155 completed, 13 unknown, 7 terminated, 4 recruiting. 53 Phase 3, 48 Phase 2, 31 Phase 1, 23 Not applicable, 21 Phase 4.
Follow Actinic Keratosis: new trials by email Literature Review of Actinic Keratosis trials Research Report on Actinic Keratosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Therapeutic Induction of Dermal Remodeling in Veterans to Prevent Actinic Neoplasia Caused by Chronic Environmental Exposure to Ultraviolet Radiation Microneedling, Trichloroacetic acid peel - Nonmelanoma Skin Cancer, Actinic Keratosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 96 | 2026-11-01 | 2026-10-06 |
| A Phase 2 Study of HW211026 HW211026 - Actinic Keratosis | Phase 2 | Not yet recruiting | Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. | 80 | 2026-07-01 | 2026-07-09 |
| Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities Reformulated Levulan Kerastick containing aminolevulinic acid hydrochloride (ALA HCl), 20%, Vehicle, Blue Light Photodynamic Therapy Illuminator device, BLU-U® model 4170E. - Actinic Keratosis | Phase 3 | Recruiting | Sun Pharmaceutical Industries, Inc. | 260 | 2025-11-29 | 2026-04-22 |
| Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp Reformulated Levulan Kerastick containing aminolevulinic acid hydrochloride (ALA HCl), 20%, Vehicle containing excipients only (VEH) without active ingredient, Blue Light Photodynamic Therapy Illuminator device, BLU-U® model 4170E - Actinic Keratosis | Phase 3 | Recruiting | Sun Pharmaceutical Industries, Inc. | 160 | 2025-11-19 | 2026-04-22 |
| The Effect of Topical Imipramine on Photodynamic Therapy-Mediated Immunosuppression on Forearms or Face on US Veterans Imipramine, Control Vehicle - Actinic Keratosis, Imipramine | Phase 2 | Recruiting | VA Office of Research and Development | 48 | 2025-04-01 | 2025-12-22 |
| Trial to Investigate GZ21T in Healthy Volunteers GZ21T - Actinic Keratosis | Phase 1 | Completed | Genzada Pharmaceuticals USA, Inc. | 41 | 2024-08-19 | 2026-01-28 |
| Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients Biopsy, Calcipotriene, Fluorouracil - Actinic Keratosis | Phase 2 | Active not recruiting | University of Arizona | 56 | 2024-07-02 | 2025-09-24 |
| Study on the Safety and Efficacy of Bimiralisib Gel in Participants Suffering From Actinic Keratosis Bimiralisib - Actinic Keratosis | Phase 2 | Completed | TORQUR | 46 | 2024-04-02 | 2025-07-18 |
| Short Contact Protocols to Reduce Pain During 10% ALA Gel Red-light Photodynamic Therapy of Actinic Keratoses Topical aminolevulinate (10% ALA gel), Red light illumination - Actinic Keratosis | Phase 2 | Completed | Case Comprehensive Cancer Center | 30 | 2023-10-02 | 2025-10-23 |
| Tirbanibulin 1% Ointment for the Treatment of Chronically Sun-damaged Skin on the Face Tirbanibulin - Actinic Keratosis | Phase 4 | Completed | Medical University of Graz | 22 | 2023-05-11 | 2023-11-14 |
| A Study of Tirbanibulin on the Wellbeing of Participants With Actinic Keratoses Tirbanibulin 2.5 mg ointment - Actinic Keratosis | Phase 4 | Completed | Almirall, S.A. | 334 | 2023-01-20 | 2025-02-20 |
| The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy Imipramine, Vehicle - Imipramine, Photodynamic Therapy | Phase 1 | Recruiting | Wright State University | 24 | 2023-01-19 | 2026-08-20 |
| MRB 0.3% Serum Effectiveness on 2 Early Clinical Markers of Photoinduced Cutaneous Aging: Actinic Lentigo and Actinic Keratosis Topical application of MRB 0.3% serum and placebo serum (hemi face or skull) - Actinic Keratosis, Actinic Lentigo | Not applicable | Unknown | NAOS Institute of Life Science | 35 | 2022-01-01 | 2021-12-30 |
| A Multi-Center Study to Evaluate the Efficacy and Safety of KX01 Ointment 1% on Actinic Keratosis on Face or Scalp KX01 ointment 1%, Placebo - Actinic Keratosis | Phase 3 | Completed | PharmaEssentia | 108 | 2021-12-21 | 2024-04-19 |
| Study to Evaluate Safety and Tolerability of BF-200 ALA (Ameluz®) for Photodynamic Therapy in the Treatment of the Expanded Field of Actinic Keratosis on Face and Scalp BF-200 ALA and red light LED lamp - Actinic Keratosis, Keratosis, Actinic | Phase 1 | Completed | Biofrontera Bioscience GmbH | 112 | 2021-12-01 | 2024-10-17 |
