10 completed, 4 not yet recruiting, 4 unknown, 3 recruiting. 6 Not applicable, 3 Phase 3, 3 Phase 4, 2 Phase 2, 1 Phase 1.
Follow Chronic Venous Disease: new trials by email Literature Review of Chronic Venous Disease trials Research Report on Chronic Venous Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Randomized, Placebo-crontrolled Clinical Trial Evaluating the Efficacy and Safety of Heparan Sulfate 120 mg Prolonged-Release Tablets Compared With Placebo in Patients With Chronic Venous Disease CLR Tablets - Heparan Sulphate, CLR Placebo - Chronic Venous Disease, Vein Disease | Phase 3 | Not yet recruiting | Barbara Maglione | 174 | 2026-11-01 | 2026-07-06 |
| The ReCAna for Lower ExtremIty Venous OBstructions and In-StEnt Restenosis Registry Recanalization and debulking - Chronic Venous Disease, Chronic Venous Insufficiency, CVI | Not yet recruiting | Intervene, Inc. | 500 | 2026-10-01 | 2026-10-23 | |
| Foam Sclerotherapy With or Without Transdermal Laser for Reticular Veins and Telangiectasias Polidocanol foam sclerotherapy, Transdermal 1064 nm Nd:YAG Laser - Telangiectasias, Reticular Veins | Phase 4 | Recruiting | University of Sao Paulo | 70 | 2026-09-01 | 2026-10-05 |
| Effect of Photobiomodulation on Healing of Venous Leg Ulcers Photobiomodulation Therapy, Sham Photobiomodulation, Compression Therapy - Venous Leg Ulcer (VLU), Venous Hypertension Ulcers | Not applicable | Recruiting | University of Nove de Julho | 102 | 2026-08-03 | 2026-09-09 |
| Ruscus Evaluation for Symptom Control in Uncomplicated Chronic Venous Insufficiency Chronic Venous Disease | Recruiting | Turkish Society for Vascular and Endovascular Surgery | 564 | 2026-06-02 | 2026-07-31 | |
| Evaluation of Lymphatic Response to Physiotherapy in Patients With Swelling Associated With Superficial Venous Disease Indocyanine Green near infrared fluorescence imaging, advanced pneumatic compression, Duplex ultrasound - Chronic Venous Disease | Phase 1 / Phase 2 | Enrolling by invitation | The University of Texas Health Science Center, Houston | 34 | 2025-09-01 | 2025-09-16 |
| The Feasibility, Efficacy and Safety of UZit®: Single-arm Clinical Trial in Patients With Symptomatic Chronic Venous Disease UZit® - Venous Insufficiency of Leg, Drainage | Not applicable | Completed | Universidade do Porto | 17 | 2025-04-01 | 2025-12-10 |
| Mobile Phone Thermal Imaging Assessment of Incompetent Perforator Veins Mobile phone thermal imaging - Chronic Venous Disease | Not applicable | Not yet recruiting | Guangdong Second Provincial General Hospital | 100 | 2025-03-01 | 2025-02-19 |
| Brazilian Registry of Chronic Venous Disease - Risk Factors, Comorbidities, Clinical and Surgical Treatment Chronic Venous Disease | Completed | Vinícius C Quintão, MD, MSc, PhD | 650 | 2024-10-18 | 2026-01-20 | |
| Outcomes of Different Treatment Options in Chronic Venous Disease Radiofrequency ablation using Closure fast, Aethoxysclerol, Daflon - Chronic Venous Disease | Not yet recruiting | Universitaire Ziekenhuizen KU Leuven | 2000 | 2024-07-01 | 2024-06-28 | |
| Evaluation of the AIVARIX in Detecting Signs C 1-2 Classes of CVD to estimate Sensitivity and Specificity AIVARIX app in detecting C1 and C2 classes of CVD - Chronic Venous Disease, CVD | Completed | Servier Russia | 433 | 2022-12-01 | 2024-09-25 | |
| Sulodexide in the Treatment of Chronic Primary Venous Disease of the Lower Extremities Vessel, Placebo - Chronic Venous Disease, Chronic Insufficiency Venous | Phase 3 | Unknown | Value Outcomes Ltd. | 290 | 2021-11-25 | 2023-06-22 |
| VEIN Health - CVD Prevalence and Characteristics No intervention provided - Chronic Venous Disease | Unknown | Bokhua Memorial Cardiovascular Center | 10000 | 2021-05-01 | 2021-05-26 | |
