20 completed, 10 recruiting, 5 terminated, 2 active not recruiting. 41 Phase 2, 7 Phase 3, 6 Phase 1.
Follow Ketamine Hydrochloride: new trials by email Literature Review of Ketamine Hydrochloride trials Research Report on Ketamine Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) - Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder | Phase 2 | Recruiting | Joshua Rosenblat | 120 | 2026-07-16 | 2026-07-29 |
| Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients Ketamine (0.5 mg/kg), Normal Saline (0.9% NaCl) - Critical Illness, Depressive Symptoms | Phase 2 | Recruiting | Hospital Italiano de Buenos Aires | 50 | 2026-05-14 | 2026-09-02 |
| Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression Ketamine hydrochloride, Minimally Enhanced Usual Care, Brief narrative intervention - Chronic Low Back Pain, Depression | Phase 2 | Recruiting | VA Office of Research and Development | 44 | 2025-12-03 | 2025-12-18 |
| A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients Ketamine Hydrochloride, Placebo - Depression | Phase 2 | Terminated | Mayo Clinic | 1 | 2025-07-07 | 2026-08-12 |
| Understanding and Treating Suicidal Ideation With Ketamine ketamine hydrochloride - Suicidal Ideation, Major Depressive Disorder (MDD) | Phase 2 / Phase 3 | Recruiting | The Royal's Institute of Mental Health Research | 36 | 2025-04-08 | 2026-05-19 |
| Ketamine-Assisted Recovery for Methamphetamine Use Disorder & HIV Ketamine, Psychotherapy - Methamphetamine Use Disorder | Phase 2 | Completed | Nicky Mehtani, MD, MPH | 17 | 2025-03-04 | 2026-08-12 |
| Ketamine for Combined Depression and Alcohol Use Disorder Ketamine Hydrochloride, Midazolam Hydrochloride - Depression, Alcohol Use Disorder | Phase 1 / Phase 2 | Recruiting | University Hospital of North Norway | 34 | 2025-01-20 | 2026-06-23 |
| Ketamine for Methamphetamine Use Disorder Ketamine Hydrochloride, Midazolam Hydrochloride - Substance Use Disorders, Substance Use | Phase 2 | Completed | University of Texas Southwestern Medical Center | 120 | 2024-09-11 | 2026-10-27 |
| Imaging Depression in Parkinson's Disease 11C-UCB-J, ketamine hydrochloride - Parkinson's Disease, Major Depressive Disorder | Phase 2 | Recruiting | Yale University | 120 | 2024-09-01 | 2026-03-10 |
| Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2) Ketamine, Naltrexone Pill, Placebo pill - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Stanford University | 150 | 2024-02-24 | 2026-04-24 |
| i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial Ketamine hydrochloride, i-CBT (Internet-based Cognitive Behavioural Therapy), Midazolam Hydrochloride - Major Depressive Disorder, Suicide | Phase 2 | Active not recruiting | University Health Network, Toronto | 76 | 2024-01-02 | 2026-10-06 |
| Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD Ketamine Hydrochloride - PTSD | Phase 1 / Phase 2 | Withdrawn | University of New Mexico | 2023-12-31 | 2024-03-12 | |
| Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage Ketamine Hydrochloride, Propofol - Subarachnoid Hemorrhage, Aneurysmal | Phase 2 / Phase 3 | Withdrawn | Jenna L Leclerc MD, PhD | 2023-04-27 | 2023-05-01 | |
| Ketamine & Crisis Response Plan for Suicidal Ideation in the ED Ketamine Hydrochloride, Crisis Response Plan - Suicide | Phase 2 / Phase 3 | Recruiting | The University of Texas Health Science Center at San Antonio | 24 | 2023-01-06 | 2026-09-30 |
