6 completed, 3 withdrawn, 2 not yet recruiting, 2 recruiting. 17 Phase 1, 7 Phase 2.
Follow Acute-On-Chronic Liver Failure: new trials by email Literature Review of Acute-On-Chronic Liver Failure trials Research Report on Acute-On-Chronic Liver Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure metra® Extracorporeal Liver Cross-Circulation (ELC) system (OrganOx), EGEN-5784 (genetically engineered porcine liver) - Acute on Chronic Liver Failure (ACLF), Hepatic Encephalopathy (HE) | Phase 1 / Phase 2 | Not yet recruiting | eGenesis, INC | 20 | 2026-10-01 | 2026-09-21 |
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF) umbilical cord Mesenchymal Stem Cell - Acute-On-Chronic Liver Failure | Phase 1 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 10 | 2026-01-01 | 2025-08-28 |
| Pharmacokinetic Study on G1090N (Nitazoxanide) Capsules in Healthy Volunteers Single Dose G1090N, Multiple dosing of G1090N - Acute-on-Chronic Liver Failure | Phase 1 | Completed | Genfit | 52 | 2025-08-26 | 2026-01-16 |
| Phase I Trial of QH-1A Hybrid Bio-Artificial Liver With Ex Vivo Blood-Purifying MSCs in Acute-on-Chronic Liver Failure Combining the QH-1A bioartificial liver device with mesenchymal stem cells for blood purification（4 hours）, Combining the QH-1A bioartificial liver device with mesenchymal stem cells for blood purification（6 hours）, Combining the QH-1A bioartificial liver device with mesenchymal stem cells for blood purification（8 hours） - Acute-On-Chronic Liver Failure | Phase 1 | Active not recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 15 | 2025-05-07 | 2025-05-30 |
| miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial miroliverELAP treatment - Acute Liver Failure, Acute Liver Injury, Drug Induced | Phase 1 | Completed | Miromatrix Medical Inc. | 10 | 2024-10-05 | 2026-03-06 |
| Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults a single course of micro-encapsulated hepatocytes intraperitoneal transplantation therapy - Acute-On-Chronic Liver Failure, Chronic Liver Failure | Phase 1 | Recruiting | RenJi Hospital | 10 | 2024-03-01 | 2025-06-27 |
| MSC-EV in Acute-on-Chronic Liver Failure After Liver Transplantation MSC-EV - Liver Failure, Acute on Chronic | Phase 1 | Withdrawn | Third Affiliated Hospital, Sun Yat-Sen University | 2023-09-30 | 2023-10-12 | |
| Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure standard medical treatment, Placebo, hUC-MSC - Acute-On-Chronic Liver Failure | Phase 1 / Phase 2 | Recruiting | Beijing 302 Hospital | 150 | 2023-09-30 | 2024-05-07 |
| The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver Failure MSC-EVs - Acute-On-Chronic Liver Failure, Acute Liver Failure | Phase 1 / Phase 2 | Withdrawn | Third Affiliated Hospital, Sun Yat-Sen University | 2023-09-01 | 2023-10-12 | |
| Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients Bone marrow mesenchymal stem cells (low dose), Solvent of CG-BM1, Bone marrow mesenchymal stem cells (medium dose) - Acute-On-Chronic Liver Failure | Phase 1 / Phase 2 | Completed | GuangZhou Cellgenes Biotechnology Co., Ltd. | 100 | 2023-03-01 | 2026-10-21 |
| Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF) Branch Chain Amino Acid, Lactulose - Hepatic Encephalopathy, Acute-On-Chronic Liver Failure | Phase 1 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 114 | 2023-01-17 | 2025-06-08 |
| Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF Branched chain amino acid, Lactulose - Hepatic Encephalopathy, Acute-On-Chronic Liver Failure | Phase 1 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 70 | 2019-11-01 | 2022-08-16 |
| Safety and Efficacy of Mesenchymal Stem Cell Transplantation for Acute-on-Chronic Liver Failure Mesenchymal Stem Cell - Liver Failure, Acute on Chronic | Phase 1 / Phase 2 | Unknown | Tianjin Weikai Bioeng., Ltd. | 45 | 2019-10-01 | 2019-03-20 |
| Allogeneic ABCB5-positive Stem Cells for Treatment of Acute-on-Chronic Liver Failure allo-APZ2-ACLF - Acute-On-Chronic Liver Failure | Phase 1 / Phase 2 | Terminated | RHEACELL GmbH & Co. KG | 5 | 2019-03-22 | 2021-11-17 |
| TRimetazidine for acUte on Chronic Liver Failure STudy Trimetazidine - Acute-On-Chronic Liver Failure | Phase 1 | Suspended | Martin Pharmaceuticals | 30 | 2018-11-28 | 2021-03-04 |
| Safety Study of Stemchymal® in Acute Liver Failure Stemchymal® - Stem Cells, Adult Stem Cells | Phase 1 | Withdrawn | Steminent Biotherapeutics Inc. | 2018-10-01 | 2022-10-28 | |
| Single Pass Albumin Dialysis in Patients With Cirrhosis Single pass albumin dialysis - Cirrhosis, Acute on Chronic Hepatic Failure | Phase 1 / Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 11 | 2009-06-01 | 2015-02-25 |
Hepatic Encephalopathy (3) · Liver Failure, Acute (3) · Brain Diseases (1) · Brain Edema (1) · Chemical and Drug Induced Liver Injury (1) · End Stage Liver Disease (1) · Fibrosis (1) · Hepatorenal Syndrome (1) · Liver Failure (1)
Digestive System Diseases (17) · Hepatic Insufficiency (17) · Liver Diseases (17) · Liver Failure (16) · Liver Failure, Acute (14) · Central Nervous System Diseases (4) · Nervous System Diseases (4) · Brain Diseases (3) · Brain Diseases, Metabolic (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Chemically-Induced Disorders (1) · Drug-Related Side Effects and Adverse Reactions (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1)
Lactulose (2) · Amino Acids (1) · Amino Acids, Branched-Chain (1) · Drug Delivery Systems (1) · Trimetazidine (1)
Third Affiliated Hospital, Sun Yat-Sen University (3) · Post Graduate Institute of Medical Education and Research, Chandigarh (2) · Assistance Publique - Hôpitaux de Paris (1) · Beijing 302 Hospital (1) · Genfit (1) · GuangZhou Cellgenes Biotechnology Co., Ltd. (1) · Institute of Liver and Biliary Sciences, India (1) · Martin Pharmaceuticals (1) · Miromatrix Medical Inc. (1) · RHEACELL GmbH & Co. KG (1) · RenJi Hospital (1) · Steminent Biotherapeutics Inc. (1) · Tianjin Weikai Bioeng., Ltd. (1) · eGenesis, INC (1)
China (7) · United States (3) · France (2) · Germany (2) · India (2) · Austria (1) · Belgium (1) · Spain (1) · Taiwan (1)
Dr. Shiv Kumar Sarin, DM (1) · Jack Lake, MD (1) · Madhumita Premkumar, MD, DM (1) · Matthias Ebert, Prof. Dr. (1) · Ming Shi, PhD (1) · Yang Yang, PHD, MD (1)
PMID 25715177, PMID 30568347, PMID 33011075, PMID 37975059, PMID 38925694, PMID 40233953, PMID 6749458, PMID 818729