461 completed, 91 terminated, 37 unknown, 37 withdrawn. 233 Phase 2, 152 Phase 4, 121 Not applicable, 120 Phase 3, 63 Phase 1.
Follow Sugar pill: new trials by email Literature Review of Sugar pill trials Research Report on Sugar pill
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a Myelin Repair Therapy Clemastine Fumarate, Placebo - Demyelinating Diseases, Demyelination; Corpus Callosum | Phase 1 / Phase 2 | Not yet recruiting | University of California, San Francisco | 44 | 2026-09-15 | 2026-03-11 |
| Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids 2 mL SunButyrate-TG, Placebo, 4 mL SunButyrate-TG - Congenital Heart Disease (CHD) | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 105 | 2026-03-01 | 2026-02-24 |
| Effects of Eszopiclone and Lemborexant in People With OSA With a Low Arousal Threshold Who Have Difficulty Sleeping Eszopiclone 3 mg, Placebo, Lemborexant 10mg - OSA - Obstructive Sleep Apnea | Phase 2 | Recruiting | Flinders University | 15 | 2025-10-31 | 2026-09-02 |
| JAK Signaling in Depression Baricitinib, Placebo - Major Depressive Disorder | Phase 2 | Recruiting | Emory University | 100 | 2025-09-03 | 2026-09-28 |
| Modafinil and Exercise for Post Stroke Fatigue Modafinil 200mg, Placebo, Exercise - Stroke, Fatigue | Phase 3 | Not yet recruiting | University Health Network, Toronto | 212 | 2025-09-01 | 2025-06-10 |
| The Role of Vitamin K on Knee Osteoarthritis Outcomes Vitamin K1 500 µg, K1 1000 µg, Vitamin K2 (MK-7) 300 µg - Osteo Arthritis Knee | Phase 1 / Phase 2 | Active not recruiting | Boston University | 49 | 2025-06-03 | 2026-09-21 |
| Clinical Trial Evaluating the Efficacy of AGB101 for Reducing Hippocampal Overactivity in Older Adults AGB101, Placebo - Hippocampal Overactivity, Dementia | Phase 2 | Active not recruiting | Johns Hopkins University | 60 | 2025-04-17 | 2026-08-31 |
| Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL) Cyclobenzaprine HCl, Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 180 | 2025-03-25 | 2026-10-22 |
| Dexamethasone Use in Pediatric Rhabdomyolysis Patients in Addition to Standard Protocols Dexamethasone, Placebo - Rhabdomyolysis | Phase 1 | Recruiting | Children's National Research Institute | 50 | 2024-10-01 | 2025-07-03 |
| Efficacy of Recombinant Bovine Lactoferrin (rbLf) in Iron Regulation Recombinant Bovine Lactoferrin, Bovine Milk-Derived Lactoferrin, Placebo - Exercise Performance | Not applicable | Completed | University of North Carolina, Chapel Hill | 92 | 2024-07-05 | 2025-09-17 |
| Role Of Sensitivity to neuroEndocrine Systems in Social Decisions Hydrocortisone, Yohimbine, Placebo - Borderline Personality Disorder | Phase 4 | Withdrawn | University of North Carolina, Chapel Hill | 2024-07-01 | 2024-06-05 | |
| An Exploratory Clinical Study of Statins for Improving Chemotherapy and Maintenance in Patients With Ovarian Cancer Statin, Sugar pill - Ovarian Cancer | Phase 2 | Unknown | Anhui Provincial Cancer Hospital | 500 | 2024-06-30 | 2024-06-21 |
| MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction MitoQ, Placebo - Schizophrenia and Related Disorders, Mitochondrial Alteration | Phase 2 / Phase 3 | Recruiting | Mclean Hospital | 100 | 2024-06-01 | 2025-09-25 |
| Beta-Blocker Influences on Inflammatory and Neural Responses to Stress Propranolol, Placebo - Cardiovascular Disease | Phase 4 | Recruiting | University of North Carolina, Chapel Hill | 120 | 2024-05-01 | 2025-10-29 |
| The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study Finerenone Oral Tablet, Placebo - Kidney Transplant; Complications | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 100 | 2024-04-23 | 2026-04-14 |
| Study of LAU-7b for the Treatment of Long COVID in Adults LAU-7b for 3 cycles, LAU-7b for 1 cycle, then placebo, Placebo for 3 cycles - Long COVID | Phase 2 / Phase 3 | Completed | Laurent Pharmaceuticals Inc. | 272 | 2023-11-15 | 2026-01-06 |
| Reboxetine for Sleep Apnoea After ENT Surgery Reboxetine 4 MG Oral Tablet, Placebo - Sleep Apnea, Obstructive | Phase 2 | Recruiting | Flinders University | 20 | 2023-08-10 | 2024-10-03 |
| Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy Clemastine Fumarate, Placebo - Multiple Sclerosis (MS), Multiple Sclerosis, Relapsing-Remitting | Phase 1 / Phase 2 | Recruiting | University of California, San Francisco | 74 | 2023-08-01 | 2026-07-02 |
| The Effect of NAD Supplementation on Brain Vascular Health in Aging Nicotinamide riboside, Placebo - Aging | Phase 4 | Recruiting | University of Oklahoma | 214 | 2023-05-03 | 2026-04-01 |
| A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults with Long COVID. Nirmatrelvir, Ritonavir, Placebo - Long COVID | Phase 2 | Completed | Harlan M Krumholz | 100 | 2023-04-14 | 2024-12-02 |
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Mehmet Sofuoglu, M.D., Ph.D. (6) · Barbara J. Mason, Ph.D. (4) · Mehmet Sofuoglu, M.D.,Ph.D. (4) · Bankole Johnson, DSc, MD, PhD (3) · Hugh Brent Solvason (3) · Jon E Grant, JD, MD, MPH (3) · Peter N Schlegel, MD (3) · Richard De La Garza, II, PhD (3) · Robin Kroll, MD (3) · Adam Wanner, MD (2) · Anthony A Bavry, MD, MPH (2) · Apkar Apkarian, PhD (2) · Apkar V Apkarian, PhD (2) · Arthur Waldbaum, MD (2)
PMID 37142273, PMID 34611902, PMID 21849262, PMID 24045678, PMID 24552977, PMID 25137243, PMID 29065885, PMID 29444682, PMID 34229290, PMID 34433773, PMID 36130734, PMID 36999619, PMID 37230961, PMID 10598635, PMID 10816186, PMID 12112073, PMID 12670812, PMID 15275765, PMID 15692967, PMID 16324089, PMID 16414336, PMID 16679671, PMID 16790698, PMID 17194267, PMID 17251278, PMID 17469162, PMID 17485423, PMID 17668979, PMID 17716312, PMID 17716313, PMID 17717203, PMID 17901414, PMID 18174456, PMID 18251624, PMID 18641099, PMID 18672990, PMID 18700421, PMID 19023036, PMID 19155011, PMID 19167733, PMID 19489872, PMID 19577749, PMID 19693492, PMID 19776222, PMID 19892673, PMID 20092966, PMID 20151804, PMID 20155590, PMID 20213818, PMID 20303474
P50DA018197 (5), P50DA018185 (3), R01AA012602 (3), R01CA026582 (3), R01DA014537 (3), 2009 (2), 2015 (2), K01AA026005 (2), P01HL095491 (2), R01AA010522 (2), R01AT007987 (2), R01DA021264 (2), R01DA027134 (2), R01DE022746 (2), R01MH072383 (2)