36 completed, 7 recruiting, 5 unknown, 1 active not recruiting. 41 Not applicable, 2 Phase 2, 2 Phase 4, 1 Early Phase 1, 1 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial of a Voice-Based Generative AI Emotional Support Companion The intervention was the AI-based emotional support app., Psychoeducational Material - Anxiety and Fear | Not applicable | Completed | University of Cologne | 400 | 2025-11-14 | 2026-10-06 |
| Effects of Liquid Hourglass and Spiky Ball on Pain, Fear, Anxiety and Emotional Manifestations Liquid Hourglass, Spiky Ball - Pain, Anxiety and Fear | Not applicable | Completed | Hakkari Universitesi | 120 | 2025-10-01 | 2026-02-11 |
| Virtual Reality to Reduce Stress Among Nursing Students Before Final Exams Self-Selected Virtual Reality Relaxation Session - Stress (Psychology), Anxiety and Fear | Not applicable | Completed | University of Bisha | 50 | 2025-07-25 | 2026-05-07 |
| The Effect of Financial Literacy Education on Financial Literacy and Future Anxiety in Final-Year Nursing Students Financial Literacy Education - Literacy, Anxiety and Fear | Not applicable | Completed | Saglik Bilimleri Universitesi | 68 | 2025-05-27 | 2025-07-30 |
| K08 VR Fear Conditioning Deep Brain Stimulation - Anxiety and Fear, PTSD | Not applicable | Recruiting | University of California, Los Angeles | 70 | 2025-03-01 | 2026-10-13 |
| Effectiveness of a Digital Application for Adolescents With Mild to Moderate Anxiety Modi, Treatment as usual - Anxiety, Anxiety and Fear | Not applicable | Recruiting | Haukeland University Hospital | 128 | 2025-01-16 | 2025-08-28 |
| Effect of Short Film Video Training Prepared for Children Undergoing Bone Marrow Aspiration and Biopsy Short film video - Anxiety and Fear, Pain | Not applicable | Completed | Tarsus University | 60 | 2024-12-19 | 2026-01-08 |
| Evaluation of the Efficacy of a Virtual Reality When Placing a Needle on an Implantable Venous Access Device in Children With Leukemia Hypnotic Virtual reality, Interactive virtual reality, Standard method - Virtual Reality, Children and Adolescents | Not applicable | Recruiting | University Hospital, Clermont-Ferrand | 120 | 2024-11-15 | 2025-12-04 |
| Cannabidiol Effects on Learning and Anxiety Cannabidiol Oral Product, Placebo - Anxiety and Fear | Early Phase 1 | Recruiting | University of Connecticut | 160 | 2024-10-30 | 2026-04-29 |
| Virtual Reality as a Digital Premed to Alleviate Pain and Anxiety Preoperatively in Patients Undergoing Spine Surgery Virtual Reality - Anxiety and Fear, Pain, Postoperative | Not applicable | Recruiting | Medical University of Lodz | 150 | 2024-08-16 | 2025-04-08 |
| The Effect of Projector Kaleidoscope and Cartoons on Anxiety, Fear, and Pain in Children Projector Kaleidoscope, Cartoon - Anxiety and Fear, Pain | Not applicable | Completed | Tarsus University | 90 | 2024-06-01 | 2024-11-20 |
| Effect of Inhalation Therapy on Children's Fear and Anxiety Levels and Physiological Parameters Fish-shaped nebulizer and fish-shaped toy, Silent nebulizer - Anxiety and Fear | Not applicable | Completed | Recep Tayyip Erdogan University | 90 | 2024-05-01 | 2025-08-01 |
| Virtual Reality Used During Tooth Extraction and Extirpation Treatment virtual reality glasses used during tooth extraction and extirpation treatment - Anxiety and Fear, Tooth Disease | Not applicable | Completed | Murat Bektaş | 120 | 2024-04-01 | 2025-03-21 |
| Flashforward EMDR Treatment for Patients With an ICD Flashforward EMDR, Flashback EMDR - Anxiety and Fear | Not applicable | Unknown | Erasmus Medical Center | 33 | 2024-02-01 | 2023-12-19 |
| The Effect of Therapeutic Play on Children's Anxiety and Fear Before Lumbar Puncture Theraputic Play - Anxiety and Fear | Not applicable | Completed | Maltepe University | 34 | 2024-01-15 | 2024-06-05 |
