10 completed, 5 unknown, 1 not yet recruiting, 1 no longer available. 7 Not applicable, 4 Phase 2, 3 Phase 1, 2 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Unknown 4, Completed 2, Not yet recruiting 1 |
| Phase 2 | 4 | Completed 3, Unknown 1 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
Follow Bowen's Disease: new trials by email Literature Review of Bowen's Disease trials Research Report on Bowen's Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease in Adults High Intensity Focused Ultrasound, Cryotherapy - Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma | Not applicable | Not yet recruiting | Jussi Salonen | 294 | 2026-04-01 | 2026-02-03 |
| OCT and Invasion in Cutaneous Skin Lesions Optical Coherence Tomography, Clinical assessment - Cutaneous Squamous Cell Carcinoma, Bowen's Disease | Completed | Maastricht University Medical Center | 71 | 2023-03-01 | 2025-04-04 | |
| Clinical vAlidation of a MobilE appLication ("ProRodinki") in the Assessment of the maLignant skIn neoplAsms Mobile phone application "ProRodinki" - Melanoma (Skin), Nevus | Not applicable | Unknown | MelanomaPRO, Russia | 605 | 2022-04-23 | 2022-06-02 |
| Research of Laser Ablation for the Treatment of Lower Anogenital Tracts' Precancerous Lesions laser ablation - Squamous Intraepithelial Lesions, Laser Burn | Not applicable | Unknown | Tongji Hospital | 200 | 2019-11-08 | 2021-12-28 |
| Surgical Excision Versus Photodynamic Therapy and Topical 5-fluorouracil in Treatment of Bowen's Disease Methyl Aminolevulinate (Mal) for Topical Administration, 16.8%, 1 Gram, 5Fluorouracil, Surgical excision - Bowen's Disease | Phase 4 | Completed | Maastricht University Medical Center | 250 | 2019-05-27 | 2025-05-06 |
| Open Label, Dose Escalation Study for the Safety and Efficacy of STP705 in Adult Patients With isSCC STP705 - Bowen's Disease, Cutaneous Squamous Cell Carcinoma in Situ | Phase 1 / Phase 2 | Completed | Sirnaomics | 25 | 2019-03-21 | 2022-06-09 |
| Photographing the Skin During Photodynamic Therapy Fluorescence and thermal imaging - Basal Cell Carcinoma, Bowen's Disease | Not applicable | Completed | University of Dundee | 18 | 2017-06-22 | 2021-07-16 |
| Using a Cold Atmospheric Plasma Device to Treat Skin Disorders Non-thermal, atmospheric plasma to treat skin lesions and acne, Indirect non-thermal, atmospheric plasma to treat hair loss and acne - Actinic Keratosis, Acne/Rosacea | Not applicable | Unknown | The Skin Center Dermatology Group | 100 | 2016-01-01 | 2022-04-12 |
| Laser Assisted Drug Delivery in the Treatment of Superficial Non Melanoma Skin Cancer: a Randomized Controlled Trial full ablative CO2 laser, fractional ablative CO2 laser, MAL - Bowen's Disease, Superficial Basal Cell Carcinoma | Not applicable | Completed | University Hospital, Ghent | 16 | 2014-09-01 | 2018-01-25 |
| Long-term Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy for Treatment of Lower Extremity Bowen's Disease lidocaine-prilocaine 5% cream application, 2940-nm Er:YAG AFL pretreatment, methyl-aminolevulinate application - Bowen's Disease | Phase 1 | Completed | Dong-A University | 60 | 2011-10-30 | 2017-10-25 |
| Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Bowen's Disease Er:YAG AFL-PDT, MAL-PDT - Bowen's Disease | Phase 1 | Completed | Dong-A University | 21 | 2011-03-01 | 2013-08-01 |
| Clinical Study Assessment of SR-T100 Topical Gel Against Actinic Keratosis SR-T100 ® Gel - Actinic Keratosis, Bowen's Disease | Phase 2 | Completed | G&E Herbal Biotechnology Co., LTD | 27 | 2007-11-01 | 2014-03-14 |
