8 recruiting, 8 unknown, 4 completed, 2 not yet recruiting. 6 Not applicable, 3 Phase 3, 2 Phase 2, 2 Phase 4, 1 Phase 1.
Follow Amyloid Cardiomyopathy: new trials by email Literature Review of Amyloid Cardiomyopathy trials Research Report on Amyloid Cardiomyopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE) Acoramidis (AG10) - Amyloidosis in Transthyretin (TTR), Amyloidosis, Familial | Phase 3 | Not yet recruiting | Eidos Therapeutics, a BridgeBio company | 250 | 2026-11-01 | 2026-08-11 |
| Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis Acoramidis (AG10) oral tablet - Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM), Amyloidosis | Phase 4 | Recruiting | Eidos Therapeutics, a BridgeBio company | 150 | 2026-07-01 | 2026-07-29 |
| Hungarian National Systemic Amyloidosis Registry Systemic Amyloidosis, ATTR Amyloidosis | Recruiting | Semmelweis University | 300 | 2026-03-08 | 2026-07-08 | |
| Enavogliflozin for the Management of Patients With Amyloid CardiomyopaThy Enavogliflozin 0.3mg, Placebo - Amyloid Cardiomyopathy | Phase 4 | Recruiting | Seoul St. Mary's Hospital | 68 | 2026-01-06 | 2026-06-18 |
| Myocardial Perfusion CMR for Differentiating and Characterizing Hypertrophic Cardiomyopathy Phenotypes HCM - Hypertrophic Cardiomyopathy, Anderson Fabry Disease | Recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 250 | 2025-06-01 | 2026-02-02 | |
| Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant Acoramidis, Placebo oral tablet - Amyloidosis, Amyloid Cardiomyopathy | Phase 3 | Recruiting | Eidos Therapeutics, a BridgeBio company | 587 | 2025-05-12 | 2026-08-04 |
| AI-enabled Screening and Diagnosis of Cardiomyopathies Using Coronary CTA CCTAI model - Cardiovascular Diseases, Hypertrophic Cardiomyopathy (HCM) | Not yet recruiting | Shanghai Zhongshan Hospital | 5000 | 2024-12-30 | 2024-12-27 | |
| EOSS-ATTR Study (eHealth Based Operative Support System in ATTR-CM) mHealth - Heart Failure, Amyloid Cardiomyopathy | Not applicable | Unknown | Hospital Universitari de Bellvitge | 50 | 2024-12-01 | 2024-10-23 |
| Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy Genistein - Amyloid Cardiomyopathy | Phase 1 / Phase 2 | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 20 | 2024-09-27 | 2025-06-15 |
| Exercise Training in Transthyretin Cardiac Amyloidosis Exercise Training - Amyloid Cardiomyopathy, Transthyretin Cardiac Amyloidosis | Not applicable | Recruiting | Brigham and Women's Hospital | 40 | 2024-07-10 | 2025-03-18 |
| Association Between Lifetime Physical Activity and Exercise and the Development of Wild-type Transthyretin Amyloid Cardiomyopathy Interview - Amyloid Cardiomyopathy, Wild Type ATTR Amyloidosis | Completed | Medical University of Graz | 180 | 2024-02-16 | 2026-05-01 | |
| 18F-florbetaben PET-CT to Non-invasively Diagnose Cardiac AL Amyloidosis 18F-florbetaben PET/CT - Amyloid, Amyloid Cardiomyopathy | Not applicable | Unknown | Fondazione Toscana Gabriele Monasterio | 150 | 2023-01-26 | 2023-09-21 |
| Screening of ATTRwt in Patient With Advanced AV-Block Undergoing Pacemaker Implantation Amyloidosis screening (bloodtest, DPD-scintigraphy, potentially endomyocardial biopsy) - Amyloid Cardiomyopathy, Block, AV | Unknown | Steen Hvitfeldt Poulsen | 170 | 2022-10-01 | 2023-06-02 | |
| Longitudinal Changes in Left and Right Ventricular Global Strain After Chemotherapy in Cardiac Light Chain Amyloidosis Left and Right Ventricular Global Strain Imaging - Amyloid Cardiomyopathy, Congestive Heart Failure | Unknown | Istanbul University - Cerrahpasa | 30 | 2022-08-11 | 2023-09-28 | |
| Left Atrial Strain and Supraventricular Arrhythmia Burden in Cardiac Light Chain Amyloidosis Following Chemotherapy Left Atrial Strain Imaging, Electrocardiography - Supraventricular Arrhythmia, Left Atrial Abnormality | Unknown | Istanbul University - Cerrahpasa | 30 | 2022-08-10 | 2023-09-28 | |
