9 completed, 4 recruiting, 2 terminated, 2 unknown. 18 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Completed 9, Recruiting 4, Terminated 2, Unknown 2, Not yet recruiting 1 |
| Phase 1 | 3 | Recruiting 2, Not yet recruiting 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
Follow Cancer Cachexia: new trials by email Literature Review of Cancer Cachexia trials Research Report on Cancer Cachexia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The First in Human Study of QLS2319 in Healthy Subjects and Cancer Cachexia QLS2319, Placebo - Cancer Cachexia, Cancer Cachexia Syndrome | Phase 1 / Phase 2 | Recruiting | Qilu Pharmaceutical Co., Ltd. | 88 | 2026-09-16 | 2026-09-25 |
| An Phase I/IIa Clinical Study to Evaluate the Safety/Tolerability, Pharmacokinetics and Preliminary Efficacy of INB301 Injection in Patients With Cancer Cachexia INB301 Injection - Cancer Cachexia | Phase 1 / Phase 2 | Not yet recruiting | Yunnan Baiyao Group Co., Ltd. | 146 | 2026-05-01 | 2026-05-13 |
| Psilocybin-Assisted Psychotherapy in Cancer Patients With Adjustment Disorder Psilocybin therapy - Adjustment Disorder, Adjustment Disorder With Anxious Mood | Phase 2 | Recruiting | Psyence Australia Pty Ltd | 87 | 2025-10-01 | 2026-10-29 |
| An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia. NGM120 Q4W, NGM120 Q8W, Placebo given - Colorectal Cancer, CRC (Colorectal Cancer) | Phase 2 | Recruiting | NGM Biopharmaceuticals, Inc | 136 | 2025-06-25 | 2026-04-01 |
| A Study of JMT203 in Patients With Cancer Cachexia JMT203 Injection - Non Small Cell Lung Cancer, Pancreatic Cancer | Phase 1 / Phase 2 | Recruiting | Shanghai JMT-Bio Inc. | 307 | 2024-05-15 | 2026-05-22 |
| The Effect of Curcumin for Treatment of Cancer Anorexia-Cachexia Syndrome in Patients With Stage III-IV of Head and Neck Cancer Curcumin, Placebo - Cancer Cachexia, Head and Neck Cancer | Phase 2 | Completed | Phramongkutklao College of Medicine and Hospital | 20 | 2020-02-13 | 2023-03-28 |
| The Safety and Effect Study of Acupuncture for Anorexia in Patients With Gastrointestinal Tract and Lung Cancers Acupuncture, Sham Acupuncture, Megestrol Acetate - Anorexia, Cancer Cachexia | Phase 2 / Phase 3 | Unknown | Xinqiao Hospital of Chongqing | 160 | 2015-12-01 | 2015-12-04 |
| Study of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases. Ruxolitinib - Cancer Cachexia | Phase 2 | Terminated | Kantonsspital Aarau | 8 | 2014-04-20 | 2019-02-28 |
| The Role of Ghrelin in Cancer Cachexia Anamorelin HCl, Placebo - Cancer Cachexia | Phase 2 | Terminated | VA Office of Research and Development | 10 | 2012-06-01 | 2018-07-17 |
| Pilot Clinical Trial of Repeated Doses of Macimorelin to Assess Safety and Efficacy in Patients With Cancer Cachexia Macimorelin, Placebo - Cancer Cachexia | Phase 2 | Completed | Garcia, Jose M., MD, PhD | 15 | 2012-05-01 | 2024-03-20 |
| Effect of Omega-3 Supplements on the Prevention of Cachexia in Head and Neck Cancer Treated With Radio(Chemo)Therapy BioMega SDA®, Sunflower oil high oleic - Cancer Cachexia, Head and Neck Cancer | Phase 2 / Phase 3 | Completed | General Hospital Groeninge | 91 | 2012-04-01 | 2015-03-10 |
| A Clinical Study With MT-102 in Subjects With Cancer Cachexia MT-102 - Cancer Cachexia | Phase 2 | Completed | Akamis Bio | 87 | 2011-04-01 | 2014-09-10 |
| Open Label Study With OHR/AVR118 in Advanced Cancer Patients With Anorexia-Cachexia OHR/AVR118 - Anorexia, Cancer Cachexia | Phase 2 | Unknown | Ohr Pharmaceutical Inc. | 20 | 2010-09-01 | 2012-11-27 |
