20 completed, 5 withdrawn, 4 unknown, 3 terminated. 33 Phase 2, 8 Phase 1, 6 Phase 3.
Follow Saline Solution, Hypertonic: new trials by email Literature Review of Saline Solution, Hypertonic trials Research Report on Saline Solution, Hypertonic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hypertonic Saline in Posterior Spinal Fusion Normosol-R, buffered 2% hypertonic saline - Scoliosis Idiopathic, Scoliosis;Congenital | Phase 2 / Phase 3 | Withdrawn | Joseph D. Tobias | 2025-12-01 | 2025-11-10 | |
| A Phase II/III of Hepenofovir Fumarate Tablets (HTS) for Chronic Hepatitis B HTS 20mg, HTS 30mg, HTS 40mg - Chronic Hepatitis B | Phase 2 / Phase 3 | Active not recruiting | Xi'an Xintong Pharmaceutical Research Co.,Ltd. | 1444 | 2025-07-01 | 2025-10-02 |
| Implications of Post-Operative Irrigation Fluid's Osmolarity on the Recurrence of Non-Muscle Invasive Bladder Cancer Following Transurethral Resection Continuous Bladder Irrigation with distilled water, Continuous Bladder Irrigation with normal saline, Continuous Bladder Irrigation with hypertonic saline - Bladder (Urothelial, Transitional Cell) Cancer, Nonmuscle Invasive Bladder Cancer | Phase 2 / Phase 3 | Completed | Ain Shams University | 150 | 2024-10-01 | 2025-12-29 |
| Effect of Fluid Resuscitation on Lactate in Traumatic Injury Patients 3% hypertonic Saline, Ringer's lactated solution, 0.9% Normal saline - Fluid Resuscitation | Phase 1 / Phase 2 | Unknown | Assiut University | 150 | 2024-08-01 | 2024-04-17 |
| The Aim of This Study is to Compare the Efficacy of Perioperative Hypertonic Saline 3% Versus Normal Saline (0.9%) in Decreasing Recurrence Risk in Non-muscle Invasive Bladder Cancer Hypertonic Saline - TCC | Phase 2 | Unknown | Kaplan Medical Center | 150 | 2021-01-20 | 2021-02-18 |
| Effects of Adding Hypertonic Saline Solutions and/or Etilefrine to Standard Diuretics Therapy in Hepatic Ascites Oral standard diuretics therapy, Hypertonic saline solution, Etilefrine - Hepatic Ascites | Phase 2 | Completed | Hala Abd EL-Tawab Ibrahim Radwan | 90 | 2017-11-30 | 2021-03-08 |
| Safety & Tolerability of Hypertonic Saline Administration Via Intraosseous Access Intraosseous, Hypertonic saline - Stroke, Intracranial Hypotension | Phase 2 | Completed | Ohio State University | 6 | 2017-04-21 | 2019-07-09 |
| Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia VX-371, Hypertonic Saline, Placebo (0.17% saline) - Primary Ciliary Dyskinesia | Phase 2 | Completed | Parion Sciences | 123 | 2016-08-01 | 2021-12-16 |
| Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa 23.4% Hypertonic saline - Hidradenitis Suppurativa | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 21 | 2016-08-01 | 2025-03-28 |
| A Study to Evaluate the Safety and Efficacy of VX-371 in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation VX-371 + HS, Hypertonic saline, Placebo - Cystic Fibrosis | Phase 2 | Completed | Parion Sciences | 147 | 2016-02-01 | 2021-07-29 |
| IVF in Pediatric Concussion Hypertonic Saline - Pediatric Mild Traumatic Brain Injury | Phase 1 / Phase 2 | Terminated | Washington University School of Medicine | 2 | 2015-10-01 | 2016-04-28 |
| Study of Stroke Related Edema Treatments Conivaptan, Hypertonic saline, Mannitol - Acute Cerebrovascular Accident, Cerebral Edema | Phase 2 | Withdrawn | University of Florida | 2015-09-01 | 2016-12-14 | |
| Clearing Lungs With Epithelial Sodium Channel (ENaC) Inhibition in Cystic Fibrosis (CF) P-1037, Hypertonic Saline, Saline - Cystic Fibrosis | Phase 2 | Completed | Parion Sciences | 142 | 2015-04-01 | 2021-07-26 |
