4 completed, 1 not yet recruiting, 1 recruiting. 6 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 4, Not yet recruiting 1, Recruiting 1 |
Follow Amebiasis: new trials by email Literature Review of Amebiasis trials Research Report on Amebiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Diloxanide Furoate as Additional Luminal Agent Along With Metronidazole for the Treatment of Amoebic Liver Abscess Diloxanide furoate, Placebo - Liver Abscess, Amoebic Liver Abscess | Phase 3 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 220 | 2026-09-04 | 2026-09-10 |
| Parasitic Ulcer Treatment Trial Polyhexamethylene biguanide (PHMB), Topical corticosteroid, Topical placebo - Acanthamoeba Keratitis | Phase 3 | Recruiting | Jeremy Keenan, MD, MPH | 232 | 2024-07-01 | 2026-10-01 |
| Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin - Acanthamoeba Keratitis, Fungal Keratitis | Phase 3 | Completed | University of California, San Francisco | 330 | 2022-08-03 | 2026-09-03 |
| Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis PHMB 0.08%, Propamidine 0.1%, placebo - Acanthamoeba Keratitis | Phase 3 | Completed | SIFI SpA | 135 | 2017-08-13 | 2023-08-22 |
| Study of Nitazoxanide in the Treatment of Amebiasis in Adults and Adolescents Nitazoxanide - Amebiasis | Phase 3 | Completed | Romark Laboratories L.C. | 50 | 2004-02-01 | 2006-08-21 |
| Study of Nitazoxanide in the Treatment of Amebiasis in Children Nitazoxanide - Amebiasis | Phase 3 | Completed | Romark Laboratories L.C. | 50 | 2004-02-01 | 2006-08-21 |
Acanthamoeba Keratitis (3) · Corneal Ulcer (1) · Liver Abscess (1) · Liver Abscess, Amebic (1)
Infections (6) · Parasitic Diseases (6) · Protozoan Infections (6) · Corneal Diseases (3) · Eye Diseases (3) · Eye Infections (3) · Eye Infections, Parasitic (3) · Keratitis (3) · Abdominal Abscess (1) · Abscess (1) · Digestive System Diseases (1) · Liver Diseases (1) · Liver Diseases, Parasitic (1) · Suppuration (1)
nitazoxanide (2) · polihexanide (2) · Adrenal Cortex Hormones (1) · Corneal Cross-Linking (1) · Natamycin (1) · Rose Bengal (1) · chlorhexidine gluconate (1) · dibrompropamidine (1) · diloxanide furoate (1) · tyramine-deoxysorbitol (1)
Romark Laboratories L.C. (2) · Jeremy Keenan, MD, MPH (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · SIFI SpA (1) · University of California, San Francisco (1)
India (3) · Brazil (2) · Egypt (2) · United Kingdom (2) · Italy (1) · Poland (1) · United States (1)
Samir M Kabil, MD (2) · Yehia El-Gohary, MD (2) · Gerami Seitzman, MD (1) · Jennifer Rose-Nussbaumer, MD (1) · Jeremy Keenan, MD, MPH (1) · John Dart, MD (1) · Nicole Varnado, MPH (1) · Tom Lietman, MD (1)
PMID 37802392, PMID 39011096, PMID 39192339, PMID 41561665, PMID 42348235
UG1EY028518 (1), UG1EY033284 (1)