73 completed, 15 unknown, 8 terminated, 7 recruiting. 115 Phase 3, 18 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 115 | Completed 73, Unknown 15, Terminated 8, Recruiting 7, Withdrawn 7, Active not recruiting 2, Not yet recruiting 2, Suspended 1 |
| Phase 2 | 18 | Completed 7, Unknown 5, Withdrawn 5, Recruiting 1 |
Follow Propofol: new trials by email Literature Review of Propofol trials Research Report on Propofol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sevoflurane vs. Propofol for General Anesthesia in Patients With Acute Ischemic Stroke Treated With Endovascular Therapy Sevoflurane, propofol (drug) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 314 | 2026-06-22 | 2026-10-29 |
| Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation Ketofol, propofol (drug) - The Critically Ill Patient is Requiring Intubation, Septic Shock | Phase 3 | Active not recruiting | Helwan University | 70 | 2026-05-13 | 2026-10-15 |
| HSK3486 (Cipepofol) Injectable Emulsion for Induction of General Anesthesia in Pediatric Subjects Undergoing Elective Surgery HSK3486, propofol - General Anesthetic | Phase 3 | Not yet recruiting | Haisco Pharmaceutical Group Co., Ltd. | 400 | 2026-05-01 | 2026-04-06 |
| Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration Remimazolam, Propofol - Anesthesia, Sedation | Phase 3 | Completed | Massachusetts General Hospital | 100 | 2026-03-03 | 2026-09-14 |
| The Effects of Remimazolam on Cerebral Blood Flow Following General Anesthesia Induction Remimazolam, Propofol (Group P) - Cerebral Blood Flow | Phase 3 | Completed | Jun Zhang | 52 | 2025-12-29 | 2026-04-15 |
| Inhaled Isoflurane for Sedation of Invasively Ventilated Patients With Cardiogenic Shock on Extracorporeal Membrane Oxygenation Inahled Isoflurane, Propofol, midazolam - Cardiogenic Shock, ECMO | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2025-09-15 | 2025-08-01 |
| A Trial of Remimazolam for Intraoperative Sedation in Pediatric and Adolescent Patients Remimazolam Tosilate for injection, Propofol Injection - Operative Sedation of Pediatric, Operative Sedation of Adolescent Patients | Phase 2 / Phase 3 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 249 | 2025-07-10 | 2026-06-04 |
| Best Hypnotic Drug Choice for Rapid Sequence Induction in the Operating Room direct IV injection, combination of Ketamine and Propofol - Rapid Sequence Induction | Phase 3 | Recruiting | Nantes University Hospital | 1218 | 2025-04-14 | 2025-12-02 |
| Effect of Remimazolam Sedation on Outcomes of Mechanically Ventilated Patients in the ICU Remimazolam, propofol - Remimazolam Besylate, Mechanically Ventilated ICU Patients | Phase 3 | Recruiting | Southeast University, China | 80 | 2025-04-01 | 2026-05-19 |
| Comparison of General Anesthesia Hemodynamics Between R and P in Patients Undergoing Laparoscopic Hepatectomy propofol, Remimazolam - Hypotension During Surgery | Phase 3 | Completed | Sun Yat-sen University | 88 | 2024-06-20 | 2024-12-03 |
| A Multicenter, Open, Controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of Cipepofol Injection for General Anesthesia in Pediatric Patients Undergoing Elective Surgery Cipepofol, Propofol - Anesthesia | Phase 3 | Completed | Haisco Pharmaceutical Group Co., Ltd. | 190 | 2024-04-07 | 2025-07-22 |
| Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery HSK3486, Propofol - General Anesthesia | Phase 3 | Completed | Haisco-USA Pharmaceuticals, Inc. | 465 | 2024-01-12 | 2025-10-10 |
| Propofol for Prophylaxis of Morphine Induced Pruritis in Caesarean Section Propofol - Pruritus Caused by Drug | Phase 3 | Unknown | Assiut University | 200 | 2024-01-01 | 2024-01-03 |
| Magnesium Sulfate as an Adjuvant to Propofol During Consious Sedation in Colonoscopy Magnesium Sulfate, Propofol - Magnesium, Intraoperative Analgesia | Phase 2 / Phase 3 | Unknown | Assiut University | 60 | 2024-01-01 | 2023-12-18 |
| Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome Propofol, Isoflurane - Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication | Phase 2 / Phase 3 | Recruiting | Guy's and St Thomas' NHS Foundation Trust | 20 | 2023-11-01 | 2026-06-04 |
| COnventional Vs. Optimised PERiprocedural Analgosedation Vs. Total IntraVEnous Anaesthesia for Pulsed-Field Ablation (COOPERATIVE-PFA) Remimazolam, Propofol - Atrial Fibrillation | Phase 3 | Completed | Charles University, Czech Republic | 127 | 2023-10-25 | 2025-02-03 |
| Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients Esketamine, Saline, Remifentanil + propofol - Septic Shock, Mechanical Ventilation Complication | Phase 3 | Unknown | Nanfang Hospital, Southern Medical University | 124 | 2023-05-31 | 2023-11-22 |
| Long-term Sedation With Remimazolam Besylate in Critically Ill Patients Remimazolam besylate, Propofol - Light Sedation, Mechanical Ventilation | Phase 3 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 728 | 2023-05-16 | 2023-05-26 |
| Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage Ketamine Hydrochloride, Propofol - Subarachnoid Hemorrhage, Aneurysmal | Phase 2 / Phase 3 | Withdrawn | Jenna L Leclerc MD, PhD | 2023-04-27 | 2023-05-01 | |
| Step 2 of A Two-step Trial to Evaluate the Effectiveness and Safety of Remimazolam Besylate for Sedation in ICU Patients Remimazolam besylate, Propofol, Remifentanil - Sedative, Mechanical Ventilation | Phase 3 | Completed | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 164 | 2023-02-28 | 2024-01-31 |
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Agnosia (7) · Respiratory Distress Syndrome (4) · Ischemic Stroke (3) · Pain (3) · Brain Injuries, Traumatic (2) · Breast Neoplasms (2) · Depressive Disorder, Treatment-Resistant (2) · Hypotension (2) · Neoplasms (2) · Pain, Postoperative (2) · Shock, Septic (2) · Subarachnoid Hemorrhage (2) · Acute Kidney Injury (1) · Acute Lung Injury (1) · Anxiety Disorders (1)
Haisco Pharmaceutical Group Co., Ltd. (5) · Jiangsu HengRui Medicine Co., Ltd. (5) · Assiut University (3) · B. Braun Melsungen AG (3) · Haisco-USA Pharmaceuticals, Inc. (3) · Merck Sharp & Dohme LLC (3) · Rennes University Hospital (3) · Sichuan Haisco Pharmaceutical Group Co., Ltd (3) · The Cleveland Clinic (3) · Cairo University (2) · M.D. Anderson Cancer Center (2) · Paion UK Ltd. (2) · Sedana Medical (2) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (2) · University Hospital, Bordeaux (2)
United States (25) · China (22) · France (12) · Germany (7) · Egypt (6) · Canada (4) · Switzerland (4) · United Kingdom (4) · Belgium (3) · Italy (3) · Russia (3) · Greece (2) · Netherlands (2) · Spain (2) · Taiwan (2)
Bruno Laviolle, MD (2) · Sameh Abdelkhalek Ahmed, MD (2) · Sherief Abd-Elsalam, MD (2) · Achim J Schmitz, MD (1) · Alexandre Conia (1) · Alexandre Lautrette (1) · Alibek Kh Mustafin, Professor (1) · Andrea O. Rossetti, MD (1) · Anis Aribogan, Prof., MD (1) · Antoine Roquilly (1) · Antonio Paulo Nassar Junior, MD (1) · Antonio Pesenti, MD (1) · Arnaud W. Thille (1) · Arthur Durand (1)
PMID 10981581, PMID 11465585, PMID 15949912, PMID 16278131, PMID 16672092, PMID 17059854, PMID 17485450, PMID 17591128, PMID 18806028, PMID 19348675, PMID 19512873, PMID 19607937, PMID 20370749, PMID 20878265, PMID 21950720, PMID 21963186, PMID 21983627, PMID 22012178, PMID 22250028, PMID 22436955, PMID 22580593, PMID 23015618, PMID 23359581, PMID 23427212, PMID 23439457, PMID 24465046, PMID 24900938, PMID 25009196, PMID 25009197, PMID 25164872, PMID 25480319, PMID 25887576, PMID 26210907, PMID 26588217, PMID 26615516, PMID 26709032, PMID 26721648, PMID 26907795, PMID 26922562, PMID 27866303, PMID 27942865, PMID 28483817, PMID 29532502, PMID 29916859, PMID 30068669, PMID 30229370, PMID 30232735, PMID 31154292, PMID 31315670, PMID 31645288
2016 (1), 2018 (1), 2023 (1)