55 completed, 23 unknown, 22 recruiting, 12 terminated. 41 Phase 2, 33 Phase 3, 22 Phase 4, 16 Not applicable, 15 Phase 1.
Follow Ketamine hydrochloride: new trials by email Literature Review of Ketamine hydrochloride trials Research Report on Ketamine hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Morphine or Ketamine for Analgesia Ketamine hydrochloride, Morphine sulphate - Abdominal Pain, Isolated Extremity Fracture | Phase 3 | Recruiting | Columbia University | 1010 | 2026-10-17 | 2026-10-20 |
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) - Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder | Phase 2 | Recruiting | Joshua Rosenblat | 120 | 2026-07-16 | 2026-07-29 |
| Ketamine in Severe Traumatic Brain Injury Ketamine Hydrochloride - Traumatic Brain Injury, Traumatic Encephalopathy | Early Phase 1 | Withdrawn | University of Texas Southwestern Medical Center | 2026-06-01 | 2026-10-07 | |
| Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients Ketamine (0.5 mg/kg), Normal Saline (0.9% NaCl) - Critical Illness, Depressive Symptoms | Phase 2 | Recruiting | Hospital Italiano de Buenos Aires | 50 | 2026-05-14 | 2026-09-02 |
| Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression Ketamine hydrochloride, Minimally Enhanced Usual Care, Brief narrative intervention - Chronic Low Back Pain, Depression | Phase 2 | Recruiting | VA Office of Research and Development | 44 | 2025-12-03 | 2025-12-18 |
| Ketamine Sedation in the ICU (KANINE) RCT ketamine hydrochloride, Normal saline placebo - Mechanical Ventilation, Critically Ill Intensive Care Unit Patients | Phase 3 | Recruiting | McMaster University | 54 | 2025-11-20 | 2026-10-22 |
| Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surgery ketamine, Nalbuphine, Dexmedetomidine - Orofacial Clefts, Cleft Lip and Palate | Not applicable | Recruiting | University Medical Centre Ljubljana | 60 | 2025-09-01 | 2026-01-14 |
| Effect of Different Anesthetic Drugs on Electrocorticography (ECOG). Fentanyl (IV), Ketamine (0.5 mg/kg) - Epilepsy, Brain Tumor | Phase 3 | Active not recruiting | Children's Cancer Hospital Egypt 57357 | 88 | 2025-08-18 | 2025-09-10 |
| Ketamine Augmentation of ECT in Treatment-Resistant Depression Ketamine Hydrochloride, Placebo - Major Depressive Disorder, Treatment Resistant Depression | Phase 3 | Recruiting | Università Vita-Salute San Raffaele | 30 | 2025-07-10 | 2026-05-11 |
| A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients Ketamine Hydrochloride, Placebo - Depression | Phase 2 | Terminated | Mayo Clinic | 1 | 2025-07-07 | 2026-08-12 |
| Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure Clozapine, Esketamine Nasal Product, Escitalopram - Schizophrenia and Related Disorders, Major Depressive Disorder | Phase 3 | Recruiting | Dr. Inge Winter | 1254 | 2025-04-27 | 2026-01-22 |
| Understanding and Treating Suicidal Ideation With Ketamine ketamine hydrochloride - Suicidal Ideation, Major Depressive Disorder (MDD) | Phase 2 / Phase 3 | Recruiting | The Royal's Institute of Mental Health Research | 36 | 2025-04-08 | 2026-05-19 |
| Ketamine-Assisted Recovery for Methamphetamine Use Disorder & HIV Ketamine, Psychotherapy - Methamphetamine Use Disorder | Phase 2 | Completed | Nicky Mehtani, MD, MPH | 17 | 2025-03-04 | 2026-08-12 |
| Ketamine for Combined Depression and Alcohol Use Disorder Ketamine Hydrochloride, Midazolam Hydrochloride - Depression, Alcohol Use Disorder | Phase 1 / Phase 2 | Recruiting | University Hospital of North Norway | 34 | 2025-01-20 | 2026-06-23 |
| Ketamine for Methamphetamine Use Disorder Ketamine Hydrochloride, Midazolam Hydrochloride - Substance Use Disorders, Substance Use | Phase 2 | Completed | University of Texas Southwestern Medical Center | 120 | 2024-09-11 | 2026-10-27 |
