63 completed, 9 unknown, 6 active not recruiting, 6 terminated. 27 Not applicable, 17 Phase 4, 16 Phase 3, 14 Phase 2, 12 Phase 1.
Follow Actinic Keratoses: new trials by email Literature Review of Actinic Keratoses trials Research Report on Actinic Keratoses
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and Forehead Cryotherapy + Tirbanibulin - Keratosis, Actinic Keratoses | Phase 3 | Not yet recruiting | University Hospital, Lille | 59 | 2026-11-30 | 2026-05-22 |
| 5-Fluorouracil and Calcipotriene for Field Treatment of Actinic Keratoses Combination field therapy with 5-fluorouracil and calcipotriene (5FU/C) - Actinic Keratoses | Phase 1 | Not yet recruiting | Cedars-Sinai Medical Center | 96 | 2026-09-01 | 2026-10-05 |
| PDT vs Peels for Treatment of Actinic Keratoses Photodynamic Therapy, Chemical Peels - Actinic Keratoses | Phase 2 | Not yet recruiting | Northwestern University | 60 | 2026-08-01 | 2026-07-01 |
| Actinic Keratoses Treated With 5-fluorouracil Plus Aluminum 5% 5-fluorouracil (5-FU) powder, 5% 5-fluorouracil (5-FU) powder PLUS 15% Aluminum Chloride Hexahydrate (ACH) - Actinic Keratoses | Phase 1 | Recruiting | West Virginia University | 32 | 2026-02-06 | 2026-04-22 |
| Immunotherapy After Transplantation for Skin Cancer Prevention in Organ Transplant Recipients Calcipotriol Only Product in Cutaneous Dose Form, Vaseline, Topical 5FU - Immunotherapy, Cutaneous Squamous Cell Carcinoma | Phase 2 | Withdrawn | Massachusetts General Hospital | 2026-01-01 | 2025-05-07 | |
| Immunotherapy Before Transplantation for Skin Cancer Prevention in Organ Transplant Recipients Calcipotriol Only Product in Cutaneous Dose Form, Vaseline, Topical 5FU - Cutaneous Squamous Cell Carcinoma, Actinic Keratoses | Phase 2 | Withdrawn | Massachusetts General Hospital | 2026-01-01 | 2025-05-07 | |
| Activation of Ameluz With BBL HEROic for the Treatment of Actinic Keratoses and Photodamage Ameluz, Sciton HEROic - Actinic Keratoses, Photodamage | Phase 1 | Completed | Sherrif Ibrahim | 10 | 2025-06-27 | 2026-01-02 |
| Efficacy of Topical 5-Fluorouracil Vs Calcipotriol As Photodynamic Therapy Pre-treatment for Field Actinic Keratoses 5-FU (fluorouracil), Calcipotriol - Actinic Keratosis of Face and Scalp, Actinic Keratoses | Not applicable | Not yet recruiting | St Vincent's University Hospital, Ireland | 50 | 2025-01-01 | 2024-11-12 |
| Methyl Aminolevulinate 8% and 16% Incubated by 1 and 3 for Actinic Keratoses Treatment light curettage, Pre irradiation of 1 hour, Pre irradiation of 3 hour - Actinic Keratoses | Not applicable | Completed | University of Nove de Julho | 4 | 2024-11-30 | 2026-07-29 |
| Combination Therapy of 5-Fluorouracil and CALcipotriol Versus 5-Fluorouracil in the Treatment of Actinic Keratosis 5FU-Calcipotriol, 5-FU 50 MG/ML Topical Cream - Actinic Keratoses | Phase 4 | Completed | Maastricht University Medical Center | 232 | 2024-09-04 | 2026-10-29 |
| Imaging Techniques to Monitor Photosensitizer and sO2 Levels During Photodynamic Therapy of Actinic Keratoses Topical Aminolevulinate, Photodynamic therapy (PDT), Red light illumination - Actinic Keratoses | Phase 2 | Completed | Case Comprehensive Cancer Center | 14 | 2024-08-25 | 2026-02-20 |
| Efficacy And Safety Of Illumination Dose Reduction In Red Light Photodynamic Therapy For Actinic Keratoses Half-dose illumination protocol, Full-dose illumination protocol - Actinic Keratoses | Not applicable | Unknown | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 20 | 2024-08-01 | 2024-08-09 |
| Efficacy and Safety of Cryotherapy Versus 5-Fluorouracil in the Treatment of Actinic Keratosis Cryotherapy, 5Fluorouracil - Actinic Keratoses | Phase 4 | Enrolling by invitation | University of California, Davis | 73 | 2024-07-01 | 2026-07-06 |
| Evaluating an Artificial Intelligence Tool to Help Primary Care Doctors Diagnose Skin Conditions. AI-based medical device for aided diagnosis in dermatological conditions - Skin Lesions, Melanocytic Nevi | Completed | AI Labs Group S.L | 9 | 2024-06-04 | 2026-02-24 | |
| Investigation of the Effect of Lipikar Baume AP+M Lipikar Baume AP+M - Actinic Keratoses | Not applicable | Recruiting | CentroDerm GmbH | 20 | 2024-04-23 | 2025-07-11 |
