18 completed, 9 unknown, 5 recruiting, 4 terminated. 8 Not applicable, 7 Phase 3, 4 Phase 2, 2 Phase 1, 2 Phase 4.
Follow Cardiac Toxicity: new trials by email Literature Review of Cardiac Toxicity trials Research Report on Cardiac Toxicity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cardiovascular Health in Adult Patients With Cancer Exposed to Cardiotoxic Therapies ECHOCARDIOGRAPHY, ELECTROCARDIOGRAPHY (ECG), LABORATORY TESTS - Cardiac Toxicity, Cancer | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 300 | 2025-02-28 | 2025-03-04 | |
| Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM) Sacubitril-valsartan, Placebo - Breast Cancer, Neoplasm, Breast | Phase 4 | Recruiting | Silesian Centre for Heart Diseases | 600 | 2024-04-17 | 2025-03-14 |
| The STOP-MED CTRCD Trial Stopping Heart Failure Medication(s) - Heart Failure, Cardiotoxicity | Phase 4 | Recruiting | Dinesh Thavendiranathan | 335 | 2024-03-04 | 2026-07-07 |
| Translating ECHOS2 Into an mHealth Platform Computerized Intervention Authoring Software (CIAS) - Childhood Cancer, Cardiac Toxicity | Not applicable | Completed | Washington University School of Medicine | 73 | 2023-07-05 | 2024-01-11 |
| Cardiovascular Effects of Intrathecal Hyperbaric Prilocaine or Bupivacaine in Surgery Under Spinal Anesthesia Hyperbaric bupivacaïne, Hyperbaric prilocaïne - Spinal Anesthesia, Cardiac Toxicity | Not applicable | Unknown | Centre Hospitalier Universitaire Saint Pierre | 60 | 2023-03-22 | 2023-03-24 |
| Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted Lipitor 40mg Tablet - Cardiac Toxicity, Early-stage Breast Cancer | Phase 2 | Recruiting | Rutgers, The State University of New Jersey | 60 | 2022-09-19 | 2025-11-14 |
| Cardiotoxicity of Targeted Therapy for HER-2 Positive Breast Cancer Patients at High Altitude High altitude - HER2-positive Breast Cancer, Targeted Therapy | Unknown | Affiliated Hospital of Qinghai University | 132 | 2021-10-01 | 2021-10-01 | |
| Evaluation of Impedance Cardiography for Assessing Hemodynamic Shifts in Patients With LA-NSCLC During Treatment. Impedance cardiography - Non-small Cell Lung Cancer, Cardiac Toxicity | Active not recruiting | Sun Yat-sen University | 231 | 2021-06-05 | 2026-03-11 | |
| Radiation-induced Cardiac Toxicity After Non-small Cell Lung Cancer Radiotherapy Echocardiography - Non-small Cell Lung Cancer, Radiation Toxicity | Unknown | Military Institute od Medicine National Research Institute | 100 | 2021-05-01 | 2021-07-23 | |
| Risk Assessment Model of Trastuzumab-related Cardiotoxicity in Breast Cancer Patients Trastuzumab - Cardiac Toxicity, Antitumor Drugs | Unknown | Peking University Third Hospital | 240 | 2021-01-08 | 2021-07-15 | |
| Exercise Response After Revalidation in Cancer Patients Cardiorespiratory exercise test - Oncology, Cardiac Toxicity | Not applicable | Unknown | Universitair Ziekenhuis Brussel | 191 | 2020-08-01 | 2020-07-08 |
| Effects of Anti-VEGF Targeted Drugs on Patients' Blood Pressure and Endothelial Function Anti-VEGF - Cardiac Toxicity, VEGF | Unknown | Peking University Third Hospital | 30 | 2019-07-05 | 2021-07-15 | |
| Association Between Telomere Length and Cardiac Dysfunction Relative telomere length - Cardiac Toxicity, Acute Leukemia | Completed | Air Force Military Medical University, China | 300 | 2019-01-01 | 2020-06-01 | |
| The CAROLE (CArdiac Related Oncologic Late Effects) Study Coronary Artery Disease, Cardiac Disease | Completed | Northwell Health | 201 | 2017-06-27 | 2019-05-21 | |
| BreAst Cancer and Cardiotoxicity Induced by RAdioTherapy: the BACCARAT Study Subclinical cardiac lesions and biomarkers - Breast Cancer, Cardiac Toxicity | Not applicable | Completed | Sophie JACOB | 118 | 2015-10-01 | 2023-11-08 |
| COr Loco-regional Advanced Lung Cancer Treated With Chemo-radiotherapy (COLA) Chemoradiotherapy - Cardiac Toxicity, Lung Cancer Stage III | Recruiting | Odense University Hospital | 100 | 2015-08-01 | 2023-12-06 | |
