58 completed, 35 recruiting, 19 terminated, 15 active not recruiting. 78 Phase 1, 51 Phase 2, 15 Not applicable, 7 Early Phase 1, 6 Phase 3.
Follow Infratentorial Neoplasms: new trials by email Literature Review of Infratentorial Neoplasms trials Research Report on Infratentorial Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| H3K27M-specific Immune Effector Cells Targeting DMG/DIPG H3K27M-EIEs - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-08-27 |
| Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG Opdualag - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 12 | 2027-03-01 | 2026-09-09 |
| Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) Tovorafenib - High Grade Glioma (HGG) of the Brain With BRAF Aberration, High Grade Glioma (III or IV) | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 79 | 2027-02-01 | 2026-10-20 |
| Immune Modulatory DC Vaccine Against Brain Tumor Immunomodulatory DC vaccine to target DIPG and GBM - Diffuse Intrinsic Pontine Glioma or Glioblastoma | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2026-12-31 | 2026-08-26 |
| IMPT Versus IMRT for Diffuse Intrinsic Pontine Glioma Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT) - Diffuse Intrinsic Pontine Gliomas (DIPG) | Phase 3 | Not yet recruiting | Shandong Cancer Hospital and Institute | 142 | 2026-12-01 | 2026-10-09 |
| Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response LSAM-Cisplatin - Diffuse Midline Glioma (DMG), Diffuse Intrinsic Pontine Glioma (DIPG) | Phase 1 / Phase 2 | Not yet recruiting | NanOlogy, LLC | 20 | 2026-12-01 | 2026-08-18 |
| IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG) Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells - High-grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 1 | Not yet recruiting | University of Florida | 24 | 2026-11-01 | 2026-09-09 |
| PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma PEP-CMV vaccine, Tetanus booster, Nivolumab - Diffuse Midline Glioma, Diffuse Midline High-grade Glioma | Phase 1 / Phase 2 | Suspended | Washington University School of Medicine | 68 | 2026-09-30 | 2026-09-11 |
| Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). BCB-276 - Diffuse Intrinsic Pontine Glioma, DIPG | Phase 2 | Recruiting | BrainChild Bio, Inc | 75 | 2026-09-04 | 2026-10-21 |
| NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors NeuroNavigation-Guided Focused Ultrasound (NgFUS), Lumason, Nivolumab - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma, High Grade Gliomas | Phase 1 | Recruiting | Children's National Research Institute | 30 | 2026-09-01 | 2026-09-09 |
| Individualized Neuro-Modulation Paired With Cerebellar Therapy Therapy - Cerebellar Ataxia, Cerebellar Diseases | Not applicable | Recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 30 | 2026-06-30 | 2026-06-11 |
| Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor Gallium maltolate - High Grade Gliomas, Atypical Teratoid Rhabdoid Tumors (ATRT) | Phase 1 | Not yet recruiting | Sarah Rumler | 15 | 2026-05-15 | 2026-01-09 |
| Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas Eflornithine (DFMO), AMXT 1501 Dicaprate - Atypical Teratoid/Rhabdoid Tumor, Embryonal Tumor With Multilayered Rosettes | Phase 1 / Phase 2 | Recruiting | Milton S. Hershey Medical Center | 265 | 2026-05-13 | 2026-09-03 |
| A Study of VRT106 in Combination With Radiotherapy in Adult Patients With Diffuse Midline Glioma / Diffuse Intrinsic Pontine Glioma VRT106 for injection - Diffuse Midline Glioma, H3 K27M-Mutant, Diffuse Intrinsic Pontine Glioma | Phase 2 | Recruiting | Guangzhou Virotech Pharmaceutical Co., Ltd. | 10 | 2026-05-07 | 2026-05-15 |
| Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation M032 - Glioma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 20 | 2026-04-23 | 2026-10-09 |
| Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery. Bupivacaine 0.25%, Dexmedetomidine 1mcg/kg, Blind greater occipital nerve block - Posterior Fossa Tumor | Phase 3 | Recruiting | Children's Cancer Hospital Egypt 57357 | 260 | 2025-12-17 | 2026-10-16 |
| Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion Lorlatinib, Lorlatinib with chemotherapy1, Lorlatinib with chemotherapy 2 - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Early Phase 1 | Recruiting | Nationwide Children's Hospital | 15 | 2025-08-03 | 2026-06-29 |
| ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas ACT001 - Diffuse Intrinsic Pontine Gliomas (DIPG), Progressive DIPG | Phase 2 | Recruiting | Nationwide Children's Hospital | 60 | 2025-07-10 | 2026-09-21 |
| Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age SIACI of cetuximab and bevacizumab - Glioblastoma Multiforme, Anaplastic Astrocytoma | Phase 1 / Phase 2 | Recruiting | University of Miami | 20 | 2025-06-19 | 2025-12-08 |
| Atovaquone Combined With Radiation in Children With Malignant Brain Tumors Atovaquone, Radiation Therapy - High-grade Glioma, Medulloblastoma | Phase 1 | Recruiting | Emory University | 18 | 2025-03-28 | 2026-08-03 |
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Diffuse Intrinsic Pontine Glioma (118) · Glioma (62) · Brain Neoplasms (40) · Glioblastoma (31) · Medulloblastoma (27) · Astrocytoma (26) · Brain Stem Neoplasms (15) · Ependymoma (14) · Central Nervous System Neoplasms (12) · Rhabdoid Tumor (12) · Neoplasms (11) · Recurrence (10) · Gliosarcoma (9) · Neuroectodermal Tumors, Primitive (9)
Central Nervous System Diseases (157) · Neoplasms by Site (157) · Nervous System Diseases (157) · Brain Diseases (156) · Nervous System Neoplasms (156) · Neoplasms (147) · Central Nervous System Neoplasms (146) · Neoplasms by Histologic Type (133) · Neoplasms, Nerve Tissue (133) · Neuroectodermal Tumors (133) · Neoplasms, Glandular and Epithelial (132) · Neoplasms, Germ Cell and Embryonal (129) · Neoplasms, Neuroepithelial (127) · Brain Neoplasms (118)
Temozolomide (15) · Radiotherapy (12) · Everolimus (7) · Bevacizumab (6) · Cyclophosphamide (6) · Irinotecan (6) · Dasatinib (4) · Panobinostat (4) · Radiation (4) · ribociclib (4) · Etoposide (3) · Gemcitabine (3) · Nivolumab (3) · Re-Irradiation (3) · Specimen Handling (3)
National Cancer Institute (NCI) (10) · Nationwide Children's Hospital (10) · M.D. Anderson Cancer Center (5) · St. Jude Children's Research Hospital (5) · Children's Cancer Hospital Egypt 57357 (4) · Children's Hospital Medical Center, Cincinnati (4) · Pediatric Brain Tumor Consortium (4) · Sabine Mueller, MD, PhD (4) · Children's National Research Institute (3) · Children's Oncology Group (3) · Kasr El Aini Hospital (3) · University of Florida (3) · University of Michigan Rogel Cancer Center (3) · Ann & Robert H Lurie Children's Hospital of Chicago (2) · Baylor College of Medicine (2)
United States (102) · Canada (16) · Australia (13) · Germany (13) · China (10) · Spain (9) · Italy (8) · New Zealand (8) · Egypt (7) · France (7) · United Kingdom (6) · Netherlands (5) · Belgium (4) · Switzerland (4) · Turkey (Türkiye) (4)
Maryam Fouladi, MD (8) · Margot Lazow, MD (4) · Alberto Broniscer, MD (2) · Amar Gajjar, MD (2) · Carl Koschmann, M.D. (2) · Hongwei Zhang, Prof. (2) · John W Glod, M.D. (2) · Rebecca Ronsley, MD (2) · Sabine Mueller, MD, PhD (2) · Sabine Mueller, MD, PhD, MAS (2) · Stewart Goldman, MD (2) · Susan Chi, MD (2) · Adam Green, MD (1) · Allan H Friedman, MD (1)
PMID 10627774, PMID 10655437, PMID 11907388, PMID 11937316, PMID 12177103, PMID 12234639, PMID 12434281, PMID 1408229, PMID 14506149, PMID 14625709, PMID 14669535, PMID 16011702, PMID 16078267, PMID 16265674, PMID 16510333, PMID 16598416, PMID 16645718, PMID 16890064, PMID 17544337, PMID 17647306, PMID 17909941, PMID 18217208, PMID 18577561, PMID 18990510, PMID 19147777, PMID 19223865, PMID 19262392, PMID 19957326, PMID 19985059, PMID 20479675, PMID 20694800, PMID 20708924, PMID 20921456, PMID 20974795, PMID 21087935, PMID 21171927, PMID 21292687, PMID 21297126, PMID 21297433, PMID 21327862, PMID 21957628, PMID 21971206, PMID 22132908, PMID 2229331, PMID 22331797, PMID 22492959, PMID 22747087, PMID 22747092, PMID 23043252, PMID 23092726
UM1CA081457 (5), UM1CA097452 (3), 2009 (2), 2014 (2), 2015 (2), 2023 (2), U01CA081457 (2), 1RC2CA148491-01 (1), 2019 (1), 5UM1CA081457 (1), P30CA015083 (1), P30CA016672 (1), R01CA187079 (1), R01CA187202 (1), R01CA229646 (1)