11 recruiting. 11 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Recruiting 11 |
| Phase 1 | 4 | Recruiting 4 |
Follow Advanced Malignant Solid Neoplasm: new trials by email Literature Review of Advanced Malignant Solid Neoplasm trials Research Report on Advanced Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial) Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 2 | Recruiting | National Cancer Institute (NCI) | 500 | 2025-03-18 | 2026-10-20 |
| Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer Olanzapine, Placebo Administration, Questionnaire Administration - Advanced Malignant Solid Neoplasm, Advanced Biliary Tract Carcinoma | Phase 2 | Recruiting | OHSU Knight Cancer Institute | 66 | 2024-07-17 | 2026-07-16 |
| Siltuximab for the Prevention of Severe Immune-Related Adverse Events During Immune Checkpoint Inhibitor Rechallenge in Patients With Advanced Cancer, CIRES Trial Anti-PD-L1 Monoclonal Antibody, Anti-PD1 Monoclonal Antibody, Biopsy - Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm | Phase 2 | Recruiting | Yuanquan Yang | 40 | 2024-07-09 | 2026-09-28 |
| Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors Axatilimab, Biopsy, Biospecimen Collection - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 / Phase 2 | Recruiting | OHSU Knight Cancer Institute | 38 | 2024-05-21 | 2026-07-08 |
| Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Advanced Microsatellite Stable Colorectal Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 42 | 2023-09-28 | 2026-07-31 |
| At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer Clinical Encounter, Home Health Encounter, Quality-of-Life Assessment - Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 220 | 2023-08-23 | 2026-04-20 |
| Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies Hafnium Oxide-containing Nanoparticles NBTXR3, Radiation Therapy - Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Liver | Phase 1 / Phase 2 | Recruiting | M.D. Anderson Cancer Center | 40 | 2023-05-08 | 2026-07-30 |
| Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial Alpelisib, Binimetinib, Biopsy Procedure - Advanced Malignant Solid Neoplasm, Anatomic Stage III Breast Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 2900 | 2023-04-07 | 2026-11-02 |
| CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors Biospecimen Collection, Computed Tomography, Devimistat - Advanced Biliary Tract Carcinoma, Advanced Colorectal Carcinoma | Phase 2 | Recruiting | Northwestern University | 94 | 2023-03-08 | 2023-03-10 |
| Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors BET Bromodomain Inhibitor ZEN-3694, Computed Tomography, Core Biopsy - Advanced Malignant Solid Neoplasm, Locally Advanced Pancreatic Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 49 | 2022-11-16 | 2026-07-15 |
| Impact of Project ECHO on Improving the Quality of Palliative Care in Patients With Advanced Cancer and Their Caregivers in Underserved Areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia Extension of Community Health (ECHO) Telementoring Clinic, In-Country Workshops, Professional Oncology Educations Programs - Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 312 | 2020-08-24 | 2026-09-14 |
Neoplasm Metastasis (5) · Colorectal Neoplasms (3) · Ovarian Neoplasms (2) · Pancreatic Neoplasms (2) · Adenocarcinoma of Lung (1) · Anorexia (1) · Cachexia (1) · Carcinoma, Transitional Cell (1) · Endometrial Neoplasms (1) · Esophageal Neoplasms (1) · Fallopian Tube Neoplasms (1) · Hematologic Neoplasms (1) · Lung Neoplasms (1) · Multiple Myeloma (1) · Myelodysplastic Syndromes (1)
Neoplasms (9) · Neoplasms by Site (6) · Pathological Conditions, Signs and Symptoms (6) · Neoplastic Processes (5) · Pathologic Processes (5) · Digestive System Diseases (4) · Digestive System Neoplasms (4) · Colonic Diseases (3) · Endocrine Gland Neoplasms (3) · Endocrine System Diseases (3) · Gastrointestinal Diseases (3) · Gastrointestinal Neoplasms (3) · Intestinal Diseases (3) · Intestinal Neoplasms (3) · Rectal Diseases (3)
Magnetic Resonance Spectroscopy (6) · Specimen Handling (6) · Biopsy (5) · Fluorouracil (2) · Paclitaxel (2) · Taxes (2) · dehydroftorafur (2) · Alpelisib (1) · Biopsy, Large-Core Needle (1) · Biopsy, Needle (1) · Fulvestrant (1) · Gemcitabine (1) · Home Care Services (1) · House Calls (1) · Hydroxychloroquine (1)
National Cancer Institute (NCI) (4) · M.D. Anderson Cancer Center (2) · OHSU Knight Cancer Institute (2) · Mayo Clinic (1) · Northwestern University (1) · Yuanquan Yang (1)
United States (11) · Puerto Rico (1)
Devalingam Mahalingam (1) · Eric Roeland, M.D., FAAHPM, FASCO (1) · Funda Meric-Bernstam (1) · James M Ford (1) · Michael Cecchini (1) · Patricia M LoRusso (1) · Roxana S. Dronca, MD (1) · Saumil Gandhi, MD (1) · Shivaani Kummar (1) · Sriram Yennu (1) · Yuanquan Yang, MD, PhD (1)
UM1CA186689 (2), P30CA060553 (1), P30CA069533 (1), U10CA180820 (1), UM1CA186688 (1)