21 completed, 18 active not recruiting, 13 recruiting, 7 terminated. 65 Phase 1, 15 Phase 2.
Follow Advanced Malignant Solid Neoplasm: new trials by email Literature Review of Advanced Malignant Solid Neoplasm trials Research Report on Advanced Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TR-002 for the Treatment of Advanced Unresectable Metastatic Solid Tumors Unresectable or Metastatic, Refractory Pancreatic Adenocarcinoma TR-002 - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 | Recruiting | University of California, Davis | 52 | 2025-11-07 | 2026-07-16 |
| Studying TAK-243 in Patients With Advanced Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Lymphoma, Advanced Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 95 | 2025-03-24 | 2026-10-13 |
| Nab-Paclitaxel/STI-3031 Complex (AP160-Complex) for the Treatment of Advanced or Metastatic Solid Tumors Biopsy, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 | Withdrawn | Mayo Clinic | 2024-07-30 | 2025-01-07 | |
| Testing How the Body Responds to the Drug CBX-12 in Patients With Advanced Solid Cancers Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 35 | 2024-06-12 | 2026-10-15 |
| Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and Tuvusertib (M1774) for Advanced Solid Tumors Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 66 | 2024-06-07 | 2026-08-24 |
| Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors Axatilimab, Biopsy, Biospecimen Collection - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 / Phase 2 | Recruiting | OHSU Knight Cancer Institute | 38 | 2024-05-21 | 2026-07-08 |
| Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Advanced Microsatellite Stable Colorectal Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 42 | 2023-09-28 | 2026-07-31 |
| The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors Fermented Wheat Germ Extract - Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Phase 1 | Suspended | University of California, Davis | 100 | 2023-06-02 | 2026-07-01 |
| Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies Hafnium Oxide-containing Nanoparticles NBTXR3, Radiation Therapy - Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Liver | Phase 1 / Phase 2 | Recruiting | M.D. Anderson Cancer Center | 40 | 2023-05-08 | 2026-07-30 |
| AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Advanced Cholangiocarcinoma, Advanced Hepatocellular Carcinoma | Phase 1 | Suspended | University of Southern California | 36 | 2023-03-29 | 2026-08-17 |
| Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors BET Bromodomain Inhibitor ZEN-3694, Computed Tomography, Core Biopsy - Advanced Malignant Solid Neoplasm, Locally Advanced Pancreatic Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 49 | 2022-11-16 | 2026-11-12 |
| Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer BET Bromodomain Inhibitor ZEN-3694, Binimetinib, Biopsy Procedure - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 42 | 2022-08-02 | 2026-11-12 |
| Cabozantinib and Pamiparib for the Treatment of Advanced of Refractory Solid Tumors Cabozantinib, Pamiparib - Advanced Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm | Phase 1 | Completed | M.D. Anderson Cancer Center | 44 | 2022-02-09 | 2026-05-12 |
| Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV Biospecimen Collection, Cabozantinib S-malate, Computed Tomography - Advanced Differentiated Thyroid Gland Carcinoma, Advanced Head and Neck Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 8 | 2021-11-22 | 2026-05-28 |
| IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors Bevacizumab, Glutaminase-1 Inhibitor IACS-6274, Paclitaxel - Advanced Endometrial Carcinoma, Advanced Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 54 | 2021-09-30 | 2026-10-06 |
| Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer Cisplatin, Elimusertib, Gemcitabine Hydrochloride - Advanced Bile Duct Carcinoma, Advanced Breast Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 74 | 2021-08-25 | 2026-11-12 |
| Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial Biopsy Procedure, Biospecimen Collection, Ceralasertib - Advanced Breast Carcinoma, Advanced Colon Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 51 | 2021-08-09 | 2026-11-12 |
| Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer Trifluridine and Tipiracil Hydrochloride, Talazoparib Tosylate - Advanced Malignant Solid Neoplasm, Clinical Stage III Gastroesophageal Junction Adenocarcinoma | Phase 1 | Recruiting | Roswell Park Cancer Institute | 45 | 2021-06-08 | 2026-05-04 |
| Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors Biopsy Procedure, Biospecimen Collection, Diagnostic Imaging Testing - Advanced Fallopian Tube Carcinoma, Advanced Malignant Solid Neoplasm | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 14 | 2021-06-01 | 2026-07-31 |
| Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies Atezolizumab, Avelumab, Durvalumab - Advanced Bladder Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 19 | 2021-04-14 | 2026-04-30 |
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Neoplasm Metastasis (38) · Lung Neoplasms (9) · Ovarian Neoplasms (9) · Pancreatic Neoplasms (9) · Melanoma (8) · Triple Negative Breast Neoplasms (8) · Breast Neoplasms (5) · Carcinoma, Renal Cell (5) · Prostatic Neoplasms (5) · Carcinoma, Hepatocellular (4) · Colorectal Neoplasms (4) · Fallopian Tube Neoplasms (3) · HIV Infections (3) · Carcinoma, Non-Small-Cell Lung (2) · Colonic Neoplasms (2)
Neoplasms (58) · Pathologic Processes (39) · Pathological Conditions, Signs and Symptoms (39) · Neoplasms by Site (38) · Neoplastic Processes (38) · Neoplasms by Histologic Type (22) · Digestive System Diseases (20) · Digestive System Neoplasms (20) · Endocrine Gland Neoplasms (17) · Endocrine System Diseases (17) · Urogenital Diseases (17) · Skin Diseases (16) · Skin and Connective Tissue Diseases (16) · Genital Diseases (15) · Urogenital Neoplasms (15)
Specimen Handling (15) · Biopsy (13) · Magnetic Resonance Spectroscopy (12) · Nivolumab (8) · Paclitaxel (7) · Taxes (7) · CTLA-4 Antigen (6) · Ipilimumab (6) · Gemcitabine (4) · 1,2-diaminocyclohexaneplatinum II citrate (3) · Cisplatin (3) · Cyclophosphamide (3) · Disulfides (3) · Immunoglobulin G (3) · Pharmacogenomic Variants (3)
National Cancer Institute (NCI) (28) · M.D. Anderson Cancer Center (20) · Mayo Clinic (3) · Roswell Park Cancer Institute (3) · University of California, Davis (3) · University of Southern California (2) · Jonsson Comprehensive Cancer Center (1) · OHSU Knight Cancer Institute (1) · RasCal Therapeutics, Inc. (1) · Ronald Levy (1) · Tianhong Li (1) · University of Washington (1)
United States (63) · Canada (3) · Australia (1)
Timothy A Yap (6) · Patricia M LoRusso (3) · Siqing Fu (3) · Aung Naing (2) · Sarina A Piha-Paul (2) · Alex Adjei (1) · Alice P Chen (1) · Alison M Schram (1) · Anthony B El-Khoueiry, MD (1) · Anthony El-Khoueiry, MD (1) · Aung Naing, MD (1) · Christos Fountzilas, MD (1) · David S Hong (1) · Ecaterina E Dumbrava (1) · Edward J Kim, MD, PhD (1)
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