| Phase 4 Study to Evaluate Efficacy and Safety of Entelon Tab.150mg in Patients With Chronic Venous Disease(CVD) Entelon Tab.150mg, Venitol Tab., Placebo of Venitol Tab. - Chronic Venous Disease | Phase 4 | Unknown | Hanlim Pharm. Co., Ltd. | 278 | 2021-01-28 | 2021-05-11 |
| Effectiveness of a Nursing Intervention Program for Patients Undergoing Ultrasound-Guided Foam Sclerotherapy Structured Nursing Intervention Program - Chronic Venous Disease | Not applicable | Completed | Hospital Universitari Vall d'Hebron Research Institute | 79 | 2020-10-09 | 2026-08-26 |
| Chronic VEnous dIsorders maNagement and Treatment effectivenesS evaluaTion in Chronic vEnous Disease, an International Program Chronic Venous Disease | Completed | Servier Affaires Médicales | 6419 | 2020-06-15 | 2023-10-06 | |
| Clinical Trial to Assess the Efficacy of µSmin® Plus µSmin® Plus, Placebo - Chronic Venous Disease | Not applicable | Completed | Giellepi S.p.A | 73 | 2019-11-15 | 2020-06-25 |
| Effects of Local Insulin on Varicose Ulcers for Wound Healing Insulin Glargine, Saline - Chronic Venous Disease, Varicose Ulcer | Phase 3 | Completed | Hospital Central "Dr. Ignacio Morones Prieto" | 13 | 2019-06-01 | 2020-03-17 |
| Evaluation of the Efficacy and Tolerability of Detralex in Patients With Chronic Venous Edema in Real Clinical Practice Chronic Venous Disease | Completed | Servier Russia | 708 | 2018-12-06 | 2023-01-13 | |
| Venous Insufficiency and Neuromuscular Stimulation geko device - Chronic Venous Disease, Venous Insufficiency | Not applicable | Completed | Imperial College London | 40 | 2013-08-01 | 2019-10-25 |
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Varicose Ulcer (3) · Blindness, Cortical (1) · Edema (1) · Embolism (1) · Embolism and Thrombosis (1) · Hyperpigmentation (1) · Insulin Resistance (1) · Leg Ulcer (1) · Telangiectasis (1) · Thrombosis (1) · Venous Insufficiency (1) · Venous Thrombosis (1)
Cardiovascular Diseases (6) · Vascular Diseases (6) · Skin Diseases (4) · Skin and Connective Tissue Diseases (4) · Skin Ulcer (3) · Varicose Veins (3) · Leg Ulcer (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Blindness (1) · Eye Diseases (1) · Glucose Metabolism Disorders (1) · Hyperinsulinism (1) · Metabolic Diseases (1) · Nervous System Diseases (1)
Compression Bandages (2) · Polidocanol (2) · Administration, Cutaneous (1) · Antistax (1) · Diosmin (1) · Heparitin Sulfate (1) · Insulin Glargine (1) · Low-Level Light Therapy (1) · S 5682 (1) · Sodium Chloride (1) · Stockings, Compression (1) · Ultrasonography, Doppler, Duplex (1) · troxerutin (1)
Servier Russia (2) · BSN Medical Inc (1) · Barbara Maglione (1) · Bokhua Memorial Cardiovascular Center (1) · Giellepi S.p.A (1) · Guangdong Second Provincial General Hospital (1) · Hanlim Pharm. Co., Ltd. (1) · Hospital Central "Dr. Ignacio Morones Prieto" (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · Imperial College London (1) · Intervene, Inc. (1) · Professor Stewart Walsh (1) · Servier Affaires Médicales (1) · The University of Texas Health Science Center, Houston (1) · Turkish Society for Vascular and Endovascular Surgery (1)
Brazil (3) · United States (3) · Russia (2) · Czechia (1) · France (1) · Ireland (1) · Mexico (1) · Portugal (1) · Romania (1) · South Korea (1) · Spain (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Alun Davies (1) · Doina Rosu, MD (1) · John C Rasmussen, PhD (1) · Jose L Ramirez-GarciaLuna, MD, PhD (1) · Joseph Raffetto, MD (1) · Kush R Desai, MD (1) · Mamuka Bokuchava, MD, PhD (1) · Nevzate Erdil, MD (1) · Nugzar Pargalava, MD, PhD (1) · Pierce A Grace, MCh FRCSI (1) · Rodrigo Kikuchi, MD, PhD (1) · Sameh Sayfo, MD, MBA (1)
PMID 10842165, PMID 18178472, PMID 24119467, PMID 24281606, PMID 29845043, PMID 34528591, PMID 34859549, PMID 34880620, PMID 34942339, PMID 35932720, PMID 36449789, PMID 37003361, PMID 3721683, PMID 37314059, PMID 37728696, PMID 9933194