20 completed, 4 unknown, 2 terminated, 1 active not recruiting. 14 Phase 2, 6 Phase 1, 3 Early Phase 1, 3 Not applicable, 2 Phase 4.
Follow this drug Literature Review of Tolcapone trials Research Report on Tolcapone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder Tolcapone, Placebo - Obsessive-Compulsive Disorder, OCD | Phase 2 | Completed | University of Chicago | 49 | 2023-06-22 | 2026-09-23 |
| Microbiome Derived Metabolism and Pharmacokinetics Tolcapone 100 MG, Duloxetine 20 MG - Microbial Colonization | Phase 1 | Completed | Rutgers, The State University of New Jersey | 17 | 2022-02-01 | 2026-04-29 |
| COMT Inhibition Among Individuals With Comorbid AUD/ADHD Tolcapone, Placebo - Alcohol Use Disorder, Attention Deficit Hyperactivity Disorder | Phase 2 | Completed | University of Colorado, Denver | 23 | 2021-08-16 | 2026-05-04 |
| Dopaminergic Mechanisms Underlying Human Social Behavior Tolcapone 200 MG, Functional Magnetic Resonance Imaging (fMRI) - Decision Making, Executive Function | Early Phase 1 | Completed | University of California, Berkeley | 70 | 2019-12-01 | 2024-05-16 |
| Short-term Effects of TOLCAPONE on Transthyretin Stability in Subjects With Leptomeningeal TTR Amyloidosis (ATTR) Tolcapone - Transthyretin Amyloidosis, Amyloidosis, Leptomeningeal, Transthyretin-Related | Early Phase 1 | Completed | Boston University | 10 | 2018-10-30 | 2019-06-14 |
| A Study Assessing the Safety and Pharmacokinetic Profile of Modified Release Formulations of Tolcapone Tolcapone, Tolcapone Modified Release Prototype, Tolcapone Divided Dose - Healthy Volunteers | Phase 1 | Completed | Corino Therapeutics, Inc. | 12 | 2018-06-25 | 2019-01-31 |
| Tolcapone in Obsessive Compulsive Disorder Tolcapone 200 MG - Obsessive-Compulsive Disorder | Phase 2 / Phase 3 | Completed | University of Chicago | 20 | 2018-03-20 | 2022-04-07 |
| A Trial Evaluating Effects of COMT Inhibition in Patients With Acquired Brain Injury Tolcapone 200 MG, Placebo - Brain Injuries, Brain Injuries, Traumatic | Phase 2 | Unknown | Sheppard Pratt Health System | 16 | 2017-07-20 | 2017-09-06 |
| Effects of Tolcapone on Decision Making and Alcohol Intake in Alcohol Users Tolcapone, Placebo - Alcohol Abuse, Impulsive Behavior | Phase 2 | Completed | Jennifer Mitchell | 62 | 2016-10-01 | 2020-09-21 |
| Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control Tolcapone, Placebo - Alcohol Use Disorder | Phase 2 | Completed | Medical University of South Carolina | 90 | 2016-05-01 | 2023-06-09 |
| Gait Analysis in Neurological Disease Anti-Parkinson medication, Deep Brain Stimulation - Parkinson's Disease, Parkinsonian Disorders | Active not recruiting | Beth Israel Deaconess Medical Center | 120 | 2016-03-01 | 2026-07-08 | |
| Trial of Tolcapone With Oxaliplatin for Neuroblastoma Tolcapone, Oxaliplatin - Neuroblastoma | Phase 1 | Terminated | Giselle Sholler | 5 | 2015-12-01 | 2024-08-06 |
| Evaluate the Effects of Tolcapone on Cognitive and Behavioral Dysfunction in Patients With BI and NCD Tolcapone - Brain Injuries, Traumatic, Neurocognitive Disorders | Phase 2 | Unknown | Sheppard Pratt Health System | 100 | 2015-11-01 | 2017-01-19 |
