12 completed, 5 terminated, 2 recruiting, 2 unknown. 24 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 24 | Completed 12, Terminated 5, Recruiting 2, Unknown 2, Withdrawn 2, Active not recruiting 1 |
| Phase 2 | 6 | Completed 4, Active not recruiting 1, Withdrawn 1 |
Follow Saline Solution, Hypertonic: new trials by email Literature Review of Saline Solution, Hypertonic trials Research Report on Saline Solution, Hypertonic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients. Hypertonic saline solution - TBI Traumatic Brain Injury | Phase 3 | Recruiting | Nantes University Hospital | 760 | 2026-04-21 | 2026-07-29 |
| Hypertonic Saline in Posterior Spinal Fusion Normosol-R, buffered 2% hypertonic saline - Scoliosis Idiopathic, Scoliosis;Congenital | Phase 2 / Phase 3 | Withdrawn | Joseph D. Tobias | 2025-12-01 | 2025-11-10 | |
| A Phase II/III of Hepenofovir Fumarate Tablets (HTS) for Chronic Hepatitis B HTS 20mg, HTS 30mg, HTS 40mg - Chronic Hepatitis B | Phase 2 / Phase 3 | Active not recruiting | Xi'an Xintong Pharmaceutical Research Co.,Ltd. | 1444 | 2025-07-01 | 2025-10-02 |
| Implications of Post-Operative Irrigation Fluid's Osmolarity on the Recurrence of Non-Muscle Invasive Bladder Cancer Following Transurethral Resection Continuous Bladder Irrigation with distilled water, Continuous Bladder Irrigation with normal saline, Continuous Bladder Irrigation with hypertonic saline - Bladder (Urothelial, Transitional Cell) Cancer, Nonmuscle Invasive Bladder Cancer | Phase 2 / Phase 3 | Completed | Ain Shams University | 150 | 2024-10-01 | 2025-12-29 |
| Benefits of Inhalation of Hypertonic Saline Solution Prior to Physiotherapy ELTGOL Technique in Bronchiectasis Hypertonic saline, Isotonic saline, ELTGOL - Bronchiectasis Adult | Phase 3 | Recruiting | Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta | 57 | 2024-06-01 | 2024-07-03 |
| Sodium Lactate Versus Hypertonic Saline Solution in the Treatment of Intracranial Hypertensive Episodes in Severe Brain Injured Patients Lactate, Sodium, Hypertonic saline - Intra Cerebral Hypertension, Lactate Sodium Solution | Phase 3 | Unknown | University Hospital, Geneva | 52 | 2024-01-01 | 2023-10-31 |
| Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis Hypertonic Saline Solution, 1 Ml, Adrenaline - Acute Bronchiolitis Due to Respiratory Syncytial Virus | Phase 3 | Unknown | Combined Military Hospital, Pakistan | 60 | 2023-11-01 | 2024-08-22 |
| Hypertonic Saline Therapy in Ambulatory Heart Failure Unit. Hypertonic saline solution plus intravenous furosemide, Intravenous furosemide - Heart Failure | Phase 3 | Completed | Puerta de Hierro University Hospital | 167 | 2021-01-01 | 2023-11-09 |
| Randomised Open Label Trial of Hypertonic Saline and Carbocisteine in Bronchiectasis (CLEAR) Hypertonic saline, Carbocysteine 750 MG - Bronchiectasis | Phase 3 | Completed | Belfast Health and Social Care Trust | 288 | 2018-06-27 | 2025-05-02 |
| Treating Brain Swelling in Pediatric Cerebral Malaria Mechanical ventilation, Hypertonic saline - Malaria, Cerebral | Phase 3 | Completed | Michigan State University | 57 | 2018-01-08 | 2025-03-17 |
| Comparison of the Effects of an Hypertonic Solution With Ringer Lactate on Right Ventricular Function Following Cardiac Surgery Ringer Lactate (10ml/kg) fluid expansion, Hypertonic saline (3ml/kg) fluid expansion - Right Ventricular Impaired Function, Hypovolemia | Phase 3 | Completed | University Hospital, Grenoble | 30 | 2016-08-01 | 2018-04-30 |
| Saline Hypertonic in Preschoolers + CT Active Treatment Group 7% Hypertonic Saline, Control Group 0.9% Isotonic Saline - Cystic Fibrosis | Phase 2 / Phase 3 | Completed | University of Washington, the Collaborative Health Studies Coordinating Center | 116 | 2015-03-24 | 2024-03-12 |
| Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis 3% Saline, 0.9% Normal Saline - Acute Viral Bronchiolitis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 778 | 2012-10-01 | 2014-07-28 |
| Hypertonic Saline and Terlipressin for Sepsis-associated Hypotension Hypertonic Saline and Terlipressin, Normal saline and norepinephrine - Septic Shock, Sepsis-associated Hypotension | Phase 3 | Terminated | Hospital General de Ciudad Real | 21 | 2012-06-01 | 2014-03-10 |
| Sargramostim or Hypertonic Saline Before Sentinel Lymph Node Biopsy in Treating Patients With Stage IB-II Melanoma sargramostim, sentinel lymph node biopsy, laboratory biomarker analysis - Stage IB Melanoma, Stage IIA Melanoma | Phase 3 | Withdrawn | Jonsson Comprehensive Cancer Center | 2011-08-05 | 2020-07-27 | |
| Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Mannitol, Hypertonic Saline - Traumatic Brain Injury, Elevated Intracranial Pressure | Phase 3 | Terminated | University of Cincinnati | 5 | 2010-04-01 | 2013-03-05 |
| Safety and Efficacy of Low Dose Hypertonic Saline Solution and High Dose Furosemide for Congestive Heart Failure furosemide and hypertonic saline solution, furosemide - Congestive Heart Failure, Renal Insufficiency | Phase 3 | Completed | Aspirus Heart and Vascular Institute-Research and Education | 50 | 2009-11-01 | 2012-02-09 |
| Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values Hypertonic saline, Mannitol - Traumatic Brain Injury | Phase 3 | Terminated | Direction Centrale du Service de Santé des Armées | 30 | 2008-07-01 | 2012-08-08 |
| The Effect of Hypertonic Saline on the Lung Clearance Index in Patients With Cystic Fibrosis hypertonic saline (7 %) and isotonic saline (0.9%) - Cystic Fibrosis | Phase 3 | Completed | The Hospital for Sick Children | 20 | 2008-03-01 | 2013-09-02 |
| Nebulized Hypertonic Saline for Bronchiolitis Nebulized 3% saline, Nebulized 0.9% saline - Bronchiolitis | Phase 2 / Phase 3 | Completed | Children's Hospital Los Angeles | 447 | 2008-02-01 | 2024-11-05 |
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Brain Injuries, Traumatic (4) · Bronchiolitis (3) · Cystic Fibrosis (3) · Heart Failure (2) · Respiratory Tract Diseases (2) · Brain Injuries (1) · Bronchial Diseases (1) · Bronchiectasis (1) · Bronchiolitis, Viral (1) · Cardio-Renal Syndrome (1) · Coma (1) · Digestive System Diseases (1) · Genetic Diseases, Inborn (1) · Hepatitis B, Chronic (1) · Hypovolemia (1)
University of Washington (2) · Ain Shams University (1) · Aspirus Heart and Vascular Institute-Research and Education (1) · Assistance Publique - Hôpitaux de Paris (1) · Belfast Health and Social Care Trust (1) · Children's Hospital Los Angeles (1) · Combined Military Hospital, Pakistan (1) · Direction Centrale du Service de Santé des Armées (1) · Hospital General de Ciudad Real (1) · Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (1) · Jonsson Comprehensive Cancer Center (1) · Joseph D. Tobias (1) · Michigan State University (1) · Nantes University Hospital (1) · Puerta de Hierro University Hospital (1)
United States (8) · Canada (5) · France (5) · Spain (4) · Australia (1) · Belgium (1) · China (1) · Denmark (1) · Egypt (1) · Italy (1) · Malawi (1) · Netherlands (1) · Pakistan (1) · United Arab Emirates (1) · United Kingdom (1)
Myron L Weisfeldt, MD (2) · Brian A Kuzik, MD, FRCP (1) · Felix Ratjen, MD (1) · Felix Ratjen, MD, PhD, FRCPC (1) · German Larrain, MD (1) · Harm Tiddens, MD, PhD (1) · J. Stuart Elborn (1) · Lori Shutter, MD (1) · Margaret Rosenfeld, MD, MPH (1) · Marta Cobo Marcos, MD (1) · Montserrat Vendrell, PhD MD (1) · Peter T P Bye, PhD (1)
PMID 25072443, PMID 37319354, PMID 12675760, PMID 16421364, PMID 19884591, PMID 19953579, PMID 20435858, PMID 20924011, PMID 21178763, PMID 24862623, PMID 25452661, PMID 27549684, PMID 28470580, PMID 28586918, PMID 29265171, PMID 34020114, PMID 35286860
U01HL077863 (2), R01CA120228 (1), U01AI126610 (1)