221 completed, 62 unknown, 34 recruiting, 22 not yet recruiting. 263 Not applicable, 62 Phase 2, 26 Phase 3, 19 Phase 1, 18 Phase 4.
Follow this drug Literature Review of Probiotic trials Research Report on Probiotic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Real-world Study of Gastrointestinal Health and Mental Wellness in U.S. Adults Following 12 Weeks of Probiotic Supplementation. Probiotic - Healthy Adults Reporting Recurrent Gastrointestinal Symptoms | Not applicable | Not yet recruiting | Novonesis | 300 | 2027-01-01 | 2026-09-30 |
| Genitourinary Study of Fostering Lactobacillus to Optimize the Microbiome in Women's Health (GUD-FLORA) Lactobacillus crispatus probiotic - Recurrent UTIs | Phase 1 | Withdrawn | Duke University | 2026-12-01 | 2026-08-28 | |
| R-2487 in Patients With Sjogren's Syndrome (SS) R-2487 - Sjogren's Syndrome, Sjögren | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 36 | 2026-11-01 | 2026-09-28 |
| The Gut - PRO Study Probiotic, Placebo - Alzheimer Disease | Phase 1 | Recruiting | University of Wisconsin, Madison | 40 | 2026-10-01 | 2026-09-29 |
| Probiotics for Sustained Health Probiotic, Placebo - Upper Respiratory Tract Infection (URTI) | Not applicable | Not yet recruiting | BioGaia AB | 70 | 2026-09-25 | 2026-09-24 |
| CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial EXE-346 Probiotic, Placebo, Usual Care High Resolution Anoscopy (HRA) - HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma | Phase 2 | Recruiting | University of California, San Francisco | 90 | 2026-09-04 | 2026-09-15 |
| Probiotic Research for Mental Health in Adult Volunteers Probiotic, Placebo - Healthy Adult Participants | Not applicable | Not yet recruiting | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | 60 | 2026-09-01 | 2026-08-07 |
| Stress-buffering and Sleep Disturbance-resilient Effects of a Dual Bifidobacterium Longum Combination Under Short-term Travel Placebo, Probiotic - Healthy | Phase 2 | Not yet recruiting | Min-Tze LIONG | 60 | 2026-07-01 | 2026-07-09 |
| Study on the Effects and Mechanisms of Probiotic Supplementation in Ameliorating Uric Acid Metabolism in Asymptomatic Hyperuricemic Individuals Probiotic, Placebo - Asymptomatic Hyperuricemia | Not applicable | Not yet recruiting | Sun Yat-sen University | 68 | 2026-07-01 | 2026-06-16 |
| Efficacy and Safety of Probiotics for Anxiety Depression Probiotic, Placebo, Escitalopram - Anxiety Depression | Not applicable | Recruiting | Moon (Guangzhou) Biotechnology Co., Ltd. | 60 | 2026-06-15 | 2026-06-29 |
| Probiotic Improve Constipation Probiotic, Placebo, High-activity probiotic probiotic - Constipation | Not applicable | Recruiting | Wecare Probiotics Co., Ltd. | 105 | 2026-06-10 | 2026-06-09 |
| Probiotics for Constipation Relief in Adults Probiotic, Maltodextrin, High-activity probiotic group - Functional Constipation | Not applicable | Not yet recruiting | Wecare Probiotics Co., Ltd. | 105 | 2026-06-10 | 2026-06-09 |
| Effect of a Probiotic or Postbiotic on Gut Microbiome During Antibiotic Treatment Probiotic, Postbiotic, Placebo - Microbiome | Not applicable | Not yet recruiting | The Archer-Daniels-Midland Company | 126 | 2026-06-01 | 2026-05-19 |
| The Bloom Infant Probiotic (BIP) Study Probiotic, Matching placebo - Infant, Newborn, Immunity | Phase 2 | Recruiting | South Australian Health and Medical Research Institute | 360 | 2026-05-25 | 2026-05-28 |
| Administration of Oral Probiotic Streptococcus Salivarius K12 Probiotic - Oral Health | Not applicable | Active not recruiting | University of Zurich | 12 | 2026-05-06 | 2026-08-11 |