| Trial of Excision Versus Photodynamic Therapy in the Treatment of Bowen's Disease excision, Photodynamic therapy - Bowen's Disease | Phase 4 | Terminated | Catharina Ziekenhuis Eindhoven | 65 | 2007-05-01 | 2010-05-13 |
| Topical Imiquimod for Bowen's Disease of the Head and Neck Imiquimod - Bowens Disease | Phase 2 / Phase 3 | Unknown | Brooke Army Medical Center | 50 | 2006-11-01 | 2008-03-26 |
| Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Cutaneous Squamous Cell Carcinoma In Situ PEP005 - Carcinoma, Squamous Cell | Phase 2 | Completed | Peplin | 24 | 2006-05-01 | 2015-01-19 |
| Effects of Arsenic on Keratinocytes in a Skin Equivalent Model foreskin from healthy adults for organotypic culture - Bowen Disease | Not applicable | Unknown | National Taiwan University Hospital | 20 | 2005-06-01 | 2005-12-21 |
| Photodynamic Therapy (PDT) With Metvix® 160 Milligrams/Gram Cream in Organ Transplant Participants With Non-melanoma Skin Cancer Photodynamic therapy with Metvix 160 mg/g cream - Actinic Keratosis, Warts | Phase 3 | Completed | Galderma R&D | 82 | 2003-07-25 | 2025-04-18 |
| Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease Metvix (methyl aminolevulinate) - Field Actinic Keratoses, Basal Cell Carcinoma | No longer available | Galderma R&D | 2021-02-18 |
Carcinoma, Basal Cell (5) · Keratosis, Actinic (4) · Carcinoma, Squamous Cell (3) · Warts (2) · Carcinoma (1) · Disease (1) · Keratosis (1) · Melanoma (1) · Molluscum Contagiosum (1) · Nevus (1) · Nevus, Epithelioid and Spindle Cell (1) · Nevus, Halo (1) · Nevus, Pigmented (1) · Rosacea (1)
Neoplasms (18) · Neoplasms by Histologic Type (18) · Neoplasms, Glandular and Epithelial (18) · Neoplasms, Squamous Cell (18) · Carcinoma (17) · Carcinoma, Squamous Cell (15) · Skin Diseases (6) · Skin and Connective Tissue Diseases (6) · Neoplasms, Basal Cell (5) · Precancerous Conditions (5) · Keratosis (4) · DNA Virus Infections (2) · Infections (2) · Papillomavirus Infections (2) · Pathological Conditions, Signs and Symptoms (2)
methyl 5-aminolevulinate (4) · Photochemotherapy (2) · 3-ingenyl angelate (1) · Anesthesia, Local (1) · Cryotherapy (1) · Epinephrine (1) · Fluorouracil (1) · Imiquimod (1) · Laser Therapy (1) · Lidocaine (1) · Lidocaine, Prilocaine Drug Combination (1) · Microphysiological Systems (1) · Myelin and Lymphocyte-Associated Proteolipid Proteins (1) · SR-T100 (1) · Tomography, Optical Coherence (1)
Dong-A University (2) · Galderma R&D (2) · Maastricht University Medical Center (2) · Brooke Army Medical Center (1) · Catharina Ziekenhuis Eindhoven (1) · G&E Herbal Biotechnology Co., LTD (1) · Jussi Salonen (1) · MelanomaPRO, Russia (1) · National Taiwan University Hospital (1) · Peplin (1) · Sirnaomics (1) · The Skin Center Dermatology Group (1) · Tongji Hospital (1) · University Hospital, Ghent (1) · University of Dundee (1)
United States (3) · Netherlands (2) · Taiwan (2) · United Kingdom (2) · Australia (1) · Belgium (1) · China (1) · Denmark (1) · Finland (1) · Germany (1) · Norway (1) · Russia (1) · South Korea (1) · Sweden (1)
Ann-Marie Wennberg, MD, PhD (1) · Annette Verzijl, MD (1) · Barbara Boone, MD PhD (1) · Brian Berman, MD, PhD (1) · Dr. Hamm-Ming Sheu, MD (1) · Hsin-Su Yu, MD PHD (1) · Igor V Samoylenko (1) · K Mosterd, MD, PhD (1) · Ki-Hoon Song, M.D., Ph.D. (1) · Klara Mosterd, Professor (1) · Kush Dhody, MBBS, MS, CCRA (1) · Lev V Demidov, Professor (1) · Nicole M Owens, MD (1) · Robert Rosen, Dr. (1) · Sari Koskenmies, Head of Department (1)
PMID 26467274, PMID 32889812, PMID 35491738, PMID 36302167, PMID 40934140, PMID 41391634