| Treatment for Nicotine Addiction in Women Tolcapone, Sugar Pill - Nicotine Dependence | Not applicable | Completed | Yale University | 36 | 2015-10-23 | 2020-11-24 |
| Remediation of Impaired Self-Regulation in Patients With Mild TBI Tolcapone, Placebo - Mild Traumatic Brain Injury | Early Phase 1 | Completed | VA Office of Research and Development | 55 | 2015-08-01 | 2025-09-22 |
| Evaluation of Tolcapone as a Cognitive Enhancer in Schizophrenia Tolcapone - Schizophrenia | Phase 2 | Unknown | Clinica Universidad de Navarra, Universidad de Navarra | 20 | 2014-09-22 | 2024-04-29 |
| Dopamine Responsivity in Gamblers Tolcapone, Placebo - Pathological Gambling | Not applicable | Completed | University of California, San Francisco | 19 | 2014-08-01 | 2021-02-16 |
| Study of SOM0226 in Familial Amyloid Polyneuropathy SOM0226 - Familial Amyloid Polyneuropathy (FAP) | Phase 1 / Phase 2 | Completed | SOM Innovation Biotech SA | 17 | 2014-07-01 | 2016-11-30 |
| Dopaminergic Modulation of Frontostriatal Function With a Dopamine Agonist and COMT Inhibitor Tolcapone, Placebo, Bromocriptine - Addiction | Phase 4 | Withdrawn | University of California, Berkeley | 2013-07-01 | 2021-11-16 | |
| Role of the Catechol-O-methyltransferase (COMT) in the Physiological Regulation of Vigilance Tolcapone, Placebo - Healthy | Phase 1 | Completed | University of Zurich | 30 | 2013-06-01 | 2014-09-12 |
Showing 20 of 28. Sign in to see all of them.
Alcoholism (3) · Impulsive Behavior (3) · Tobacco Use Disorder (3) · Amyloidosis (2) · Behavior, Addictive (2) · Brain Injuries (2) · Brain Injuries, Traumatic (2) · Gambling (2) · Obsessive-Compulsive Disorder (2) · Parkinson Disease (2) · Schizophrenia (2) · Amyloid Neuropathies, Familial (1) · Amyloidosis, Hereditary, Transthyretin-Related (1) · Attention Deficit Disorder with Hyperactivity (1) · Brain Concussion (1)
University of Chicago (3) · Sheppard Pratt Health System (2) · University of California, Berkeley (2) · University of California, San Francisco (2) · University of Pennsylvania (2) · Beth Israel Deaconess Medical Center (1) · Boston University (1) · Clinica Universidad de Navarra, Universidad de Navarra (1) · Columbia University (1) · Corino Therapeutics, Inc. (1) · Giselle Sholler (1) · Jennifer Mitchell (1) · Medical University of South Carolina (1) · National Institute of Mental Health (NIMH) (1) · National Institute on Drug Abuse (NIDA) (1)
United States (22) · Spain (2) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Jennifer Mitchell, PhD (2) · Robert J Schloesser, MD (2) · Andrew Kayser, MD, PhD (1) · Andrew Kayser, MD,PhD (1) · Andrew S Kayser, MD PhD (1) · Caryn Lerman, Ph.D. (1) · Caryn Lerman, PhD (1) · Christian Baumann, MD (1) · Dag Nyholm, MD, PhD (1) · Edward Huey, MD (1) · Elise DeVito, Ph.D. (1) · Hans-Peter Landolt, Professor (1) · Howard Fields, MD, PhD (1) · James Loughead, Ph.D. (1) · Jessica Foley, MD (1)
PMID 22764248, PMID 23794107, PMID 23953269, PMID 28066708, PMID 31119947, PMID 32617646, PMID 34253715, PMID 35523943
2014 (1), 2017 (1), I01RX000825 (1), P50AA010761 (1), R00NS060766 (1), R01AA026859 (1), R01DA026849 (1), R21DA038253 (1)