| Imaging Depression in Parkinson's Disease 11C-UCB-J, ketamine hydrochloride - Parkinson's Disease, Major Depressive Disorder | Phase 2 | Recruiting | Yale University | 120 | 2024-09-01 | 2026-03-10 |
| The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. Esketamine Nasal Product, Ketamine Hydrochloride, Esketamine hydrochloride - Major Depressive Disorder, Treatment Resistant Depression | Phase 3 | Recruiting | Dr. Inge Winter | 418 | 2024-08-31 | 2025-09-26 |
| Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2) Ketamine, Naltrexone Pill, Placebo pill - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Stanford University | 150 | 2024-02-24 | 2026-04-24 |
| Predictors of Intravenous Ketamine Response in TRD Ketamine, Midazolam - Treatment Resistant Depression, Major Depressive Disorder | Phase 3 | Active not recruiting | Abraham Nunes | 40 | 2024-01-19 | 2026-05-22 |
| Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal Ideation Ketamine Hydrochloride, Normal saline - Suicidal Ideation, Suicidal Ideas | Not applicable | Unknown | Children's Hospital of Eastern Ontario | 20 | 2024-01-15 | 2024-06-05 |
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Depression (24) · Depressive Disorder, Major (22) · Depressive Disorder, Treatment-Resistant (12) · Suicidal Ideation (10) · Bipolar Disorder (9) · Obsessive-Compulsive Disorder (8) · Pain (7) · Suicide (7) · Agnosia (5) · Anxiety Disorders (5) · Depressive Disorder (5) · Pain, Postoperative (5) · Stress Disorders, Post-Traumatic (5) · Chronic Pain (4) · Fractures, Bone (4)
New York State Psychiatric Institute (6) · University of Texas Southwestern Medical Center (5) · Stanford University (4) · Cairo University (3) · Joshua Rosenblat (3) · Massachusetts General Hospital (3) · University Health Network, Toronto (3) · Assiut University (2) · Dr. Inge Winter (2) · Kasr El Aini Hospital (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Mayo Clinic (2) · Medical University of South Carolina (2) · The University of Texas Health Science Center, Houston (2) · University of Ottawa (2)
United States (56) · Canada (21) · Egypt (9) · China (4) · United Kingdom (4) · Austria (2) · France (2) · Israel (2) · Italy (2) · Spain (2) · Turkey (Türkiye) (2) · Argentina (1) · Brazil (1) · Colombia (1) · Czechia (1)
Naveen Poonai, MD (3) · Dawn Ionescu, M.D. (2) · Joshua Rosenblat, MD, MSc (2) · Madhukar Trivedi, MD (2) · Abraham Nunes, MD PhD MBA FRCPC (1) · Ahmed Hasanin, Professor (1) · Alan Peterson, PhD, ABPP (1) · Alberto AZ Zangrillo, MD (1) · Ali M. Abu Dalo, MD (1) · Amy L Drendel, DO, MS (1) · Andreas W Blomkvist, M.D. (1) · Anna Bashmakov, D.O. (1) · Annabelle Belcher, PhD (1) · Anshi Wu Wu, Ph.D (1)
PMID 39428602, PMID 10966311, PMID 12873568, PMID 16703233, PMID 17338847, PMID 18274461, PMID 18790440, PMID 21263301, PMID 21527129, PMID 21563653, PMID 23403253, PMID 23783065, PMID 24131410, PMID 25448584, PMID 25478364, PMID 25535501, PMID 26104826, PMID 26871805, PMID 27046314, PMID 27219513, PMID 27829367, PMID 27871770, PMID 28025837, PMID 29167877, PMID 29923953, PMID 30157913, PMID 30724832, PMID 30922101, PMID 30999057, PMID 31082965, PMID 32300671, PMID 32757505, PMID 32898698, PMID 33031861, PMID 33084081, PMID 33407719, PMID 34034067, PMID 34193480, PMID 34633992, PMID 34971723, PMID 35141873, PMID 35267254, PMID 35448950, PMID 35931041, PMID 36419181, PMID 36570810, PMID 36855160, PMID 36889160, PMID 37194253, PMID 37997749
2023 (2), 2016 (1), 2KL2TR001870 (1), IK2CX002646-01A2 (1), K12DA031794 (1), K23MH092434 (1), K23MH107776 (1), KL2TR003168 (1), R01MH123142 (1), R01MH125181 (1), R01MH125214 (1), R01MH133553 (1), R01NS125482 (1), U01HD116253 (1), UL1TR002645 (1)