2 | Completed | Hyo Song Kim | 24 | 2019-04-15 | 2024-05-13 |
| Doxorubicin Eluting Intra-arterial Embolization for Aggressive Desmoid Fibromatosis Drug Eluting Bead Embolization (DEB) for Desmoid Fibromatosis - Desmoid, Desmoid Fibromatosis of Skin | Phase 2 | Completed | Rabin Medical Center | 8 | 2018-10-11 | 2022-03-25 |
| Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers Nab-Rapamycin, Nivolumab - Ewing Sarcoma, PEComa | Phase 1 / Phase 2 | Completed | Sarcoma Oncology Research Center, LLC | 34 | 2017-08-24 | 2025-02-17 |
| Trial of Nab-paclitaxel in Patients With Desmoid Tumors and Multiply Relapsed/Refractory Desmoplastic Small Round Cell Tumors and Ewing Sarcoma nab paclitaxel - Tumor, Desmoplastic Small Round Cell, Adult, Tumor, Desmoplastic Small Round Cell, Childhood | Phase 2 | Completed | Grupo Espanol de Investigacion en Sarcomas | 69 | 2017-05-09 | 2022-06-07 |
| Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Biospecimen Collection, Computed Tomography, Echocardiography Test - Acinar Cell Carcinoma, Adenoid Cystic Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 798 | 2017-01-30 | 2026-06-17 |
| A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis Sirolimus - Desmoid Tumor | Phase 1 / Phase 2 | Completed | MaineHealth | 9 | 2014-02-01 | 2023-06-26 |
| Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive Fibromatosis PF-03084014 - Desmoid Tumors, Aggressive Fibromatosis | Phase 2 | Completed | National Cancer Institute (NCI) | 17 | 2013-10-31 | 2024-02-06 |
| Toremifene in Desmoid Tumor: Prospective Clinical Trial and Identification of Potential Molecular Targets Toremifene - Desmoid Type-fibromatosis | Phase 2 | Unknown | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 25 | 2012-11-01 | 2015-02-02 |
| Study to Evaluate Imatinib in Desmoid Tumors Imatinib - Aggressive Fibromatosis, Desmoid Tumor | Phase 2 | Completed | Heidelberg University | 39 | 2010-06-01 | 2017-05-03 |
| Effect of Hydroxyurea as Treatment for Primary Desmoid Tumors Hydroxyurea - Desmoid Tumors, Fibromatosis | Phase 2 | Withdrawn | Children's Hospital of Philadelphia | 2009-10-01 | 2017-04-20 | |
| Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas sunitinib malate - Adult Malignant Fibrous Histiocytoma of Bone, Desmoid Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 53 | 2007-04-01 | 2016-01-20 |
| Imatinib Mesylate in Treating Patients With Recurrent or Refractory Fibromatosis imatinib mesylate - Desmoid Tumor | Phase 1 / Phase 2 | Completed | UNICANCER | 40 | 2004-09-01 | 2016-08-30 |
| Sulindac and Tamoxifen in Treating Patients With Desmoid Tumor tamoxifen citrate, sulindac, laboratory biomarker analysis - Desmoid Tumor | Phase 2 | Completed | Children's Oncology Group | 70 | 2004-02-01 | 2020-02-19 |
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Carcinoma, Hepatocellular (3) · Colorectal Neoplasms (3) · Endometrial Neoplasms (3) · Sarcoma (3) · Sarcoma, Ewing (3) · Carcinoma, Transitional Cell (2) · Chordoma (2) · Desmoplastic Small Round Cell Tumor (2) · Fibroma (2) · Hemangiosarcoma (2) · Melanoma (2) · Neoplasms (2) · Neurofibrosarcoma (2) · Osteosarcoma (2)
Neoplasms by Histologic Type (23) · Neoplasms, Connective Tissue (23) · Neoplasms, Connective and Soft Tissue (23) · Neoplasms, Fibrous Tissue (23) · Fibroma (21) · Neoplasms (21) · Female Urogenital Diseases (5) · Female Urogenital Diseases and Pregnancy Complications (5) · Neoplasms by Site (5) · Neoplasms, Germ Cell and Embryonal (5) · Neoplasms, Glandular and Epithelial (5) · Neoplasms, Nerve Tissue (5) · Neuroectodermal Tumors (5) · Urogenital Diseases (5) · Urogenital Neoplasms (5)
nirogacestat (4) · Nivolumab (3) · Specimen Handling (3) · Imatinib Mesylate (2) · Magnetic Resonance Spectroscopy (2) · Phantoms, Imaging (2) · Toremifene (2) · X-Rays (2) · Absorptiometry, Photon (1) · Albumin-Bound Paclitaxel (1) · Bevacizumab (1) · Bone Density (1) · CTLA-4 Antigen (1) · Cryosurgery (1) · Fluorouracil (1)
Children's Oncology Group (4) · National Cancer Institute (NCI) (2) · Advocate Lutheran General Hospital (1) · Children's Hospital of Philadelphia (1) · Elpiscience (Suzhou) Biopharma, Ltd. (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (1) · Grupo Espanol de Investigacion en Sarcomas (1) · Heidelberg University (1) · Hyo Song Kim (1) · Immunome, Inc. (1) · MaineHealth (1) · Memorial Sloan Kettering Cancer Center (1) · Nam Bui (1) · Parabilis Medicines, Inc. (1)
United States (13) · Australia (4) · Germany (3) · Belgium (2) · Canada (2) · France (2) · Israel (2) · Italy (2) · Netherlands (2) · Poland (2) · South Korea (2) · Spain (2) · United Kingdom (2) · China (1) · Guam (1)
Aaron R Weiss, DO (1) · Benjamin Oshrine (1) · Bernd Kasper, PD Dr. med. (1) · Brian L. Samuels, MD (1) · Bruce Himelstein, MD (1) · Chiara Colombo, MD (1) · Erlinda M Gordon, MD (1) · Fariba Navid (1) · Francisco Bautista, MD (1) · Geraldine H O'Sullivan Coyne, M.D. (1) · Jaume Mora, MD (1) · Javier Martin Broto, MD (1) · Jean-Yves Blay, MD, PhD (1)
PMID 17290057, PMID 19451429, PMID 20622000, PMID 24089446, PMID 26602014, PMID 26861905, PMID 28282612, PMID 28350521, PMID 31401903, PMID 31969335, PMID 33362722, PMID 33882143, PMID 34380663, PMID 34716198, PMID 38243705, PMID 38358334, PMID 39067873, PMID 39343510, PMID 39417692, PMID 39583952, PMID 39856213, PMID 39956770, PMID 40402690, PMID 40588371, PMID 41672597, PMID 41892875, PMID 41903360, PMID 41995270, PMID 42499790
2016 (1), P30CA008748 (1), U10CA098543 (1), U10CA180886 (1), U10CA180888 (1), UM1CA228823 (1)