81 completed, 11 unknown, 6 recruiting, 5 not yet recruiting. 89 Not applicable, 5 Phase 4, 3 Phase 2, 2 Early Phase 1, 2 Phase 1.
Follow Caffeine: new trials by email Literature Review of Caffeine trials Research Report on Caffeine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effects of a Caffeine Supplement (UBrain) on Cognitive Fatigue After a Virtual Reality Drive Simulation Caffeine supplement, Placebo - Caffeine | Not applicable | Not yet recruiting | University of Padova | 8 | 2026-10-01 | 2026-10-05 |
| Effects of Caffeine on Chess Performance and Cognitive Function in Professional Chess Players Caffeinated Coffee, Decaffeinated Coffee Placebo - Cognitive Performance, Attention | Not applicable | Recruiting | St. Louis University | 12 | 2026-08-25 | 2026-09-30 |
| CHECK-NIRS2D-Study NIRS, Tissue Oxygenation | Recruiting | Heinrich-Heine University, Duesseldorf | 20 | 2026-07-28 | 2026-10-02 | |
| Investigating the Effect of Caffeine and Alcohol on Pupil Dynamics Placebo Comparator: Placebo, Caffeine administration, Alcohol (Ethanol) - Caffeine, Alcohol | Not applicable | Recruiting | National University of Singapore | 100 | 2026-06-01 | 2026-06-04 |
| Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia Caffine citrate, Placebo - Sublingual, Caffeine | Not applicable | Recruiting | Cairo University | 50 | 2026-04-18 | 2026-04-21 |
| Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory Support Caffeine, Placebo - Preterm Birth, Caffeine | Phase 2 | Not yet recruiting | Queen's University | 62 | 2026-04-01 | 2026-03-10 |
| Caffeine and Wrestling Performance in Male Wrestlers of Different Weight Classes: A Randomized Crossover Trial Caffeine - Athletic Performance, Caffeine | Not applicable | Completed | Islamic Azad University, Abadan Branch | 95 | 2026-03-30 | 2026-10-22 |
| Caffeine Strategies and Fat Oxidation Caffeine (Guinama Anhydrous Powder), Caffeine (Nescafé Classic Coffee), Caffeine (Kafewake Gum) - Fat Metabolism, Caffeine | Not applicable | Enrolling by invitation | Universidad Rey Juan Carlos | 10 | 2026-03-15 | 2026-04-29 |
| Effects of Caffeine Ingestion on Morning Cognitive and 4-km Time Trial Performance in Males Caffeine (300 mg), Placebo, No Pill - Caffeine, Placebo - Control | Phase 1 / Phase 2 | Active not recruiting | Liverpool John Moores University | 15 | 2026-01-12 | 2026-03-13 |
| Effects of Variations in Caffeinated Beverages on Well-being Caffeinated, low sugar beverage, Caffeinated beverage, Control beverage - Healthy, Caffeine | Not applicable | Completed | GUAYAKI SUSTAINABLE RAINFOREST PRODUCTS, INC. | 75 | 2026-01-05 | 2026-08-06 |
| Effects of Caffeine Ingestion on Morning Cognitive and Muscle Repeated Sprint Performance in Males Caffeine, Placabo, No Pill - Caffeine, Placebo - Control | Early Phase 1 | Enrolling by invitation | Liverpool John Moores University | 15 | 2025-12-08 | 2026-03-13 |
| Effects of Caffeinated Beverages on Well-being Participants' typical caffeinated beverage, Test caffeinated beverage - Healthy, Caffeine | Not applicable | Completed | GUAYAKI SUSTAINABLE RAINFOREST PRODUCTS, INC. | 126 | 2025-11-03 | 2026-08-06 |
| The Effects of Caffeine on Exercise Physiology and Time-trial Performance in a Hot Environment Hot environment, Thermoneutral environment - Caffeine, Thermoregulation | Not applicable | Not yet recruiting | St. Mary's University, Twickenham | 15 | 2025-08-22 | 2025-08-19 |
| Oral Caffeine and Spinal-Induced Hypotension Caffeine (200 mg), Placebo - Spinal Hypotension, Caffeine | Not applicable | Completed | Cairo University | 90 | 2025-07-12 | 2025-12-18 |
| The Repeatability of the Effect of Caffeine Supplementation on Submaximal Physiological Responses and Cycling Time Trial Performance Caffeine, Placebo - Caffeine | Not applicable | Not yet recruiting | St. Mary's University, Twickenham | 12 | 2025-05-01 | 2025-04-20 |
| 5 vs 10-Minute Chewing of Caffeinated Gum: Plasma Caffeine Pharmacokinetics Caffeine 300 MG - Caffeine | Not applicable | Completed | Ege University | 30 | 2025-04-22 | 2026-02-04 |
| Effect of Low-Dose Caffeine on Performance in Elite Sitting Volleyball Players Caffeine, Placebo - Caffeine, Physical Endurance | Not applicable | Completed | Ulaç Can YILDIRIM | 13 | 2025-03-05 | 2025-07-09 |
| Investigating the Acute and Chronic Effects of a Supplement Containing Caffeine, Vitamins, Minerals and Botanical Extracts on Cognition, Sleep and Wellbeing, in Healthy Volunteers Caffeine, Vitamins, Minerals and Botanical Blend, Placebo - Caffeine, Sleep | Not applicable | Not yet recruiting | Northumbria University | 90 | 2025-02-24 | 2025-02-10 |
| Caffeine and Sport Climbing Performance Acute and moderate dose of caffeine (3 mg/kg body mass), Placebo - Climbing, Caffeine | Not applicable | Completed | University of Alcala | 13 | 2025-01-08 | 2026-05-06 |
| Caffeinated Chewing Gum on Special Forces Performance caffeine - Caffeine, Placebo | Not applicable | Completed | National Taiwan Sport University | 16 | 2024-10-05 | 2025-06-26 |
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2016 (1), 2017 (1), R01DA003890 (1), R21MH138923 (1)