11 recruiting, 8 completed, 6 unknown, 3 active not recruiting. 33 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 33 | Recruiting 11, Completed 8, Unknown 6, Active not recruiting 3, Withdrawn 3, Terminated 2 |
| Phase 2 | 7 | Completed 3, Recruiting 3, Withdrawn 1 |
Follow Ketamine hydrochloride: new trials by email Literature Review of Ketamine hydrochloride trials Research Report on Ketamine hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Morphine or Ketamine for Analgesia Ketamine hydrochloride, Morphine sulphate - Abdominal Pain, Isolated Extremity Fracture | Phase 3 | Recruiting | Columbia University | 1010 | 2026-10-17 | 2026-10-20 |
| Ketamine Sedation in the ICU (KANINE) RCT ketamine hydrochloride, Normal saline placebo - Mechanical Ventilation, Critically Ill Intensive Care Unit Patients | Phase 3 | Recruiting | McMaster University | 54 | 2025-11-20 | 2026-10-22 |
| Effect of Different Anesthetic Drugs on Electrocorticography (ECOG). Fentanyl (IV), Ketamine (0.5 mg/kg) - Epilepsy, Brain Tumor | Phase 3 | Active not recruiting | Children's Cancer Hospital Egypt 57357 | 88 | 2025-08-18 | 2025-09-10 |
| Ketamine Augmentation of ECT in Treatment-Resistant Depression Ketamine Hydrochloride, Placebo - Major Depressive Disorder, Treatment Resistant Depression | Phase 3 | Recruiting | Università Vita-Salute San Raffaele | 30 | 2025-07-10 | 2026-05-11 |
| Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure Clozapine, Esketamine Nasal Product, Escitalopram - Schizophrenia and Related Disorders, Major Depressive Disorder | Phase 3 | Recruiting | Dr. Inge Winter | 1254 | 2025-04-27 | 2026-01-22 |
| Understanding and Treating Suicidal Ideation With Ketamine ketamine hydrochloride - Suicidal Ideation, Major Depressive Disorder (MDD) | Phase 2 / Phase 3 | Recruiting | The Royal's Institute of Mental Health Research | 36 | 2025-04-08 | 2026-05-19 |
| The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. Esketamine Nasal Product, Ketamine Hydrochloride, Esketamine hydrochloride - Major Depressive Disorder, Treatment Resistant Depression | Phase 3 | Recruiting | Dr. Inge Winter | 418 | 2024-08-31 | 2025-09-26 |
| Predictors of Intravenous Ketamine Response in TRD Ketamine, Midazolam - Treatment Resistant Depression, Major Depressive Disorder | Phase 3 | Active not recruiting | Abraham Nunes | 40 | 2024-01-19 | 2026-05-22 |
| Prehospital Analgesia INtervention Trial (PAIN) Ketamine Hydrochloride, Fentanyl Citrate - Traumatic Injury | Phase 3 | Recruiting | Jason Sperry | 994 | 2023-11-27 | 2026-03-09 |
| Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal Ideation Ketamine Hydrochloride, Normal saline - Suicidal Ideation | Phase 3 | Unknown | University of Ottawa | 20 | 2023-06-01 | 2023-02-13 |
| Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage Ketamine Hydrochloride, Propofol - Subarachnoid Hemorrhage, Aneurysmal | Phase 2 / Phase 3 | Withdrawn | Jenna L Leclerc MD, PhD | 2023-04-27 | 2023-05-01 | |
| Ketamine & Crisis Response Plan for Suicidal Ideation in the ED Ketamine Hydrochloride, Crisis Response Plan - Suicide | Phase 2 / Phase 3 | Recruiting | The University of Texas Health Science Center at San Antonio | 24 | 2023-01-06 | 2026-09-30 |
| Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents Ketamine Hydrochloride, Midazolam Hydrochloride - Suicide, Attempted, Suicide and Depression | Phase 3 | Completed | University of Texas Southwestern Medical Center | 50 | 2022-10-03 | 2026-10-15 |