| Race Difference Moxifloxacin-induced QT Prolongation Between Healthy Chinese and Caucasian Volunteers Moxifloxacin - Cardiac Toxicity | Phase 1 | Unknown | Haiyan Li | 80 | 2014-04-01 | 2014-04-21 |
| MRI in Detecting Heart Damage in Patients With Cancer Receiving Chemotherapy With Exercise Capacity Addendum Magnetic resonance imaging, Physical Activity, Healthy Living - Cardiac Toxicity, Malignant Neoplasm | Not applicable | Completed | Wake Forest University Health Sciences | 28 | 2013-01-01 | 2023-05-19 |
| Effectiveness of Using Biomarkers to Detect and Identify Cardiotoxicity and Describe Treatment (PREDICT) Laboratory Biomarker Analysis, Questionnaires - Cardiac Toxicity, Unspecified Adult Solid Tumor, Protocol Specific | Not applicable | Unknown | M.D. Anderson Cancer Center | 597 | 2011-01-25 | 2019-05-21 |
| Early Detection of Anthracycline Cardiotoxicity by Echocardiographic Analysis of Myocardial Deformation in 2D Strain Echographic analysis of myocardial deformation in 2D strain - Leukemia, Cardiac Toxicity | Not applicable | Completed | University Hospital, Bordeaux | 100 | 2010-09-28 | 2026-05-28 |
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Cardiotoxicity (37) · Breast Neoplasms (13) · Neoplasms (7) · Lymphoma (5) · Breast Neoplasms, Male (3) · Carcinoma, Non-Small-Cell Lung (2) · Heart Diseases (2) · Heart Failure (2) · Inflammatory Breast Neoplasms (2) · Leukemia (2) · Lung Neoplasms (2) · Radiation Injuries (2) · Sarcoma (2) · Altitude Sickness (1) · Breast Diseases (1)
Cardiovascular Diseases (37) · Chemically-Induced Disorders (37) · Drug-Related Side Effects and Adverse Reactions (37) · Pathologic Processes (37) · Pathological Conditions, Signs and Symptoms (37) · Wounds and Injuries (37) · Heart Diseases (35) · Radiation Injuries (35) · Neoplasms (21) · Neoplasms by Site (16) · Skin Diseases (13) · Skin and Connective Tissue Diseases (13) · Breast Diseases (12) · Neoplasms by Histologic Type (9) · Hemic and Lymphatic Diseases (6)
Doxorubicin (9) · Dexrazoxane (7) · Razoxane (6) · Cyclophosphamide (5) · Trastuzumab (5) · Filgrastim (4) · Echocardiography (3) · Etoposide (3) · Granulocyte Colony-Stimulating Factor (3) · Methotrexate (3) · Radiotherapy (3) · Vincristine (3) · Bleomycin (2) · Chemotherapy, Adjuvant (2) · Cisplatin (2)
Children's Oncology Group (5) · National Cancer Institute (NCI) (3) · Peking University Third Hospital (2) · Wake Forest University Health Sciences (2) · AHS Cancer Control Alberta (1) · Affiliated Hospital of Qinghai University (1) · Air Force Military Medical University, China (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Cancer Trials Ireland (1) · Centre Hospitalier Universitaire Saint Pierre (1) · Dinesh Thavendiranathan (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Haiyan Li (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1)
United States (20) · Canada (6) · China (6) · Australia (3) · Poland (3) · Switzerland (3) · Belgium (2) · France (2) · United Kingdom (2) · Denmark (1) · Ireland (1) · Italy (1) · Netherlands (1) · Puerto Rico (1) · Spain (1)
Cindy Schwartz, MD (2) · Antonella Lombardo (1) · Atul Pathak, MD PhD (1) · Barbara L. Asselin, MD (1) · Bassam Abdulkarim, MD (1) · Bernard Cosyns, Professor (1) · Cameron K. Tebbi, MD (1) · Carrie G Lenneman, MD, MSCI (1) · Daniel Lenihan, MD (1) · Donald W. Northfeld, MD (1) · Douglas B Sawyer, MD, PhD (1) · Edith A. Perez, MD (1) · Erika Waters, PhD, MPH (1) · Gretchen Wells, MD, PhD (1) · Haiyan Li, MD (1)
PMID 19584400, PMID 22689804, PMID 22911615, PMID 23273589, PMID 25114718, PMID 25975632, PMID 27056179, PMID 28123764, PMID 28459938, PMID 28525534, PMID 30732640, PMID 31171092, PMID 31727075, PMID 32154021, PMID 32819449, PMID 37449716, PMID 37504555, PMID 38634292, PMID 38845066, PMID 39187877, PMID 39810280, PMID 41877348
P30CA012197 (1), P30CA015083 (1), P30CA036727 (1), P30CA068485 (1), R01CA167821 (1), R21CA226960 (1), U01CA097452 (1), U10CA030969 (1), U10CA031946 (1), U10CA032102 (1), U10CA081920 (1)