| Placebo Controlled, Randomized Safety and Efficacy Study of RC-1291 in Cancer Anorexia/Cachexia RC-1291, placebo - Cancer Cachexia | Phase 2 | Completed | Helsinn Therapeutics (U.S.), Inc | 51 | 2006-09-01 | 2013-09-02 |
| Placebo Controlled, Randomized Safety and Efficacy Study of RC-1291 in Cancer Anorexia/Cachexia. RC-1291 HCl, Placebo - Cancer Cachexia | Phase 2 | Completed | Helsinn Therapeutics (U.S.), Inc | 2005-11-01 | 2013-09-02 | |
| Safety and Efficacy of RC-1291 HCl in Patients With Cancer Related Anorexia and Weight Loss RC-1291 HCl - Cancer Cachexia | Phase 2 | Completed | Helsinn Therapeutics (U.S.), Inc | 80 | 2005-06-01 | 2013-09-02 |
| A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss Fish oil supplement - Cancer, Cancer Cachexia | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 25 | 2004-06-01 | 2019-01-18 |
| Parenteral Nutrition Support for Patients With Pancreatic Cancer parenteral nutrition - Cancer Cachexia, Pancreatic Cancer | Phase 2 | Completed | CONKO-Studiengruppe | 32 | 2002-01-01 | 2009-06-12 |
Anorexia (3) · Cachexia (3) · Neoplasms (3) · Pancreatic Neoplasms (3) · Weight Loss (3) · Head and Neck Neoplasms (2) · Adjustment Disorders (1) · Arthritis, Rheumatoid (1) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Colorectal Neoplasms (1) · Endometrial Neoplasms (1) · Fatigue (1) · Hyperphagia (1) · Kidney Neoplasms (1)
Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8) · Body Weight (6) · Body Weight Changes (6) · Neoplasms by Site (6) · Neoplasms (5) · Digestive System Diseases (4) · Digestive System Neoplasms (4) · Signs and Symptoms, Digestive (4) · Endocrine Gland Neoplasms (3) · Endocrine System Diseases (3) · Pancreatic Diseases (3) · Thinness (3) · Weight Loss (3) · Gastrointestinal Diseases (2)
Acupuncture Therapy (1) · Curcumin (1) · EOM613 (1) · Megestrol Acetate (1) · Parenteral Nutrition (1) · RC-1291 (1) · macimorelin (1) · ruxolitinib (1)
Helsinn Therapeutics (U.S.), Inc (3) · Akamis Bio (1) · CONKO-Studiengruppe (1) · Garcia, Jose M., MD, PhD (1) · General Hospital Groeninge (1) · Kantonsspital Aarau (1) · NGM Biopharmaceuticals, Inc (1) · Ohr Pharmaceutical Inc. (1) · Phramongkutklao College of Medicine and Hospital (1) · Psyence Australia Pty Ltd (1) · Qilu Pharmaceutical Co., Ltd. (1) · Shanghai JMT-Bio Inc. (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · VA Office of Research and Development (1) · Xinqiao Hospital of Chongqing (1)
United States (7) · China (4) · Germany (2) · Australia (1) · Belgium (1) · Canada (1) · Georgia (1) · India (1) · Malaysia (1) · South Korea (1) · Switzerland (1) · Taiwan (1) · Thailand (1)
William Polvino, MD (3) · Adrian S. Dobs, MD, MHS (1) · Chaoting Zhao, MD (1) · Haiou Luo, PhD (1) · Jose M Garcia, MD, PhD (1) · Jose M. Garcia, MD PhD (1) · Mario Bargetzi, MD (1) · Martin Chasen, MBChB (1) · Nathan Cantoni, MD (1) · Neil Maresky (1) · Philip R Debruyne, MD PhD (1) · Tawasapon Thambamroong, MD (1) · Tom Boterberg, MD PhD (1)
PMID 25524795, PMID 10444409, PMID 11323096, PMID 11712783, PMID 12676044, PMID 17509812, PMID 17942826, PMID 18628464, PMID 19393114, PMID 20214798, PMID 21296615, PMID 21565893, PMID 21810420, PMID 23530101, PMID 24614693, PMID 24648302, PMID 25293388, PMID 27888116, PMID 29575771, PMID 2988769, PMID 35694030, PMID 36860137, PMID 7424938
P50AT000437 (1)