33 completed, 24 unknown, 8 withdrawn, 3 terminated. 75 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 75 | Completed 33, Unknown 24, Withdrawn 8, Terminated 3, Active not recruiting 2, Not yet recruiting 2, Enrolling by invitation 1, Recruiting 1, Suspended 1 |
Follow Spironolactone: new trials by email Literature Review of Spironolactone trials Research Report on Spironolactone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy Spironolactone (drug), Candesartan 8mg, Hydrochlorothiazide (HCTZ) 25 milligrams. - Hypertension | Phase 4 | Not yet recruiting | Ottawa Hospital Research Institute | 30 | 2027-01-01 | 2026-10-14 |
| Spironolactone Alternate Dosing vs Finerenone in Elevated Potassium - K Safety Study Finerenone, Spironolactone (drug) - Heart Failure, Diabetic Kidney Disease | Phase 4 | Not yet recruiting | Hospital de Messejana Dr. Carlos Alberto Studart Gomes | 60 | 2026-04-01 | 2026-05-13 |
| Unmitigated Aldosterone Signaling During Standard Clinical MRA Dosing Placebo, Spironolactone 25mg, Aldosterone - Heart Failure | Phase 4 | Active not recruiting | Yale University | 21 | 2026-01-27 | 2026-08-26 |
| Statin Combined with Amlodipine Treats Primary Aldosteronism Simvastatin combined with Amlodipine besylate, Simvastatin combined with Spironolactone and Amlodipine besylate., Amlodipine besylate combined Spironolactone - Primary Aldosteronism, Statin | Phase 4 | Recruiting | Third Military Medical University | 180 | 2024-09-10 | 2024-11-22 |
| Low-Dose Spironolactone in Hemodialysis Patients With Resistant Hypertension Spironolactone - Resistant Hypertension, Kidney Failure, Chronic | Phase 4 | Completed | Universitas Sebelas Maret | 21 | 2024-08-20 | 2026-10-22 |
| Finerenone for Patients With Primary Aldosteronism (FAIRY) Finerenone Oral Tablet, Spironolactone Oral Tablet - Primary Aldosteronism | Phase 4 | Completed | Chongqing Medical University | 306 | 2024-06-04 | 2026-09-25 |
| Determination of Drug Levels for Pharmacotherapy of Heart Failure Nebivolol, Valsartan and Sacubitril, Carvedilol - Cardiovascular Diseases, Heart Failure With Reduced Ejection Fraction | Phase 4 | Unknown | University Hospital Ostrava | 100 | 2024-03-01 | 2024-01-18 |
| Efficacy and Safety of Finerenone vs. Spironolactone in Patients With Primary Aldosteronism Finerenone, Spironolactone - Primary Aldosteronism | Phase 4 | Unknown | Shanghai Jiao Tong University School of Medicine | 150 | 2023-12-16 | 2023-12-11 |
| Optimal Medical Treatment of Difficult-to-treat Hypertension Phase C: Eplerenone, Phase C: Spironolactone, Phase C: Torasemide - Hypertension | Phase 4 | Unknown | National Institute of Cardiology, Warsaw, Poland | 2500 | 2023-10-20 | 2024-02-23 |
| Effect of Spironolactone in the Prevention of Anthracycline-induced Cardiotoxicity (SPIROTOX) Spironolactone, Placebo - Cardiotoxicity, Neoplasms | Phase 4 | Unknown | University of Sao Paulo | 264 | 2023-10-01 | 2023-08-22 |
| Comparing the Efficacy and Safety of Finerenone and Spironolactone in the Treatment of Primary Aldosteronism Finerenone, Spironolactone - Primary Aldosteronism, Hypertension | Phase 4 | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 96 | 2023-05-01 | 2023-04-18 |
| Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Dementia Spironolactone, Placebo - Mild Cognitive Impairment, Alzheimer Disease | Phase 4 | Completed | Emory University | 25 | 2022-09-06 | 2026-10-30 |
| Non-Responsive Diabetic Macular Edema and Spironolactone Spironolactone 50 mg - Diabetic Maculopathy | Phase 4 | Withdrawn | Wake Forest University Health Sciences | 2022-07-01 | 2022-08-02 | |
| Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne Spironolactone, Doxycycline Hyclate - Acne | Phase 4 | Active not recruiting | University of Pennsylvania | 350 | 2022-03-30 | 2026-08-25 |
