9 completed. 9 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 9 |
| Phase 2 | 1 | Completed 1 |
Follow Cardiac Output, Low: new trials by email Literature Review of Cardiac Output, Low trials Research Report on Cardiac Output, Low
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nitric Oxide During Bypass for Arterial Switch Operation Nitric Oxide - Low Cardiac Output Syndrome, Transposition of Great Vessels | Phase 3 | Completed | Murdoch Childrens Research Institute | 300 | 2018-07-11 | 2024-04-18 |
| Liberal Versus Restrictive Use of Dobutamine in Cardiac Surgery Liberal dobutamine protocol, Restrictive dobutamine protocol - Cardiac Output, Low, Coronary Disease | Phase 3 | Completed | University of Sao Paulo | 160 | 2015-02-01 | 2022-03-16 |
| Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass Levosimendan, Placebo - Coronary Artery Bypass Grafting, Mitral Valve Surgery | Phase 3 | Completed | Tenax Therapeutics, Inc. | 882 | 2014-07-01 | 2018-06-21 |
| Preoperative Levosimendan in CABG Patients With Poor LV Function levosimendan, Placebo - Coronary Artery Bypass Grafting, Left Ventricular Dysfonction | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 335 | 2013-06-01 | 2016-02-25 |
| Remote Ischemic Preconditioning in High Risk Cardiovascular Surgery Patients Remote ischemic preconditioning stimulus, control - Death, Stroke | Phase 3 | Completed | Queen's University | 429 | 2012-02-01 | 2016-02-05 |
| Metabolic Support With Perhexiline to Protect Myocardium Undergoing Coronary Artery Surgery Perhexiline, Placebo marked PEXSIG - Myocardial Reperfusion Injury, Cardiac Output, Low | Phase 2 / Phase 3 | Completed | University Hospital Birmingham | 290 | 2007-02-01 | 2010-05-20 |
| The Efficacy of Hypertonic Lactate Solution in CABG(Coronary Artery Bypass Grafting) Patients Hypertonic lactate, Ringer's lactate - Low Cardiac Output | Phase 3 | Completed | Innogene Kalbiotech Pte. Ltd | 66 | 2005-07-01 | 2007-09-14 |
| The Effects of Adrenaline and Milrinone in Patients With Myocardial Dysfunction After CABG adrenaline, milrinone - Cardiac Output, Low | Phase 3 | Completed | University of Luebeck | 60 | 2003-06-01 | 2015-06-03 |
| Efficacy, Safety of Hypertonic Lactate Soln. as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG Pats Hypertonic lactate, Ringer's lactate - Low Cardiac Output | Phase 3 | Completed | Innogene Kalbiotech Pte. Ltd | 230 | 2002-03-01 | 2007-09-14 |
Renal Insufficiency (2) · Coronary Disease (1) · Death (1) · Heart Defects, Congenital (1) · Myocardial Infarction (1) · Myocardial Reperfusion Injury (1) · Stroke (1) · Transposition of Great Vessels (1) · Ventricular Dysfunction, Left (1)
Cardiovascular Diseases (9) · Heart Diseases (9) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (9) · Myocardial Ischemia (3) · Vascular Diseases (3) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Kidney Diseases (2) · Male Urogenital Diseases (2) · Pathologic Processes (2) · Urogenital Diseases (2) · Urologic Diseases (2) · Brain Diseases (1) · Cardiomyopathies (1)
Ringer's Lactate (2) · Simendan (2) · Epinephrine (1) · Milrinone (1) · Nitric Oxide (1) · Perhexiline (1) · Riboflavin (1)
Innogene Kalbiotech Pte. Ltd (2) · Assistance Publique - Hôpitaux de Paris (1) · Murdoch Childrens Research Institute (1) · Queen's University (1) · Tenax Therapeutics, Inc. (1) · University Hospital Birmingham (1) · University of Luebeck (1) · University of Sao Paulo (1)
Canada (3) · Indonesia (3) · Australia (1) · Brazil (1) · France (1) · Malaysia (1) · United Kingdom (1) · United States (1)
Xavier Leverve, MD, PhD (2) · Bernard Cholley, MD, PhD (1) · Darrin Payne, MD (1) · Domeinco Pagano, MD FRCS (1) · Iqbal Mustafa, MD (1) · John Alexander, MD (1) · Matthias Heringlake, MD (1) · Rajendra Mehta, MD (1) · Thibaut Caruba, PharmD (1) · Warwick Butt (1)
PMID 17470271, PMID 23228403, PMID 24948413, PMID 25734940, PMID 25989324, PMID 27496105, PMID 27686343, PMID 27914501, PMID 28316276, PMID 28787507, PMID 33496877, PMID 35263653