| Pain Management During a Photodynamic Therapy Session on the Vertex for Actinic Keratosis: Tumescent Anesthesia Interest Procedure (Tumesent anesthesia), Control Arm (Paracetamol) - Pain, Actinic Keratosis | Not applicable | Unknown | Poitiers University Hospital | 48 | 2021-07-28 | 2021-09-29 |
| Daylight Photodynamic Therapy for the Treatment of Actinic Keratoses in the Northeast United States aminolevulinic acid HCl - Actinic Keratosis, Non-melanoma Skin Cancer | Not applicable | Withdrawn | Brigham and Women's Hospital | 2020-12-01 | 2021-02-01 | |
| 5% KOH Solution vs. Placebo and Diclofenac Gel for the Treatment of Actinic Keratosis Solcera, Placebo, Solaraze - Actinic Keratosis | Phase 3 | Completed | Infectopharm Arzneimittel GmbH | 631 | 2020-10-14 | 2024-03-05 |
| Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Actinic Keratosis Aminolevulinic acid photodynamic therapy - Actinic Keratosis | Not applicable | Unknown | Shanghai Dermatology Hospital | 10 | 2020-05-01 | 2020-05-20 |
| Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic Keratoses Photodynamic therapy (PDT), Vitamin D3 - Actinic Keratosis | Phase 2 | Completed | Case Comprehensive Cancer Center | 75 | 2020-01-13 | 2022-06-24 |
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Keratosis, Actinic (186) · Skin Diseases (6) · Carcinoma, Squamous Cell (5) · Keratosis (5) · Precancerous Conditions (5) · Carcinoma, Basal Cell (4) · Skin Neoplasms (4) · Bowen's Disease (3) · Melanosis (3) · Warts (3) · Molluscum Contagiosum (2) · Rosacea (2) · Tinea (2) · Acne Vulgaris (1) · Agnosia (1)
Skin and Connective Tissue Diseases (186) · Neoplasms (185) · Keratosis (181) · Precancerous Conditions (181) · Skin Diseases (180) · Neoplasms by Histologic Type (10) · Carcinoma (9) · Neoplasms, Glandular and Epithelial (9) · Neoplasms, Squamous Cell (7) · Neoplasms by Site (5) · Neoplasms, Basal Cell (4) · Pigmentation Disorders (4) · DNA Virus Infections (3) · Hyperpigmentation (3) · Infections (3)
3-ingenyl angelate (32) · Aminolevulinic Acid (19) · Imiquimod (16) · Photochemotherapy (10) · Cryotherapy (8) · Fluorouracil (8) · Diclofenac (7) · Gels (6) · Solutions (6) · methyl 5-aminolevulinate (6) · LEO 43204 (5) · BF-200 ALA (4) · Ointments (3) · Cryosurgery (2) · Imipramine (2)
LEO Pharma (29) · Peplin (15) · Almirall, S.A. (8) · DUSA Pharmaceuticals, Inc. (6) · Actavis Inc. (5) · Biofrontera Bioscience GmbH (5) · G&E Herbal Biotechnology Co., LTD (5) · Galderma R&D (5) · Sun Pharmaceutical Industries, Inc. (5) · MEDA Pharma GmbH & Co. KG (4) · Dong-A University (3) · Graceway Pharmaceuticals, LLC (3) · Icahn School of Medicine at Mount Sinai (3) · The Cleveland Clinic (3) · University of California, Davis (3)
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Stuart Marcus, MD, PhD (6) · C. William Hanke, MD (3) · Eugene Bauer, MD (3) · Daniel M Siegel, MD (2) · Edward Maytin, MD, PhD (2) · Gary Goldenberg, MD (2) · Jane Fang, MD (2) · Jonothan S Dosik, MD (2) · Lars E French, MD (2) · Luis A Torezan, MD (2) · Rolf-Markus Szeimies, Prof Dr (2) · Steve Feldman, MD, PhD (2) · Alberto Lecchi (1)
PMID 23553119, PMID 22417254, PMID 38125671, PMID 24765228, PMID 25584134, PMID 33196758, PMID 35314199, PMID 10607349, PMID 11493098, PMID 11966728, PMID 12533168, PMID 15097955, PMID 15168956, PMID 17822489, PMID 18067627, PMID 18955209, PMID 19221274, PMID 19467365, PMID 20231500, PMID 20514316, PMID 20518784, PMID 20725550, PMID 21753882, PMID 22055282, PMID 22527424, PMID 22714759, PMID 23252768, PMID 23510990, PMID 23815349, PMID 24068130, PMID 24509965, PMID 24672213, PMID 24892649, PMID 24918567, PMID 25257941, PMID 25640401, PMID 25727104, PMID 26300464, PMID 27612149, PMID 27869649, PMID 27995485, PMID 28264612, PMID 28905294, PMID 28979661, PMID 29204958, PMID 29399258, PMID 29399263, PMID 30329163, PMID 31407414, PMID 33567191
2014 (2), 2015 (2), 2005 (1), 2017 (1), P30CA023074 (1), R21CA156227 (1), UG1CA242596 (1)