10 completed, 2 recruiting, 2 terminated, 1 withdrawn. 13 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 8, Recruiting 2, Terminated 2, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
Follow Smoking Abstinence: new trials by email Literature Review of Smoking Abstinence trials Research Report on Smoking Abstinence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating the Effect of Nicotine on Eye Movements and Related Behaviors in Electronic Cigarette Users, NICS-EYES Trial Avoidance, Biospecimen Collection, Cigarette Smoking - Cigarette Smoking-Related Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 25 | 2026-08-17 | 2026-10-05 |
| CSD231005 Nicotine Pouch Biomarkers of Exposure Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine - Tobacco Use, Smoking | Not applicable | Completed | RAI Services Company | 200 | 2024-08-22 | 2025-04-11 |
| Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture Healing Tobacco Heating System (THS), Smoking abstinence - Smoking, Tibia Fracture | Not applicable | Recruiting | University Hospital Tuebingen | 150 | 2023-06-02 | 2024-12-11 |
| Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease Cigarette, THS, Smoking Abstinence - Cardiovascular Diseases, Smoking | Not applicable | Withdrawn | Philip Morris Products S.A. | 2023-03-15 | 2024-11-18 | |
| Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms. THS use, Cigarette, Smoking Abstinence - COPD, Smoking | Not applicable | Terminated | Philip Morris Products S.A. | 715 | 2022-12-16 | 2024-09-26 |
| Effects of Smoking State on Decision Making smoking abstinence, smoking satiety - Behavior | Not applicable | Completed | Wake Forest University Health Sciences | 5 | 2022-09-01 | 2026-05-01 |
| Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence P4M3 CA35, P4M3 CM35, CIG - Nicotine, Vaping | Not applicable | Completed | Philip Morris Products S.A. | 74 | 2022-07-15 | 2024-03-13 |
| Reduction of Exposure, Inflammation, and Oxidative Stress Following at Least 2 Years of Switching to THS Use Compared to Cigarette Smoking THS use, Cigarette smoking, Smoking abstinence - Inflammation, Oxidative Stress | Completed | Philip Morris Products S.A. | 974 | 2022-06-13 | 2026-05-08 | |
| Nicotine Withdrawal and Reward Processing Smoking Abstinence, Ad Lib Smoking - Cigarette Smoking, Nicotine Dependence | Not applicable | Completed | University of Oklahoma | 58 | 2022-06-02 | 2024-05-08 |
| Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior Smoking Abstinence, Ad Lib Smoking - Cigarette Smoking, Nicotine Withdrawal | Not applicable | Terminated | Duke University | 21 | 2019-09-10 | 2021-05-20 |
| BRP1802 Smoking Abstinence Study Smoking Abstinence - Smoking, Smoking Cessation | Not applicable | Completed | RAI Services Company | 70 | 2019-05-30 | 2021-07-27 |
| Mechanisms of the Nicotine Metabolism Effect on Tobacco Dependence Smoking abstinence - Cigarette Smoking | Not applicable | Completed | University of California, San Francisco | 305 | 2012-07-01 | 2015-12-03 |
| Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls smoking abstinence - Tobacco Use Disorder, Schizophrenia | Phase 2 | Completed | Brown University | 60 | 2009-06-01 | 2012-04-27 |
| Neuroimaging Decision Making and Response Inhibition During Smoking Abstinence Smoking Abstinence - Smoking | Not applicable | Completed | Duke University | 62 | 2007-01-01 | 2014-07-23 |
| Neuroimaging Attentional Impairment During Abstinence Smoking Abstinence - Smoking | Not applicable | Completed | Duke University | 80 | 2005-06-01 | 2013-03-28 |
Smoking (9) · Tobacco Use (4) · Cigarette Smoking (3) · Smoking Cessation (2) · Tobacco Use Disorder (2) · Atherosclerosis (1) · Behavior (1) · Cardiovascular Diseases (1) · Coronary Artery Disease (1) · Inflammation (1) · Peripheral Arterial Disease (1) · Pulmonary Disease, Chronic Obstructive (1) · Recurrence (1) · Schizophrenia (1) · Tibial Fractures (1)
Philip Morris Products S.A. (4) · Duke University (3) · RAI Services Company (2) · Brown University (1) · Ohio State University Comprehensive Cancer Center (1) · University Hospital Tuebingen (1) · University of California, San Francisco (1) · University of Oklahoma (1) · Wake Forest University Health Sciences (1)
United States (11) · Germany (3) · Bulgaria (2) · Czechia (2) · Japan (2) · United Kingdom (2) · Greece (1) · Poland (1) · Romania (1) · Slovakia (1)
Christelle Haziza, PhD (3) · Francis J McClernon, Ph.D (2) · Bobbette Jones, DrPH (1) · Brian Keyser, PhD (1) · Jason A Oliver, PhD (1) · Jennifer Tidey, Ph.D. (1) · Merideth Addicott, PhD (1) · Neal L Benowitz, MD (1) · Patrick Tomko, PhD, CSCS (1) · Patrick Winiger, MD (1)
PMID 30242831, PMID 31812759, PMID 39882959
K23DA042898 (1), R21DA045970 (1)