| Effect of Lipikar Urea 30% Before Actinic Keratoses Treatment Group A: holistic approach, Group B: Tolak® Standard of use - Actinic Keratoses | Not applicable | Unknown | Cosmetique Active International | 100 | 2024-04-05 | 2024-06-18 |
| The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population Fractionated Laser Resurfacing - Actinic Keratoses, Aging | Not applicable | Recruiting | Wright State University | 80 | 2024-03-20 | 2026-07-16 |
| SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography OCT (Optical Coherence Tomography) - Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder | Recruiting | University of Palermo | 200 | 2024-03-13 | 2025-05-23 | |
| Tirbanibulin 1% Ointment for the Treatment of Actinic Keratosis on the Back of the Hands Tirbanibulin - Actinic Keratoses | Phase 4 | Withdrawn | Medical University of Graz | 2023-10-01 | 2024-05-30 | |
| Impact of Madecassoside and 5 % Panthenol Cream in Post Photodynamic Therapy for Actinic Keratosis Cream containing madecassoside and 5 % panthenol, Daylight PDT - Actinic Keratoses | Not applicable | Completed | Merete Haedersdal | 20 | 2023-09-27 | 2024-05-08 |
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Keratosis, Actinic (98) · Carcinoma, Squamous Cell (8) · Carcinoma, Basal Cell (4) · Skin Diseases (4) · Skin Neoplasms (4) · Melanoma (3) · Keratosis (2) · Precancerous Conditions (2) · Actinic cheilitis (1) · Bowen's Disease (1) · Disease (1) · Graft vs Host Disease (1) · Health Behavior (1) · Hidradenitis Suppurativa (1) · Leukoplakia, Oral (1)
Skin and Connective Tissue Diseases (98) · Neoplasms (97) · Keratosis (96) · Precancerous Conditions (96) · Skin Diseases (94) · Neoplasms by Histologic Type (12) · Carcinoma (11) · Neoplasms, Glandular and Epithelial (11) · Neoplasms, Squamous Cell (9) · Neoplasms by Site (8) · Neoplasms, Basal Cell (4) · Neoplasms, Germ Cell and Embryonal (3) · Neoplasms, Nerve Tissue (3) · Neuroectodermal Tumors (3) · Neuroendocrine Tumors (3)
Fluorouracil (13) · Photochemotherapy (10) · Aminolevulinic Acid (9) · Imiquimod (8) · methyl 5-aminolevulinate (8) · 3-ingenyl angelate (5) · Cryotherapy (4) · Gels (4) · Petrolatum (4) · calcipotriene (3) · 1-phenyl-3,3-dimethyltriazene (2) · BF-200 ALA (2) · Diclofenac (2) · Niacinamide (2) · Phototherapy (2)
Maastricht University Medical Center (6) · Galderma R&D (4) · Northwestern University (4) · Peplin (4) · University of California, Davis (3) · Bispebjerg Hospital (2) · Encube Ethicals Pvt. Ltd. (2) · Graceway Pharmaceuticals, LLC (2) · Icahn School of Medicine at Mount Sinai (2) · Massachusetts General Hospital (2) · Medical University of Graz (2) · Merete Haedersdal (2) · Novoxel Ltd. (2) · Shanghai Dermatology Hospital (2) · St Vincent's University Hospital, Ireland (2)
United States (39) · Germany (13) · Netherlands (9) · Denmark (6) · Australia (5) · France (5) · United Kingdom (4) · Austria (3) · Belgium (3) · Italy (3) · Spain (3) · Brazil (2) · China (2) · Israel (2) · Sweden (2)
Klara Mosterd, prof.dr. (4) · Murad Alam, MD (4) · Assi Levi, MD (2) · Janelle Katsamas (2) · Shadmehr Demehri, MD/PHD (2) · Alexandra Geusau, Prof. Dr. (1) · Andrew McGovern, MD (1) · Antonio Martorell, PhD (1) · Barry Galitzer, MD (1) · Bibiana Perez Garcia, MD (1) · Charlotte Proby, MBCHB (1) · Christine M. Winslow, Ph.D. (1) · Claas Ulrich, MD (1) · Claus Garbe, Prof. Dr. (1) · Daniel Eisen, MD (1)
PMID 22417254, PMID 25950503, PMID 17488399, PMID 17488400, PMID 20133013, PMID 21283921, PMID 22136038, PMID 22329784, PMID 24033340, PMID 24037822, PMID 24589500, PMID 24818175, PMID 25124939, PMID 25174261, PMID 25561207, PMID 26011755, PMID 26300464, PMID 26843523, PMID 26921093, PMID 27167413, PMID 27375183, PMID 27453064, PMID 27500794, PMID 27672408, PMID 28489298, PMID 28532759, PMID 29070025, PMID 29427796, PMID 30868672, PMID 30887613, PMID 31334125, PMID 31736123, PMID 31955461, PMID 32387665, PMID 33567191, PMID 34428179, PMID 34633154, PMID 34743007, PMID 36198452, PMID 36232651, PMID 37146674, PMID 38495115, PMID 40047786, PMID 6567734
2016 (1), R44CA250727 (1)