19 completed, 9 unknown, 5 terminated, 4 recruiting. 40 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 40 | Completed 19, Unknown 9, Terminated 5, Recruiting 4, Withdrawn 2, Active not recruiting 1 |
Follow Sodium Bicarbonate: new trials by email Literature Review of Sodium Bicarbonate trials Research Report on Sodium Bicarbonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients Sodium bicarbonate, Tris-hydroxymethyl Aminomethane - Metabolic Acidosis | Phase 4 | Recruiting | Mayo Clinic | 250 | 2026-09-14 | 2026-09-21 |
| Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury Sodium Bicarbonate 8.4% Solution for Injection, Balanced crystalloid solution - Acute Kidney Injury, Metabolic Acidosis | Phase 4 | Recruiting | Universität Münster | 660 | 2026-05-07 | 2026-09-04 |
| Prophylactic Analgesia for Bladder Botox Injections Phenazopyridine, 1% lidocaine with sodium bicarbonate - Urinary Incontinence, Urinary Incontinence, Urge | Phase 4 | Withdrawn | Montefiore Medical Center | 2025-07-01 | 2025-07-18 | |
| Postoperative Analgesia in Laparoscopic Gynecological Surgeries Group M (lidocaine with Magnesium sulfate), Group B (lidocaine with Sodium bicarbonate), Group C (lidocaine with saline) - Postoperative Pain | Phase 4 | Unknown | Assiut University | 90 | 2024-10-01 | 2024-07-09 |
| Exploratory Study on the Treatment of Gout With Potassium Citrate Sustained-release Tablets Sodium Bicarbonate Oral Capsule, Potassium Citrate Tablets, uric-acid-lowering drug - Hyperuricemia or Gout, Nephrolithiasis | Phase 4 | Recruiting | Huashan Hospital | 312 | 2024-04-10 | 2025-05-13 |
| Combination of Buffered Anesthetic to Treat Mandibular Molars Sodium bicarbonate, Lidocaine w/ epi, Articaine w/ epi - Symptomatic Irreversible Pulpitis | Phase 4 | Terminated | Indiana University | 40 | 2023-12-05 | 2025-05-13 |
| Exploratory Pilot Study to Evaluate the Pharmacokinetic Profile of Magaldrate Sodium alginate + sodium bicarbonate + magaldrate + simeticone - Healthy | Phase 4 | Completed | Tecnoquimicas | 10 | 2023-10-31 | 2024-04-16 |
| Bicarbonate for In-Hospital Cardiac Arrest Sodium bicarbonate, Sodium chloride - Cardiac Arrest | Phase 4 | Active not recruiting | Lars Wiuff Andersen | 778 | 2023-02-06 | 2026-02-17 |
| Is Hyaluronic Acid Gel Effective on Oral Mucositis in Children Who Receiving Chemotherapy Hyaluronic acid, Sodium bicarbonate - Oral Mucositis | Phase 4 | Completed | Yuzuncu Yil University | 40 | 2022-04-01 | 2023-04-18 |
| OZOCLO_MUCOSITIS: a New Protocol for Prevention of Oral Mucositis 1. alpha acid lipoic - tables, 2. ozonated oil - mouthwash, 3. chlorhexidine 0,2% - mouthwash - Mucositis (MeSH Unique ID: D052016), Stomatitis (MeSH Unique ID: D013280) | Phase 4 | Unknown | University of Palermo | 80 | 2022-03-10 | 2022-01-27 |
| Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients Sodium bicarbonate, Placebo - Metabolic Acidosis, Kidney Transplant; Complications | Phase 4 | Recruiting | University of Colorado, Denver | 120 | 2021-12-01 | 2025-05-29 |
| Coronavirus Induced Acute Kidney Injury: Prevention Using Urine Alkalinization Sodium bicarbonate, Standard of Care - COVID, Coronavirus | Phase 4 | Terminated | West Virginia University | 3 | 2020-10-05 | 2023-12-22 |
| Bicarbonate vs Heparin Catheter Lock in Chronic Hemodialysis Patients Sodium Bicarbonate 7.5% Injection, Heparin Sodium, 1000 Units/mL Injectable Solution 1 - End Stage Renal Disease, Vascular Access Complication | Phase 4 | Unknown | Hospital General "Dr. Miguel Silva" de Morelia | 60 | 2019-09-11 | 2020-04-30 |