| Ketamine Treatment of Youth Suicide Attempters Ketamine Hydrochloride, Saline, CAMS Therapy - Suicide, Attempted | Phase 3 | Recruiting | Tatiana Falcone, MD | 60 | 2022-06-27 | 2026-07-16 |
| Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches Ketamine, 0.9% Saline - Chronic Daily Headache | Phase 3 | Recruiting | University Health Network, Toronto | 56 | 2022-06-01 | 2026-06-08 |
| Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation IN Ketodex (D4K2), IN Ketodex (D3K3), IN Ketodex (D2K4) - Fracture, Dislocation | Phase 2 / Phase 3 | Recruiting | Naveen Poonai | 400 | 2020-03-11 | 2024-11-05 |
| Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery Ketamine, Placebo Ketamine, Lidocaine - Postoperative Pain Control, Opioid Consumption | Phase 3 | Terminated | Case Comprehensive Cancer Center | 30 | 2020-01-17 | 2024-11-12 |
| Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department Ketamine Hydrochloride, Normal saline - Suicide, Suicide Threat | Phase 3 | Terminated | Naval Medical Center Camp Lejeune | 1 | 2020-01-14 | 2025-05-14 |
| Endogenous Opioid Modulation by Ketamine Ketamine Hydrochloride, Normal saline - Major Depressive Disorder | Phase 3 | Withdrawn | University of Utah | 2019-08-01 | 2020-01-28 | |
| Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal Ketamine Ketamine Hydrochloride - Depressive Disorder, Treatment-Resistant | Phase 2 / Phase 3 | Completed | Dan Iosifescu | 9 | 2019-06-26 | 2021-01-22 |
Showing 20 of 33. Sign in to see all of them.
Depression (7) · Depressive Disorder, Major (6) · Suicidal Ideation (6) · Depressive Disorder, Treatment-Resistant (5) · Fractures, Bone (4) · Suicide (4) · Bipolar Disorder (3) · Emergencies (3) · Pain (3) · Anxiety Disorders (2) · Joint Dislocations (2) · Shock, Septic (2) · Suicide, Attempted (2) · Abdominal Pain (1) · Agnosia (1)
Cairo University (2) · Dr. Inge Winter (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · University of Ottawa (2) · Abraham Nunes (1) · Assistance Publique - Hôpitaux de Paris (1) · Augusta University (1) · Beijing Tiantan Hospital (1) · Case Comprehensive Cancer Center (1) · Children's Cancer Hospital Egypt 57357 (1) · Columbia University (1) · Dan Iosifescu (1) · Fondation Lenval (1) · Jason McMullan (1) · Jason Sperry (1)
United States (12) · Canada (8) · Egypt (3) · France (2) · Italy (2) · United Kingdom (2) · Austria (1) · China (1) · Germany (1) · Greece (1) · Israel (1) · Spain (1)
Naveen Poonai, MD (3) · Abraham Nunes, MD PhD MBA FRCPC (1) · Ahmed Hasanin, Professor (1) · Alan Peterson, PhD, ABPP (1) · Alberto AZ Zangrillo, MD (1) · Amy L Drendel, DO, MS (1) · Anuj Bhatia, MD, PhD (1) · Ashraf Rady, Professor (1) · Barry J.A. Laird, MD (1) · Cristina CC Colombo, MD (1) · Dan Iosifescu, MD, MSc (1) · Daniel S Tsze, MD, MPH (1) · Dawn Ionescu, M.D. (1) · Franck Verdonk, MD, PhD (1)
PMID 28025837, PMID 29923953, PMID 30157913, PMID 30922101, PMID 31082965, PMID 32300671, PMID 32898698, PMID 33407719, PMID 34633992, PMID 34971723, PMID 35141873, PMID 35931041, PMID 36855160, PMID 38710325, PMID 38767196, PMID 38969374, PMID 39428602, PMID 39672260, PMID 41401709, PMID 42849709
2016 (1), 2023 (1), R01MH125181 (1), R01MH125214 (1), U01HD116253 (1), UL1TR002645 (1)