5 completed, 2 terminated, 2 withdrawn, 1 not yet recruiting. 12 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 12 | Completed 5, Terminated 2, Withdrawn 2, Not yet recruiting 1, Recruiting 1, Unknown 1 |
Follow Amyloidosis: new trials by email Literature Review of Amyloidosis trials Research Report on Amyloidosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Pilot Study of Anselamimab in Patients With AL Amyloidoma and Measurable Tissue Involvement Anselamimab - AL Amyloidosis | Early Phase 1 | Not yet recruiting | Stanford University | 5 | 2026-09-01 | 2026-10-27 |
| Safety and Efficacy of Metabolically Armed BCMA CAR-T Cells (Meta10-BCMA) in the Treatment of r/r Plasma Cell Neoplasms Clinical Research Metabolically Armed BCMA CAR-T cells. - Multiple Myeloma (MM), Plasma Cell Leukemia (PCL) | Early Phase 1 | Recruiting | Anhui Provincial Hospital | 36 | 2025-06-23 | 2025-07-25 |
| Autologous BCMA-targeted CAR-T Cell Injection for Relapsed/Refractory Light Chain Amyloidosis Targeted BCMA Autologous CART Cell Injection - Relapsed/Refractory Light Chain Amyloidosis, AL Amyloidosis | Early Phase 1 | Withdrawn | Beijing Boren Hospital | 2024-12-16 | 2026-10-13 | |
| Spectrum of Peripheral and Autonomic Neuropathies in Patients With aTTRwt Amyloidosis and Response to Patisiran Therapy patisiran - Polyneuropathies, Wild Type ATTR Amyloidosis | Early Phase 1 | Completed | Austin Neuromuscular Center | 10 | 2022-08-03 | 2026-05-22 |
| Selinexor for Treatment of Light Chain Amyloidosis With Relapsed/Refractory Disease Selinexor, Dexamethasone - Amyloid, Amyloidosis | Early Phase 1 | Withdrawn | Weill Medical College of Cornell University | 2021-12-01 | 2022-11-17 | |
| A Clinical Study of CD19/BCMA CAR-T Cells in the Treatment of Refractory POEMS Syndrome, Amyloidosis, Autoimmune Hemolytic Anemia, and Vasculitis CD19/BCMA CAR T-cells - POEMS Syndrome, Amyloidosis | Early Phase 1 | Unknown | Zhejiang University | 75 | 2021-10-08 | 2022-03-03 |
| Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients With Light Chain Amyloidosis Using PET/CT FNOS, Florbetaben - Cardiac Amyloidosis | Early Phase 1 | Terminated | University of Pennsylvania | 3 | 2019-10-01 | 2024-11-12 |
| Short-term Effects of TOLCAPONE on Transthyretin Stability in Subjects With Leptomeningeal TTR Amyloidosis (ATTR) Tolcapone - Transthyretin Amyloidosis, Amyloidosis, Leptomeningeal, Transthyretin-Related | Early Phase 1 | Completed | Boston University | 10 | 2018-10-30 | 2019-06-14 |
| Transthyretin Cardiac Amyloidosis in HFpEF 99mTc-PYP - Heart Failure With Preserved Ejection Fraction | Early Phase 1 | Completed | Mayo Clinic | 287 | 2017-12-01 | 2021-03-19 |
| Assessment of Cardiac Fixation During PET Using a New Drug Within Amyloid Cardiac Injuries. PET with 18 F-Flutemetamol - Cardiac Amyloidosis | Early Phase 1 | Terminated | University Hospital, Toulouse | 7 | 2017-03-15 | 2020-08-26 |
| PET/MRI Evaluation of Cardiac Amyloid 18F-Florbetaben (Neuraceq®) PET/MRI - Cardiac Amyloidosis | Early Phase 1 | Completed | Stanford University | 9 | 2016-05-26 | 2019-07-17 |
| Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal Metastases Pemetrexed - Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders | Early Phase 1 | Completed | Northwestern University | 15 | 2007-01-01 | 2021-09-08 |
Immunoglobulin Light-chain Amyloidosis (5) · Amyloid Neuropathies, Familial (4) · Amyloidosis, Hereditary, Transthyretin-Related (2) · Multiple Myeloma (2) · Alzheimer Disease (1) · Anemia, Hemolytic, Autoimmune (1) · Blast Crisis (1) · Brain Neoplasms (1) · Burkitt Lymphoma (1) · Central Nervous System Neoplasms (1) · Congenital Abnormalities (1) · Heart Failure (1) · Heart Failure, Diastolic (1) · Hodgkin Disease (1)
Metabolic Diseases (12) · Nutritional and Metabolic Diseases (12) · Proteostasis Deficiencies (12) · Nervous System Diseases (7) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Immune System Diseases (6) · Immunoproliferative Disorders (6) · Paraproteinemias (6) · Neoplasms (5) · Neoplasms by Histologic Type (5) · Neurodegenerative Diseases (5) · Neuromuscular Diseases (5) · Peripheral Nervous System Diseases (5) · Amyloid Neuropathies (4)
4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Dexamethasone (1) · Pemetrexed (1) · Technetium Tc 99m Pyrophosphate (1) · Tolcapone (1) · flutemetamol (1) · patisiran (1) · selinexor (1)
Stanford University (2) · Anhui Provincial Hospital (1) · Austin Neuromuscular Center (1) · Beijing Boren Hospital (1) · Boston University (1) · Mayo Clinic (1) · Northwestern University (1) · University Hospital, Toulouse (1) · University of Pennsylvania (1) · Weill Medical College of Cornell University (1) · Zhejiang University (1)
United States (8) · China (3) · France (1)
Andrei Iagaru, MD (1) · Cara Rosenbaum, MD (1) · He Huang, PhD (1) · Jeffrey J. Raizer, MD (1) · John L Berk, MD (1) · Michaela Liedtke, MD (1) · Omar F Abou Ezzeddine (1) · Paco Bravo (1)