| The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy Ketamine Hydrochloride - Drug Resistant Epilepsy, Medically Refractory Epilepsy | Phase 2 | Completed | Madeline Fields | 12 | 2022-08-26 | 2026-09-11 |
| Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression Ketamine Hydrochloride - Bipolar Disorder, Bipolar Depression | Phase 2 | Completed | Joshua Rosenblat | 41 | 2022-08-11 | 2026-03-05 |
| Ketamine for Treatment-Resistant Bipolar Disorder Ketamine Hydrochloride, Midazolam Hydrochloride - Bipolar Disorder, Bipolar Depression | Phase 2 | Completed | Joshua Rosenblat | 71 | 2022-07-04 | 2026-03-05 |
| Intramuscular Ketamine Effect on Postnasal Surgery Agitation Ketamine Hydrochloride - Agitation, Emergence | Phase 2 | Completed | Jordanian Royal Medical Services | 193 | 2022-05-11 | 2023-01-25 |
| Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets Ketamine Hydrochloride, Midazolam injection - Major Depressive Disorder, Healthy Controls | Phase 2 | Completed | University of Texas Southwestern Medical Center | 104 | 2022-05-05 | 2026-10-08 |
| A Single Ketamine Infusion Combined With Music for Suicidal Ideation Ketamine Hydrochloride, Music - Suicidal Ideation, Depressive Episode | Phase 2 | Unknown | The University of Texas Health Science Center at Tyler | 200 | 2021-07-01 | 2021-05-07 |
Showing 20 of 41. Sign in to see all of them.
Depression (11) · Depressive Disorder, Major (7) · Depressive Disorder, Treatment-Resistant (6) · Obsessive-Compulsive Disorder (6) · Suicidal Ideation (5) · Suicide (4) · Bipolar Disorder (3) · Depressive Disorder (2) · Acute Pain (1) · Alcoholism (1) · Behavior, Addictive (1) · Behavioral Symptoms (1) · Borderline Personality Disorder (1) · Bronchiolitis Obliterans Syndrome (1) · Chemsex (1)
New York State Psychiatric Institute (4) · Joshua Rosenblat (3) · Stanford University (2) · The University of Texas Health Science Center, Houston (2) · University Health Network, Toronto (2) · University of Texas Southwestern Medical Center (2) · Assiut University (1) · Beijing Tiantan Hospital (1) · Beth Israel Deaconess Medical Center (1) · Dan Iosifescu (1) · Fundació Sant Joan de Déu (1) · Gil Yosipovitch (1) · Hospital Italiano de Buenos Aires (1) · Jenna L Leclerc MD, PhD (1) · Jordanian Royal Medical Services (1)
United States (26) · Canada (8) · Argentina (1) · China (1) · Czechia (1) · Egypt (1) · Jordan (1) · Norway (1) · Spain (1)
Joshua Rosenblat, MD, MSc (2) · Alan Peterson, PhD, ABPP (1) · Ali M. Abu Dalo, MD (1) · Andreas W Blomkvist, M.D. (1) · Carlos A Zarate, M.D. (1) · Carolyn I Rodriguez, M.D., Ph.D. (1) · Carolyn I Rodriguez, MD, PhD (1) · Carolyn I. Rodriguez, M.D., Ph.D. (1) · Dan Iosifescu, MD, MSc (1) · Daniel Talmor, MD, MPH (1) · Devang K Sanghavi, M.B.B.S., M.D. (1) · Devang Sanghavi, MBBS, MD (1) · Federico Carini, M.D. (1) · Gil Yosipovitch, MD (1) · H Blair Simpson, MD, PhD (1)
PMID 21527129, PMID 23783065, PMID 26104826, PMID 27046314, PMID 30157913, PMID 30922101, PMID 32757505, PMID 33407719, PMID 34633992, PMID 34971723, PMID 35267254, PMID 35931041, PMID 37997749, PMID 38874947, PMID 40850924, PMID 41555748, PMID 42171126, PMID 42684694, PMID 42808010
2023 (1), 2KL2TR001870 (1), IK2CX002646-01A2 (1), K12DA031794 (1), K23MH092434 (1), KL2TR003168 (1), R01MH123142 (1), R01MH133553 (1), R01NS125482 (1), UL1TR002645 (1)