5 completed, 2 terminated, 1 active not recruiting, 1 recruiting. 5 Phase 2, 3 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Terminated 1, Unknown 1 |
| Phase 1 | 3 | Active not recruiting 1, Completed 1, Unknown 1 |
| Not applicable | 1 | Completed 1 |
Follow Central Nervous System Tumor, Pediatric: new trials by email Literature Review of Central Nervous System Tumor, Pediatric trials Research Report on Central Nervous System Tumor, Pediatric
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China Medulloblastoma, Central Nervous System Tumor, Pediatric | Recruiting | Beijing Tiantan Hospital | 400 | 2023-01-01 | 2023-01-05 | |
| EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors EGFR806-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Completed | Seattle Children's Hospital | 11 | 2019-03-19 | 2025-12-17 |
| HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors HER2-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Active not recruiting | Seattle Children's Hospital | 10 | 2018-07-26 | 2025-12-17 |
| The Use of 5-aminolevulinic Acid (ALA) as an Intraoperative Tumor Marker for Resection of Pediatric Central Nervous System (CNS) Tumors 5ALA - Central Nervous System Tumor, Pediatric | Phase 1 / Phase 2 | Unknown | Tel-Aviv Sourasky Medical Center | 100 | 2014-02-01 | 2014-01-30 |
| Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Real Acupressure Band, Placebo Acupressure Band - Central Nervous System Tumor, Pediatric, Chemotherapy-induced Nausea and Vomiting | Not applicable | Completed | University of South Florida | 187 | 2011-05-01 | 2021-08-18 |
| Methylphenidate HCl or Modafinil in Treating Young Patients With Excessive Daytime Sleepiness After Cancer Therapy methylphenidate hydrochloride, modafinil, placebo - Central Nervous System Tumor, Pediatric, Fatigue | Phase 2 | Terminated | University of South Florida | 1 | 2010-07-01 | 2014-02-21 |
| Etoposide, Cyclophosphamide, Thalidomide, Celecoxib, and Fenofibrate in Relapsed or Progressive Cancer celecoxib, cyclophosphamide, etoposide - Central Nervous System Tumor, Pediatric, Leukemia | Phase 2 | Completed | Dana-Farber Cancer Institute | 101 | 2005-01-01 | 2014-10-01 |
| Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT filgrastim, cisplatin, cyclophosphamide - Central Nervous System Tumor, Pediatric | Phase 2 | Completed | Dana-Farber Cancer Institute | 25 | 2003-02-01 | 2015-12-24 |
| Thalidomide and Temozolomide in Relapsed or Progressive CNS Disease or Neuroblastoma temozolomide, thalidomide - Central Nervous System Tumor, Pediatric, Neuroblastoma | Phase 2 | Completed | Dana-Farber Cancer Institute | 15 | 2002-09-01 | 2014-10-07 |
| Genetic Study of Brain Tumors in Young Children Central Nervous System Tumor, Pediatric | Terminated | Pediatric Brain Tumor Consortium | 38 | 2001-03-01 | 2011-07-20 |
Central Nervous System Neoplasms (10) · Brain Neoplasms (4) · Rhabdoid Tumor (4) · Ependymoma (3) · Glioma (3) · Medulloblastoma (3) · Neoplasms, Germ Cell and Embryonal (3) · Choroid Plexus Carcinoma (2) · Choroid Plexus Neoplasms (2) · Neuroblastoma (2) · Neuroectodermal Tumors, Primitive (2) · Pinealoma (2) · Astrocytoma (1) · Fatigue (1) · Leukemia (1)
Neoplasms (10) · Neoplasms by Site (10) · Nervous System Diseases (10) · Nervous System Neoplasms (10) · Neoplasms by Histologic Type (8) · Brain Diseases (6) · Central Nervous System Diseases (6) · Neoplasms, Glandular and Epithelial (6) · Neoplasms, Nerve Tissue (6) · Neoplasms, Neuroepithelial (6) · Neuroectodermal Tumors (6) · Neoplasms, Complex and Mixed (4) · Neoplasms, Germ Cell and Embryonal (3) · Neuroectodermal Tumors, Primitive (3) · Brain Neoplasms (2)
Automobiles (2) · Cyclophosphamide (2) · Etoposide (2) · Temozolomide (2) · Thalidomide (2) · Celecoxib (1) · Cisplatin (1) · Cytarabine (1) · Dactinomycin (1) · Dexrazoxane (1) · Doxorubicin (1) · Fenofibrate (1) · Filgrastim (1) · Granulocyte Colony-Stimulating Factor (1) · Hydrocortisone (1)
Dana-Farber Cancer Institute (3) · Seattle Children's Hospital (2) · University of South Florida (2) · Beijing Tiantan Hospital (1) · Pediatric Brain Tumor Consortium (1) · Tel-Aviv Sourasky Medical Center (1)
United States (7) · Canada (1) · China (1) · Israel (1)
Mark W. Kieran, MD, PhD (3) · Gerald Rosen, MD (1) · Jaclyn A. Biegel, PhD (1) · Juliane Gust, MD, PhD (1) · Lee Dupuis, PhD (1) · Rebecca Ronsley, MD (1) · Tao Jiang, MD (1) · Thomas Williams McLean, MD (1) · Tom Geller, MD (1)
PMID 11807556, PMID 19064966, PMID 34253928, PMID 37640679
P30CA006516 (3), U10CA081920 (2)