| Administration of the SGLT-2 Inhibitor Dapagliflozin in the Patients With Amyloid Cardiomyopathy Dapagliflozin 10mg Tab, Placebo - Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction | Not applicable | Completed | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | 50 | 2022-06-01 | 2026-04-24 |
| Amyloidosis TTR Flow Reserve Evaluation SPECT MPI - Amyloid Cardiomyopathy | Not applicable | Active not recruiting | Centre Hospitalier Régional d'Orléans | 50 | 2022-02-24 | 2025-12-23 |
| Artificial Intelligence to Assist the Echocardiographic Identification of Transthyretin Cardiac Amyloidosis non interventional study - Amyloid Cardiomyopathy, Transthyretin Amyloid Cardiomyopathy | Unknown | Algalarrondo Vincent | 15000 | 2022-01-01 | 2024-03-25 | |
| Unmasking the Prevalence of AC in an Unselected Echocardiographic Population Amyloid Cardiomyopathy - Amyloid Cardiomyopathy | Unknown | University of Trieste | 381 | 2020-11-20 | 2021-02-04 | |
| Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy acoramidis, Placebo Oral Tablet - Amyloidosis, Amyloid Cardiomyopathy | Phase 3 | Completed | Eidos Therapeutics, a BridgeBio company | 632 | 2019-03-19 | 2024-06-27 |
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Amyloid Neuropathies, Familial (24) · Cardiomyopathies (8) · Alzheimer Disease (7) · Amyloidosis (7) · Amyloidosis, Hereditary, Transthyretin-Related (5) · Heart Failure (4) · Heart Diseases (3) · Cardiomyopathy, Hypertrophic (2) · Immunoglobulin Light-chain Amyloidosis (2) · Polyneuropathies (2) · Amyloidosis, Familial (1) · Arrhythmias, Cardiac (1) · Arrhythmogenic Right Ventricular Dysplasia (1) · Atrioventricular Block (1) · Cardiomyopathy, Dilated (1)
Amyloid Neuropathies (24) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (24) · Genetic Diseases, Inborn (24) · Heredodegenerative Disorders, Nervous System (24) · Metabolic Diseases (24) · Metabolism, Inborn Errors (24) · Nervous System Diseases (24) · Neurodegenerative Diseases (24) · Neuromuscular Diseases (24) · Nutritional and Metabolic Diseases (24) · Peripheral Nervous System Diseases (24) · Proteostasis Deficiencies (24) · Amyloidosis, Familial (23) · Amyloidosis (17) · Cardiovascular Diseases (11)
attruby (5) · Electrocardiography (1) · Enavogliflozin (1) · Exercise (1) · Genistein (1) · Interviews as Topic (1) · Radiotherapy (1) · Tablets (1) · Telemedicine (1) · dapagliflozin (1)
Eidos Therapeutics, a BridgeBio company (5) · Istanbul University - Cerrahpasa (2) · Algalarrondo Vincent (1) · Brigham and Women's Hospital (1) · Centre Hospitalier Régional d'Orléans (1) · Fondazione Toscana Gabriele Monasterio (1) · Hospital Universitari de Bellvitge (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Insel Gruppe AG, University Hospital Bern (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Medical University of Graz (1) · National Medical Research Center for Cardiology, Ministry of Health of Russian Federation (1) · Philippe Meyer (1) · Semmelweis University (1) · Seoul St. Mary's Hospital (1)
United States (6) · Italy (5) · Canada (3) · Denmark (3) · France (3) · South Korea (3) · Australia (2) · Belgium (2) · Brazil (2) · Greece (2) · Ireland (2) · Netherlands (2) · Portugal (2) · Spain (2) · Switzerland (2)
Deniz Mutlu, MD (2) · Chenguang Li, MD, PhD (1) · Claudio Rapezzi, MD, Full Professor (1) · Gabriel Steg, MD, PhD (1) · Gianfranco Sinagra, MD, Full Professor (1) · Jong-Chan Youn, MD, PhD (1) · Mark JK Chandy, MD PhD (1) · Mazen A Hanna, MD (1) · Nicolas Verheyen, Res Prof, MD PhD (1) · Sergi Yun Viladomat, MD (1) · Steen Poulsen, MD (1) · Zoltan Pozsonyi, MD, PhD (1)
PMID 34396169, PMID 42389794, PMID 27339491, PMID 29596561, PMID 33725199, PMID 34729522, PMID 35323616, PMID 35417089, PMID 35811735, PMID 36082269, PMID 37621153, PMID 38197816, PMID 38724281, PMID 38866445, PMID 39878480, PMID 40074465, PMID 40216220, PMID 40398971, PMID 40750720, PMID 41205147, PMID 41384357, PMID 41804669, PMID 42110872, PMID 42216490, PMID 42307157, PMID 42488169, PMID 42525404, PMID 42554365, PMID 42622768, PMID 42669902
2017 (1), 2018 (1)