| Effectiveness of Urinary Alkalinizing Agents on Kidney Stone Risk Baking Soda, LithoLyte - Kidney Stone | Phase 4 | Completed | University of Wisconsin, Madison | 31 | 2019-08-28 | 2021-11-22 |
| Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes sodium bicarbonate - Type 1 Diabetes, Diabetic Nephropathy | Phase 4 | Completed | University of Colorado, Denver | 45 | 2017-01-01 | 2026-06-17 |
| Preventing contrAst Induced Nephropathy After TranscathEter Aortic Valve Replacement sodium bicarbonate, hypotone saline - Aortic Valve Disease, Chronic Kidney Disease | Phase 4 | Unknown | St. Antonius Hospital | 200 | 2016-10-01 | 2017-04-19 |
| Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia lidocaine, sodium bicarbonate - Local Anesthesia | Phase 4 | Terminated | University of Nebraska | 70 | 2016-01-08 | 2023-08-21 |
| Effects of Oral Sodium Bicarbonate Supplementation in Haemodialysis Patients (BicHD) sodium bicarbonate 500mg capsules - End-stage Renal Disease | Phase 4 | Completed | Imperial College Healthcare NHS Trust | 44 | 2015-11-01 | 2016-10-03 |
| Effects of Hypertonic Saline Solution (NACL 3%+NAHCO3) on Nasal Inflammation in Children With AR. RinASol- Pilot Study hypertonic saline solution (NACL 3%+NAHCO3), Saline Solution (NACL 0,9%) - Allergic Rhinitis | Phase 4 | Completed | Stefania La Grutta, MD | 30 | 2015-10-01 | 2017-01-12 |
| Oral Hygiene Regimen in Patients on HCT .02% Chlorohexidine Gluconate, 3% Sodium Bicarbonate, Nystatin 10000U/ml - Oral Mucositis | Phase 4 | Unknown | Riyadh Colleges of Dentistry and Pharmacy | 45 | 2015-09-01 | 2016-01-25 |
Showing 20 of 40. Sign in to see all of them.
Acute Kidney Injury (5) · Acidosis (3) · Kidney Failure, Chronic (3) · Renal Insufficiency, Chronic (3) · Stomatitis (3) · Heart Arrest (2) · Mucositis (2) · Pain (2) · Agnosia (1) · Aortic Valve Disease (1) · Arrhythmias, Cardiac (1) · COVID-19 (1) · Cardiovascular Diseases (1) · Coronary Artery Disease (1) · Coronary Disease (1)
Mayo Clinic (2) · University of Colorado, Denver (2) · Allina Health System (1) · Assiut University (1) · Azienda USL Reggio Emilia - IRCCS (1) · Baptist Health South Florida (1) · Bayer (1) · CardioVascular Research Foundation, Korea (1) · Clinical Hospital Centre Zagreb (1) · Duke University (1) · GlaxoSmithKline (1) · Hospital General "Dr. Miguel Silva" de Morelia (1) · Huashan Hospital (1) · Hull University Teaching Hospitals NHS Trust (1) · Imperial College Healthcare NHS Trust (1)
United States (14) · Italy (5) · United Kingdom (3) · South Korea (2) · Turkey (Türkiye) (2) · Brazil (1) · Canada (1) · China (1) · Denmark (1) · Germany (1) · Israel (1) · Japan (1) · Mexico (1) · Netherlands (1)
Abduraheem Mohamed, MBBS,BSc,MRCS (1) · Alexander Zarbock, MD (1) · Ankit Sakhuja, MD (1) · Antonio Manari, MD (1) · Brendan BJ Barrett, MD, MSc (1) · Damien Ashby, PhD, MRCP (1) · Daniel Carradice, MBBS,MRCS,DipHE (1) · David M Gurda, PharmD (1) · Essam Ezzat Abdel Hakeem, M.D. (1) · Ferruccio Conte, MD (1) · Gad Bar-Joseph (1) · Ian Chetter, MBChB,MD,FRCS (1) · Israel Campos, M.D. (1) · Jacob Sellon, MD (1)
PMID 10195475, PMID 14569436, PMID 15085035, PMID 15150204, PMID 15519007, PMID 16807414, PMID 16935736, PMID 16949378, PMID 17276670, PMID 17943084, PMID 18702961, PMID 19217695, PMID 21270583, PMID 2179802, PMID 22382793, PMID 22403968, PMID 24500238, PMID 27411777, PMID 27552990, PMID 27557865, PMID 28057030, PMID 28075506, PMID 31977509, PMID 32786044, PMID 39249590, PMID 42273960, PMID 8894861
2025 (1), R01DK130255 (1)