| Assessing the Efficacy of Probiotics in Prevention of NEC in Preterm Babies Probiotic, 10% dextrose - NEC, NEC - Necrotizing Enterocolitis | Not applicable | Active not recruiting | Hayatabad Medical Complex | 196 | 2026-04-01 | 2026-08-18 |
| An Intervention Study in Healthy Infants Aged 0-6 Months With Probiotics Lacticaseibacillus Rhamnosus LRa05 (LRa05) and Bifidobacterium Animalis Subsp. Lactis BLa80 (BLa80) vs. Placebo, for Promoting Gut Microbiome Development. Placebo (maltodextrin), Probiotic - Less Than 3 Months Old, Healthy Infants | Not applicable | Not yet recruiting | University College Cork | 300 | 2026-04-01 | 2026-04-01 |
| Probiotics Combined With Targeted Therapy Plus Immunotherapy in Bladder-Preserving Setting for Patients With MIBC Probiotic, Disitamab Vedotin, Toripalimab - Muscle Invasive Bladder Cancer (MIBC) | Phase 2 | Not yet recruiting | chenxu | 146 | 2026-03-26 | 2026-03-17 |
| Probiotic for Weight Management in Overweight and Obese Adults Probiotic, Placebo - Obesity | Not applicable | Not yet recruiting | Wecare Probiotics Co., Ltd. | 76 | 2026-03-20 | 2026-04-02 |
| Effects of a Probiotic Intervention on the Gut and Vaginal Microbiome in Patients With Advanced or Recurrent Ovarian Cancer Undergoing Treatment With Platinum Chemotherapy Biospecimen Collection, Placebo Administration, Probiotic - Advanced Ovarian Carcinoma, Recurrent Ovarian Carcinoma | Early Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 161 | 2026-03-06 | 2026-08-17 |
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Obesity (35) · Diarrhea (13) · Irritable Bowel Syndrome (12) · Overweight (12) · Respiratory Tract Infections (12) · Constipation (11) · Inflammation (9) · Gastrointestinal Diseases (7) · Periodontitis (7) · Premature Birth (7) · Anxiety Disorders (6) · Attention Deficit Disorder with Hyperactivity (6) · Depression (6) · Diabetes Mellitus, Type 2 (6) · Infections (6)
Wecare Probiotics Co., Ltd. (39) · Min-Tze LIONG (13) · Lallemand Health Solutions (9) · The Archer-Daniels-Midland Company (9) · AB Biotics, SA (8) · Danisco (6) · BioGaia AB (4) · Biopolis S.L. (4) · Société des Produits Nestlé (SPN) (4) · Universiti Sains Malaysia (4) · University of Copenhagen (4) · University of Florida (4) · University of Reading (4) · University of Wisconsin, Madison (4) · Centre hospitalier de l'Université de Montréal (CHUM) (3)
United States (60) · China (58) · Spain (37) · Malaysia (18) · Canada (16) · Brazil (15) · Italy (12) · United Kingdom (11) · Sweden (10) · Germany (9) · Denmark (8) · India (8) · Ireland (8) · Poland (8) · France (7)
Bobbi Langkamp-Henken, PhD (3) · Erik Rein-Hedin, MD (3) · Ai Zhou, Ph.D. (2) · Aleksandra M Cichonska, PhD (2) · Andreas Munk Petersen, MD, PhD, DMSc (2) · Bobbi Langkamp-Henken, Ph.D. (2) · Carles Lerin, PhD (2) · Duane Wombolt, MD (2) · Francesco Sofi, Prof. (2) · Gabriela Arias (2) · Idoia Ibero-Baraibar, PhD (2) · Jeffrey Pernica, MD (2) · Jinping Zhang, MD (2)
PMID 37870148, PMID 26427036, PMID 26706022, PMID 27288567, PMID 28239408, PMID 28923425, PMID 29731182, PMID 36149331, PMID 11921380, PMID 14657823, PMID 14679449, PMID 15942443, PMID 16157765, PMID 16172836, PMID 16187156, PMID 16878680, PMID 17318230, PMID 18181712, PMID 18281199, PMID 18539795, PMID 19179052, PMID 19240062, PMID 19285652, PMID 19302580, PMID 19525871, PMID 19682173, PMID 20084389, PMID 20144246, PMID 20485304, PMID 20545688, PMID 20645850, PMID 20811016, PMID 20834180, PMID 20980489, PMID 21157050, PMID 21448219, PMID 21520200, PMID 21821542, PMID 21873895, PMID 21945174, PMID 22013734, PMID 22019281, PMID 22097291, PMID 22254114, PMID 22694350, PMID 22768838, PMID 22836031, PMID 22895087, PMID 22899904, PMID 22916296
2019 (2), R01HD095158 (1), R01HL080074 (1), R01NR005337 (1), R03AG040669 (1), R61AG088913 (1), U24CA275417 (1)