7 completed, 2 recruiting, 2 withdrawn, 1 active not recruiting. 5 Phase 2, 4 Phase 1, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Active not recruiting 1, Recruiting 1 |
| Phase 1 | 4 | Completed 3, Active not recruiting 1 |
| Early Phase 1 | 1 | Withdrawn 1 |
Follow Brainstem Glioma: new trials by email Literature Review of Brainstem Glioma trials Research Report on Brainstem Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). BCB-276 - Diffuse Intrinsic Pontine Glioma, DIPG | Phase 2 | Recruiting | BrainChild Bio, Inc | 75 | 2026-09-04 | 2026-10-28 |
| Vegetative Monitoring During Brainstem-associated Surgery Intraoperative Monitoring during resection of brain tumor - Brain Tumor, Recurrent, Vestibular Schwannoma | Completed | University Hospital Tuebingen | 103 | 2018-08-28 | 2022-11-04 | |
| A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) ribociclib, Everolimus - Diffuse Intrinsic Pontine Glioma, Malignant Glioma of Brain | Phase 1 | Completed | Children's Hospital Medical Center, Cincinnati | 19 | 2017-11-14 | 2023-01-13 |
| Oncolytic Adenovirus, DNX-2401, for Naive Diffuse Intrinsic Pontine Gliomas DNX-2401 - Brainstem Glioma, Neoadjuvant Therapy | Phase 1 | Completed | Clinica Universidad de Navarra, Universidad de Navarra | 12 | 2017-05-26 | 2023-04-06 |
| Autologous Stem Cell Collection and Reinfusion in Newly Diagnosed High Grade Gliomas Radiation therapy, Temozolomide, Stem cell collection - Astrocytoma, Brainstem Glioma | Early Phase 1 | Withdrawn | Washington University School of Medicine | 2017-01-01 | 2017-02-20 | |
| A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Mebendazole, Vincristine, Carboplatin - Pilomyxoid Astrocytoma, Pilocytic Astrocytoma | Phase 1 / Phase 2 | Active not recruiting | Julie Krystal | 10 | 2013-10-22 | 2026-08-06 |
| AZD8055 for Adults With Recurrent Gliomas AZD8055 - Glioblastoma Multiforme, Anaplastic Astrocytoma | Phase 1 | Completed | National Cancer Institute (NCI) | 22 | 2011-03-04 | 2019-12-12 |
| A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children With Gliomas Ependymoma, Brainstem Glioma | Withdrawn | National Cancer Institute (NCI) | 2010-04-23 | 2019-12-12 | ||
| Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma Diffuse Intrinsic Pontine Glioma, Brainstem Glioma | Recruiting | Children's National Research Institute | 100 | 2010-04-01 | 2024-08-20 | |
| Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma Valproic acid, Bevacizumab, Radiation therapy - Glial Cell Tumors, Malignant Gliomas | Phase 2 | Completed | Baylor College of Medicine | 38 | 2009-09-01 | 2021-07-21 |
| A Study of Capecitabine (Xeloda®) and Concomitant Radiation Therapy in Children With Newly Diagnosed Brainstem Gliomas Capecitabine, Radiation therapy - Brainstem Glioma | Phase 2 | Completed | Hoffmann-La Roche | 45 | 2007-05-01 | 2014-02-06 |
| ANGIOCOMB Antiangiogenic Therapy for Pediatric Patients With Diffuse Brain Stem and Thalamic Tumors Thalidomide, etoposide, celecoxib - Brainstem Glioma | Phase 2 | Completed | Helsinki University Central Hospital | 50 | 2005-01-01 | 2014-05-08 |
Astrocytoma (6) · Glioma (6) · Brain Neoplasms (5) · Diffuse Intrinsic Pontine Glioma (5) · Glioblastoma (5) · Ependymoma (2) · Gliosarcoma (2) · Neoplasms (2) · Oligodendroglioma (2) · Optic Nerve Glioma (2) · Brain Stem Neoplasms (1) · Central Nervous System Neoplasms (1) · Neoplasms, Neuroepithelial (1) · Neuroectodermal Tumors, Primitive (1) · Neuroma, Acoustic (1)
Neoplasms by Histologic Type (9) · Neoplasms by Site (9) · Neoplasms, Germ Cell and Embryonal (9) · Neoplasms, Nerve Tissue (9) · Nervous System Diseases (9) · Nervous System Neoplasms (9) · Neuroectodermal Tumors (9) · Brain Diseases (8) · Central Nervous System Diseases (8) · Neoplasms, Glandular and Epithelial (8) · Central Nervous System Neoplasms (7) · Neoplasms (7) · Neoplasms, Neuroepithelial (7) · Infratentorial Neoplasms (6) · Brain Stem Neoplasms (5)
Radiotherapy (3) · Bevacizumab (2) · Temozolomide (2) · (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol (1) · Capecitabine (1) · Carboplatin (1) · Celecoxib (1) · Etoposide (1) · Everolimus (1) · Irinotecan (1) · Mebendazole (1) · Thalidomide (1) · Valproic Acid (1) · Vincristine (1) · ribociclib (1)
National Cancer Institute (NCI) (2) · Baylor College of Medicine (1) · BrainChild Bio, Inc (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's National Research Institute (1) · Clinica Universidad de Navarra, Universidad de Navarra (1) · Helsinki University Central Hospital (1) · Hoffmann-La Roche (1) · Julie Krystal (1) · University Hospital Tuebingen (1) · Washington University School of Medicine (1)
United States (7) · Finland (1) · Germany (1) · Spain (1)
Katherine E Warren, M.D. (2) · Cori Abikoff, MD (1) · Jack Su, MD (1) · Jaime Gallego, MD, PhD (1) · Javad Nazarian, PhD (1) · Jian Li Campian, M.D., Ph.D. (1) · Julie Krystal, MD (1) · Martin U Schuhmann, Prof (1) · Sanna-Maria Kivivuori, md (1)
PMID 17848677, PMID 18089777, PMID 22492959, PMID 24076776, PMID 24297113, PMID 24705254, PMID 24894482, PMID 24903904, PMID 27048880, PMID 31138805, PMID 32285998, PMID 35767439