10 completed, 5 unknown, 2 terminated, 1 active not recruiting. 8 Phase 2, 6 Phase 3, 6 Phase 4, 3 Not applicable, 1 Phase 1.
Follow Morphine sulphate: new trials by email Literature Review of Morphine sulphate trials Research Report on Morphine sulphate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Morphine or Ketamine for Analgesia Ketamine hydrochloride, Morphine sulphate - Abdominal Pain, Isolated Extremity Fracture | Phase 3 | Recruiting | Columbia University | 1010 | 2026-10-17 | 2026-10-20 |
| A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin - Cough, Refractory Chronic Cough | Phase 4 | Not yet recruiting | McMaster University | 124 | 2026-09-30 | 2026-10-19 |
| Dexmedetomidine Plus Low Dose Morphine Versus Standard Dose of Morphine in PCA in Children . standard dose morphine, low dose morphine plus dexmedetomidine - PCA, Children | Not applicable | Unknown | Beni-Suef University | 60 | 2023-02-01 | 2024-09-25 |
| Vital Signs-Integrated Patient-Assisted Intravenous Opioid Analgesia for Post Surgical Pain VPIA pump, Morphine - Pain, Respiratory Depression | Phase 2 / Phase 3 | Active not recruiting | KK Women's and Children's Hospital | 40 | 2021-03-31 | 2026-08-07 |
| Effect of Tramadol Versus Morphine on PD1 and PD1-ligand in Patients With Chronic Cancer Pain Tramadol Hydrochloride - Chronic Pain | Phase 2 / Phase 3 | Unknown | Assiut University | 15 | 2020-04-16 | 2021-01-14 |
| Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion PO Morphine, IV Fentanyl, IV Ketamine - Abortion in First Trimester | Phase 3 | Suspended | Dr. Marie Eve Sophie Bussiere-Cote | 123 | 2019-06-10 | 2022-09-08 |
| Effect of Intrathecal Morphine in Children Undergoing Major Abdominal Surgeries, Intrathecal Morphine - Major Abdominal Surgeries | Not applicable | Unknown | Assiut University | 45 | 2017-01-01 | 2017-05-23 |
| Morphine in Moderate Obstructive Sleep Apnoea Morphine sulphate - Obstructive Sleep Apnoea | Phase 3 | Terminated | Papworth Hospital NHS Foundation Trust | 6 | 2016-05-20 | 2018-11-29 |
| Morphine and/or Nalbuphine as Adjuvants in Ultrasound Guided Interscalene Block: for Shoulder Surgeries Morphine, Nalbuphine, Bupivacaine 0.5% - Rotator Cuff Tear | Phase 2 | Unknown | Assiut University | 80 | 2016-01-01 | 2017-05-22 |
| An Interventional Study for Patient With Cancer Pain to Evaluate the Efficacy and Safety of OxyNorm® Compared to Morphine Sulfate Through the IV Continuous Infusion. Oxycodone Hydrochloride, Morphine Sulphate - Cancer Pain | Phase 4 | Completed | Mundipharma Korea Ltd | 66 | 2015-11-01 | 2018-11-19 |
| Effect of Locally Administered Morphine and Bupivicaine on Acute and Chronic Postmastectomy Pain local instillation of morphine to surgical wound - Acute Pain, Chronic Pain | Phase 2 | Completed | Assiut University | 120 | 2015-01-01 | 2015-12-30 |
| A Study of TRV130 for the Treatment of Pain After Abdominoplasty TRV130, Morphine, Placebo - Pain | Phase 2 | Completed | Trevena Inc. | 200 | 2014-12-01 | 2020-09-16 |
| A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Morphine, Morphine plus dexmedetomidine - Chronic Pain | Phase 4 | Completed | Cukurova University | 40 | 2014-11-01 | 2018-06-19 |
| Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management Diclofenac, Morphine, Paracetamol - Renal Colic, Urinary Calculi | Phase 4 | Completed | Hamad Medical Corporation | 1645 | 2014-08-01 | 2015-03-18 |
| A Study of TRV130 for the Treatment of Pain After Bunionectomy TRV130, Morphine, Placebo - Acute Pain | Phase 2 | Completed | Trevena Inc. | 333 | 2014-04-01 | 2020-09-16 |
| Combined Intrathecal Morphine and Dexmedetomidine Analgesia Dexmedetomidine (Precedex), Bupivacaine, Morphine - Postoperative Pain | Phase 2 / Phase 3 | Completed | Assiut University | 90 | 2013-05-01 | 2015-05-06 |
| Intranasal Fentanyl Versus Intravenous Morphine in the Treatment of Severe Painful Sickle Cell Crises in Children Fentanyl Citrate, Morphine sulphate - Pain, Sickle Cell Disease | Phase 4 | Completed | University College Dublin | 31 | 2012-12-12 | 2018-09-24 |
| Effects of a Single Dose of Egalet® Morphine Combined With a Single Dose of Alcohol in Healthy Moderate Drinkers Morphine sulphate - Pain | Phase 1 | Completed | Egalet Ltd | 24 | 2008-12-01 | 2016-09-14 |
| Efficacy of Multimodal Opioid Therapy During Hepatic Resection Surgery Morphine sulphate, Morphine hydrochloride, remifentanil hydrochloride - Liver Dysfunction, Pain | Not applicable | Unknown | St Vincent's University Hospital, Ireland | 45 | 2007-09-01 | 2008-12-31 |
| A Efficacy and Safety Trial of Controlled Release (CR) Morphine in Cancer Patients Morphine Sulphate - Pain, Cancer | Phase 2 | Completed | Egalet Ltd | 36 | 2007-08-01 | 2016-08-29 |
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Pain (8) · Agnosia (5) · Chronic Pain (3) · Pain, Postoperative (3) · Acute Pain (2) · Abdominal Pain (1) · Anemia, Sickle Cell (1) · Anxiety Disorders (1) · Cancer Pain (1) · Cheyne-Stokes Respiration (1) · Chronic Cough (1) · Cough (1) · Depression (1) · Emergencies (1) · Fractures, Bone (1)
Assiut University (5) · Egalet Ltd (2) · Trevena Inc. (2) · Beni-Suef University (1) · Columbia University (1) · Cukurova University (1) · Dr. Marie Eve Sophie Bussiere-Cote (1) · Hamad Medical Corporation (1) · KK Women's and Children's Hospital (1) · McMaster University (1) · Mundipharma Korea Ltd (1) · Papworth Hospital NHS Foundation Trust (1) · Rambam Health Care Campus (1) · St Vincent's University Hospital, Ireland (1) · University College Dublin (1)
Egypt (5) · United States (3) · Canada (2) · Ireland (2) · Israel (1) · Lithuania (1) · Poland (1) · Qatar (1) · Singapore (1) · South Korea (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Amy L Drendel, DO, MS (1) · Ashley Waddington, MD, MPA (1) · Ayman A Mamdouh, Ass Prof (1) · Ban Leong Sng, MBBS, MMED (1) · Christine Andersen, M.Sc. (1) · Christine Andersen, MSc Pharm (1) · Daniel S Tsze, MD, MPH (1) · Dr.Sameer A. Pathan, MBBS, MCEM (1) · Franck Skobieranda, MD (1) · Ian Smith, MBBS (1) · Imran Satia, MD PhD (1) · Jinhyong Kang, Dr. Ph.D (1) · Kawser H Mohammed, Prof (1) · Mahmoud A Aly, Prof (1)
PMID 18987053, PMID 26993881, PMID 27002003, PMID 27755490, PMID 29670416
U01HD116253 (1)