7 completed, 3 unknown, 2 recruiting, 1 active not recruiting. 7 Not applicable, 6 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 5, Unknown 2 |
| Phase 3 | 6 | Completed 2, Recruiting 2, Active not recruiting 1, Not yet recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RB-PDT for Fusarium Keratitis: The LUMIERE Study Rose Bengal Photodynamic Therapy, Sham RB-PDT - Fusarium Keratitis | Phase 3 | Not yet recruiting | Stanford University | 434 | 2027-01-01 | 2026-08-17 |
| Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A Cyclosporine A, Placebo Comparator: Placebo - Fungal Keratitis, Corneal Ulcer | Phase 3 | Recruiting | University of California, San Francisco | 150 | 2025-09-01 | 2026-06-05 |
| Parasitic Ulcer Treatment Trial Polyhexamethylene biguanide (PHMB), Topical corticosteroid, Topical placebo - Acanthamoeba Keratitis | Phase 3 | Recruiting | Jeremy Keenan, MD, MPH | 232 | 2024-07-01 | 2026-10-01 |
| Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II Difluprednate Ophthalmic, Rose Bengal, Moxifloxacin Ophthalmic - Bacterial Keratitis | Phase 3 | Active not recruiting | University of California, San Francisco | 60 | 2024-07-01 | 2026-08-17 |
| Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin - Acanthamoeba Keratitis, Fungal Keratitis | Phase 3 | Completed | University of California, San Francisco | 330 | 2022-08-03 | 2026-09-03 |
| Evaluation of Nanodropper-mediated Microdrops vs. Standard Drops of 0.5% Timolol Maleate in Glaucoma Patients Nanodropper adaptor, Original eyedrop bottle/No Nanodropper - Glaucoma, Glaucoma, Open-Angle | Not applicable | Completed | Nanodropper, Inc. | 420 | 2021-11-06 | 2023-01-18 |
| Steroids and Cross-linking for Ulcer Treatment Moxifloxacin Ophthalmic, Difluprednate Ophthalmic, Riboflavin Ophthalmic - Keratitis Bacterial | Phase 3 | Completed | Thomas M. Lietman | 280 | 2020-09-24 | 2025-02-03 |
| Perfecting Refraction in India With Superior Service Models School Model, Referral Model, Referral Model + Cost Recovery - Refractive Error | Not applicable | Completed | Sun Yat-sen University | 162 | 2019-08-12 | 2024-10-30 |
| Investigation of the Accuracy of a Low-cost, Portable, Autorefractor to Provide Well-tolerated Eyeglass Prescriptions QuickSee refractive error assessment + glasses - Refractive Errors | Not applicable | Completed | Johns Hopkins University | 400 | 2017-12-15 | 2020-07-21 |
| PROductivity Study of Presbyopia Elimination in Rural-dwellers (PROSPER) Intervention group, Control Group - Presbyopia | Not applicable | Completed | Congdon Nathan | 751 | 2017-07-24 | 2017-12-27 |
| Corneal Ulcer Prevention Through Health Education Health Education - Corneal Ulcer | Unknown | Aravind Eye Care System | 98207 | 2014-12-01 | 2014-11-06 | |
| Study of Effectiveness of Telemedicine in Identifying Diabetic Retinopathy Cases Tele-medicine, Conventional referral - Diabetic Retinopathy | Not applicable | Completed | Aravind Eye Care System | 801 | 2014-05-01 | 2015-04-22 |
| Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis collagen crosslinking group, Topical anti-fungal therapy - Mycotic Corneal Ulcer | Not applicable | Unknown | Aravind Eye Care System | 20 | 2014-02-01 | 2014-12-31 |
| Evaluation of the Efficacy of 2% Cyclosporine in Preventing Graft Rejection Prednisolone acetate1%,, Prednisolone acetate1%, cyclosporine 2% - Corneal Graft Rejection | Not applicable | Unknown | Aravind Eye Care System | 200 | 2012-02-01 | 2014-08-01 |
Corneal Ulcer (3) · Acanthamoeba Keratitis (2) · Refractive Errors (2) · Diabetic Retinopathy (1) · Glaucoma (1) · Glaucoma, Open-Angle (1) · Myopia (1) · Ocular Hypertension (1) · Presbyopia (1)
Corneal Cross-Linking (3) · Natamycin (2) · Rose Bengal (2) · Adrenal Cortex Hormones (1) · Control Groups (1) · Cyclosporine (1) · Eyeglasses (1) · Telemedicine (1) · Voriconazole (1) · chlorhexidine gluconate (1) · polihexanide (1) · prednisolone acetate (1)
India (13) · Brazil (4) · United States (4) · United Kingdom (1)
Jennifer Rose-Nussbaumer, MD (3) · Nicole Varnado, MPH (3) · Nathan Congdon (2) · Tom Lietman, MD (2) · Astrid Fletcher, MSc, PhD (1) · David Friedman, MD, MPH, PhD (1) · Dr. Venkatesh Prajna, DNB,FRCS (1) · Dr.Anita Raghavan (1) · Gerami D Seitzman, MD (1) · Gerami Seitzman, MD (1) · Jennifer Steger, PhD (1) · Jeremy Keenan, MD, MPH (1) · Priya Adhisesha Reddy (1) · Ramasamy Kim, DO, DNB (1) · Sanil Joseph, MHA, MSc (1)
PMID 21508106, PMID 23109740, PMID 25841317, PMID 26190438, PMID 30049615, PMID 31070699, PMID 32557558, PMID 34901464, PMID 34942106, PMID 38112645, PMID 39011096, PMID 39192339, PMID 40705354, PMID 41561665, PMID 42348235
UG1EY028518 (2), UG1EY033284 (1)