| Spironolactone to Improve Apnea and Cardiovascular Markers in Obstructive Sleep Apnea Patients Spironolactone, Placebo - Obstructive Sleep Apnea | Phase 4 | Withdrawn | University of Michigan | 2022-03-01 | 2022-04-19 | |
| Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone Sodium zirconium cyclosilicate, Placebo, Spironolactone - Hyperkalaemia, Heart Failure With Reduced Ejection Fraction | Phase 4 | Completed | AstraZeneca | 366 | 2021-03-08 | 2025-07-09 |
| Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension Spironolactone, Amiloride - Resistant Hypertension | Phase 4 | Completed | Yonsei University | 118 | 2020-11-16 | 2024-09-24 |
| A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure Eplerenone, Spironolactone - Systolic Heart Failure | Phase 4 | Enrolling by invitation | Bispebjerg Hospital | 7200 | 2020-11-01 | 2023-02-01 |
| Diuretic and Natriuretic Effect of High-dose Spironolactone in Patients With Acute Heart Failure Spironolactone - Heart Failure Acute, Heart Failure; With Decompensation | Phase 4 | Unknown | Laikο General Hospital, Athens | 50 | 2020-10-20 | 2020-11-10 |
| The Comparison Between Spironolactone and Indapamide Monotherapy or in Combination With Amlodipine to Reduce the Risk of Heart Failure Spironolactone, Indapamide - Hypertension | Phase 4 | Unknown | Shanghai Jiao Tong University School of Medicine | 200 | 2020-09-23 | 2021-12-08 |
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Heart Failure (16) · Hypertension (13) · Kidney Failure, Chronic (7) · Fibrosis (6) · Cardio-Renal Syndrome (5) · Hyperaldosteronism (5) · Hyperkalemia (5) · Renal Insufficiency, Chronic (4) · Diabetic Nephropathies (3) · Hypertension Resistant to Conventional Therapy (3) · Cardiomyopathy, Hypertrophic (2) · Cardiotoxicity (2) · Cardiovascular Diseases (2) · Diabetes Mellitus (2) · Heart Failure, Diastolic (2)
Brigham and Women's Hospital (3) · AstraZeneca (2) · Baylor College of Medicine (2) · Shanghai Jiao Tong University School of Medicine (2) · Steno Diabetes Center Copenhagen (2) · Tottori University Hospital (2) · Universidad de los Andes, Chile (2) · University Hospitals Cleveland Medical Center (2) · Wake Forest University Health Sciences (2) · Biomedis International Ltd. (1) · Bispebjerg Hospital (1) · Changqing Yang (1) · Chiang Mai University (1) · Chongqing Medical University (1) · Clinical Hospital Merkur (1)
United States (23) · Denmark (7) · Brazil (6) · China (6) · United Kingdom (6) · Canada (5) · Czechia (3) · Italy (3) · Poland (3) · Belgium (2) · Chile (2) · Greece (2) · Israel (2) · Japan (2) · Spain (2)
Hans-Henrik Parving, MD,DMSc,Prof (2) · Antoine Trammell, MD, MPH (1) · Bertram Pitt, MD (1) · Bjorn Eriksson, MD (1) · Bobby V Khan, MD, PhD (1) · Bradley Maron, MD (1) · Christina L. Mitchell, M.D. (1) · Claus Bistrup, MD, ph.d. (1) · Denis Martinez, MD, PhD (1) · Dirk Elston, MD (1) · Eduard Shantsila, PhD (1) · Eduardo M. Krieger, Doctor (1)
PMID 33586138, PMID 33107592, PMID 11904577, PMID 12479763, PMID 12873814, PMID 15106785, PMID 16123474, PMID 16316360, PMID 17093067, PMID 18391085, PMID 19570764, PMID 20651602, PMID 21423678, PMID 21444835, PMID 21502568, PMID 21536989, PMID 21804623, PMID 22773022, PMID 22948302, PMID 24184249, PMID 24331202, PMID 24338935, PMID 24464960, PMID 24905296, PMID 25164945, PMID 25410653, PMID 25501057, PMID 25515841, PMID 25906818, PMID 26116627, PMID 26253568, PMID 26414968, PMID 27007793, PMID 27122492, PMID 27707827, PMID 29433578, PMID 29463627, PMID 29587582, PMID 29604289, PMID 29655877, PMID 29669139, PMID 29724188, PMID 30286821, PMID 31074184, PMID 31355878, PMID 32905623, PMID 32909497, PMID 33403831, PMID 34362264, PMID 36398903
2008 (1), K23HL093214 (1), K24HL103845 (1), R01HL109634 (1), U01AR079752 (1), UL1TR001102 (1)