| Saline Hypertonic in Preschoolers + CT Active Treatment Group 7% Hypertonic Saline, Control Group 0.9% Isotonic Saline - Cystic Fibrosis | Phase 2 / Phase 3 | Completed | University of Washington, the Collaborative Health Studies Coordinating Center | 116 | 2015-03-24 | 2024-03-12 |
| Metabolic Effects of Furosemide +HSS in Refractory Ascites intravenous furosemide, Hypertonic saline solutions, Seriated paracentesis - Ascites, Cirrhosis | Phase 2 | Completed | University of Palermo | 40 | 2013-12-01 | 2016-07-01 |
| Nebulized Hypertonic Saline for Mechanically Ventilated Children Hypertonic saline (3%), Placebo (0.9% saline) - Respiratory Failure | Phase 1 / Phase 2 | Completed | University Hospitals Cleveland Medical Center | 18 | 2013-10-01 | 2016-06-28 |
| Treating Wheezing in Children With Hypertonic Saline (TWICS) hypertonic saline, saline - Wheeze | Phase 2 | Withdrawn | Dr. Michael Flavin | 2013-10-01 | 2015-11-13 | |
| Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF) Subjects Xylitol, Hypertonic saline - Cystic Fibrosis | Phase 1 / Phase 2 | Completed | Joseph Zabner | 63 | 2013-01-22 | 2021-06-25 |
| Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium) - Traumatic Brain Injury, Subdural Hematoma | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2012-07-01 | 2016-12-12 | |
| Preventive Inhalation of Hypertonic Saline in Infants With Cystic Fibrosis 6% Hypertonic Saline (HS), 4mL, 0.9% Isotonic Saline (IS), 4mL - Cystic Fibrosis Lung Disease | Phase 2 | Completed | Heidelberg University | 42 | 2012-06-01 | 2017-10-26 |
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Cystic Fibrosis (8) · Bronchiolitis (5) · Brain Edema (3) · Ascites (2) · Heart Failure (2) · Renal Insufficiency (2) · Stroke (2) · Asthma (1) · Blast Crisis (1) · Brain Contusion (1) · Brain Diseases (1) · Brain Injuries (1) · Brain Injuries, Traumatic (1) · Bronchiectasis (1) · Bronchiolitis, Viral (1)
Parion Sciences (3) · Joseph Zabner (2) · Ain Shams University (1) · Assiut University (1) · Barnes-Jewish Hospital (1) · Belfast Health and Social Care Trust (1) · Beth Israel Deaconess Medical Center (1) · Children's Hospital Los Angeles (1) · Dr. Michael Flavin (1) · Hala Abd EL-Tawab Ibrahim Radwan (1) · Heidelberg University (1) · Johns Hopkins University (1) · Joseph D. Tobias (1) · Kaplan Medical Center (1) · M.D. Anderson Cancer Center (1)
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Karl Donn (2) · Alison Church, MD (1) · Angela K Lumba, MD (1) · Anitha Vijayan, M.D. (1) · Antonio Pinto, MD (1) · Beth L Laube, PhD (1) · Brian A Kuzik, MD, FRCP (1) · Brian Kuzik, MD (1) · Brian P Walcott, MD (1) · Brian V Nahed, MD (1) · Edimar A Bocchi, Professor (1) · Felix Ratjen, MD (1) · Felix Ratjen, MD, PhD, FRCPC (1) · Gamal A Badra, professor (1) · Gregory A Ewald, M.D. (1)
PMID 11232182, PMID 12660656, PMID 15196097, PMID 16474108, PMID 17172977, PMID 17992382, PMID 19602136, PMID 20346637, PMID 20630539, PMID 21073773, PMID 21749847, PMID 21896198, PMID 22243938, PMID 22844565, PMID 24462960, PMID 24811138, PMID 24829672, PMID 24862623, PMID 26630543, PMID 27941973, PMID 27991854, PMID 28285098, PMID 28661458, PMID 28932357, PMID 29608812, PMID 30409023, PMID 30992841, PMID 31327670, PMID 32671834, PMID 34674574, PMID 3522371, PMID 35286860, PMID 37319354, PMID 37660715, PMID 680588
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