| Evaluation of the Effectiveness of a Nursing Intervention Program in Reducing Anxiety in Users Who Perform Scheduled Sessions in the Hyperbaric Chamber Intervention group - Anxiety and Fear, Nurse's Role | Not applicable | Recruiting | Universitat de Girona | 42 | 2024-01-06 | 2026-05-06 |
| Determining the Efficacy of Essential Oil Aromatherapy in Children Undergoing Port Access STILL QuickTAB Medipack blended scent aromatherapy, manufactured by Soothing Scents - Anxiety and Fear, Pain | Not applicable | Completed | Stanford University | 23 | 2023-12-05 | 2024-12-13 |
| Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression Lorazepam, Placebo - Depression, Anxiety, Fear | Phase 4 | Recruiting | Laureate Institute for Brain Research, Inc. | 165 | 2023-11-08 | 2025-10-31 |
| Investigating the Effect of Art Therapy on Women With Fear of Childbirth During Pregnancy: A Mixed Method Study Art Therapy - Fear of Childbirth, Pregnancy Related | Not applicable | Unknown | KK Women's and Children's Hospital | 100 | 2023-11-02 | 2024-03-05 |
| Art as Healing: A Community-informed Art-based Programme (CiAbP) for Reintegrating Ex-offenders Into Society in Nigeria Community-informed art-based programme, Government Media Intervention - Trauma, Depression | Not applicable | Unknown | Teesside University | 60 | 2023-09-01 | 2022-11-23 |
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Anxiety Disorders (51) · Pain (9) · Depression (5) · Acute Pain (4) · Child Behavior (3) · COVID-19 (2) · Pain, Procedural (2) · Stress Disorders, Post-Traumatic (2) · Behavior (1) · Depressive Disorder (1) · Diabetes Mellitus (1) · Feeding Behavior (1) · Feeding and Eating Disorders (1) · Health Behavior (1) · Heart Arrest (1)
Mental Disorders (50) · Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (14) · Neurologic Manifestations (13) · Behavior (11) · Behavioral Symptoms (6) · Pain (4) · Coronaviridae Infections (2) · Coronavirus Infections (2) · Infections (2) · Lung Diseases (2) · Neoplasms by Site (2) · Nidovirales Infections (2) · Pneumonia (2) · Pneumonia, Viral (2)
Surveys and Questionnaires (2) · Therapeutics (2) · Vaginal Creams, Foams, and Jellies (2) · 4-amino-4'-hydroxylaminodiphenylsulfone (1) · Art Therapy (1) · Cannabidiol (1) · Deep Brain Stimulation (1) · Dexmedetomidine (1) · Lorazepam (1) · Midazolam (1) · Music Therapy (1) · Nitrous Oxide (1) · Oxygen (1) · Play Therapy (1) · Saline Solution (1)
Selcuk University (3) · Laureate Institute for Brain Research, Inc. (2) · Tarsus University (2) · University Hospital, Clermont-Ferrand (2) · Aga Khan University (1) · Althaia Xarxa Assistencial Universitària de Manresa (1) · Ankara Yildirim Beyazıt University (1) · Beth Israel Deaconess Medical Center (1) · Butler Hospital (1) · CHI MONT DE MARSAN ET PAYS DES SOURCES (1) · Centre for Addiction and Mental Health (1) · Columbia University (1) · Dokuz Eylul University (1) · Erasmus Medical Center (1) · Fatih Sultan Mehmet Training and Research Hospital (1)
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Maria Ironside, DPhil (2) · Alexandra Bouvard, MD (1) · Annette Nasr, PhD (1) · Arzu Atici, MD (1) · Ashley Welch, MD (1) · Atiye Karakul (1) · Bernhard Kulzer, Prof, PhD (1) · Bruno Aouizerate, MD-PhD (1) · Cyril Dejean, PhD (1) · Cyril Herry, PhD (1) · Dilek Demir, PhD (1) · Duygu Silte Karamanlioglu, MD (1) · Faruk Cicekci (1)
PMID 26969158, PMID 27157961, PMID 28779942, PMID 30362982, PMID 30711327, PMID 31743795, PMID 31969473, PMID 32891272, PMID 34328428, PMID 35811050, PMID 36322113, PMID 36991460, PMID 38030988, PMID 40359712, PMID 42475850, PMID 42500320, PMID 42614770, PMID 42766003
K08MH138741 (1), P20GM121312 (1), P30AG064198 (1), R01MH132565 (1)